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Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > N-(3-BROMOPHENYL)-6,7-DIMETHOXYQUINAZOLIN-4-AMINE
N-(3-BROMOPHENYL)-6,7-DIMETHOXYQUINAZOLIN-4-AMINE structure, CAS 153436-54-5

N-(3-BROMOPHENYL)-6,7-DIMETHOXYQUINAZOLIN-4-AMINE

CAS Number153436-54-5

SynonymsN-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine; PD-153035; N-(3-Bromophenyl)-6,7-dimethoxy-4-quinazolinamine; PD153035

Molecular FormulaC16H14BrN3O2

Molecular Weight360.21

Purity≥97 (HPLC)%

Density1.5±0.1 g/cm3

Boiling Point472.1±45.0 °C at 760 mmHg

Melting Point

Flash Point

Appearancesolid

EINECS0

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-0160944 Purity: ≥97 (HPLC)%
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Quality Control of [ 153436-54-5 ] Purity: ≥97 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number153436-54-5
Catalog No.2A-0160944
Chinese Name4-[(3-溴苯基)氨基]-6,7-二甲氧基喹啉
SynonymsN-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine; PD-153035; N-(3-Bromophenyl)-6,7-dimethoxy-4-quinazolinamine; PD153035
Molecular FormulaC16H14BrN3O2
Molecular Weight360.21
Purity≥97 (HPLC)
Density1.5±0.1 g/cm3
Boiling Point472.1±45.0 °C at 760 mmHg
Appearancesolid
Storage Condition2-8°C
ApplicationPD153035 (ZM 252868; AG 1517; Tyrphostin AG 1517; SU 5271) is a potent EGFR inhibitor with Ki and IC50 values ​​of 6 and 25 pM, respectively.
EINECS0
HTC2933990090
UN(IATA)0
PubChem ID7799416
MDL NumberMFCD00934896
SMILESBrc1cc(ccc1)Nc2ncnc3c2cc(c(c3)OC)OC
InChI1S/C16H14BrN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
InChI KeyLSPANGZZENHZNJ-UHFFFAOYSA-N
NACRES CodeNA.77
UNSPSC12352200
MSDSmsds/160944_1_153436_54_5.pdf
Use ofPD153035 (ZM 252868;AG 1517;Tyrphostin AG 1517;SU 5271) is a potent EGFR inhibitor with Ki and IC50 of 6 and 25 pM, respectively. Properties Name N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine Synonym More Synonyms PD153035 Biological Activity Description PD153035 (ZM 252868;AG 1517;Tyrphostin AG 1517;SU 5271) is a potent EGFR inhibitor with Ki and IC50 of 6 and 25 pM, respectively. Related Catalog Research Areas >> Cancer EGFR:6 pM (Ki) EGFR:25 pM (IC50) Cell Assay Different EGF receptor-overexpressing cell lines (A43 1, Difi, MDA-MB-468, MDA-MB-231, DU145, SiHa, C4i, and MEl 80) are treated with PD153035 at increasing concentrations of 0.125-2.5 p.M. Growth inhibitory effect in monolayer cell culture is assessed[3]. References [2]. Fry DW, et al. A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science. 1994 Aug 19;265(5175):1093-5. [3]. Bos M, et al. PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptoractivation and inhibits growth of cancer cells in a receptor number-dependent manner. Clin Cancer Res. 1997 Nov;3(11):2099-106. [4]. Kunkel MW, et al. Inhibition of the epidermal growth factor receptor tyrosine kinase by PD153035 in human A431 tumors in athymic nude mice. Invest New Drugs. 1996;13(4):295-302. Chemical & Physical Properties Molecular Formula C16H14BrN3O2 Exact Mass 359.026947 PSA 56.27000 Index of Refraction 1.679 InChIKey LSPANGZZENHZNJ-UHFFFAOYSA-N Safety Information Hazard Codes Xi HS Code 2933990090 Synthetic Route 3-Bromoaniline CAS#:591-19-5 4-Chloro-6,7-di... CAS#:13790-39-1 CAS#:153436-54-5 Literature: Marzaro, Giovanni; Guiotto, Adriano; Pastorini, Giovanni; Chilin, Adriana Tetrahedron, 2010 , vol. 66, # 4 p. 962 - 968 N'-(2-cyano-4,5... CAS#:385784-68-9 3-Bromoaniline CAS#:591-19-5 CAS#:153436-54-5 Literature: Wang, Zheng; Wang, Cuiling; Sun, Yanni; Zhang, Ning; Liu, Zhulan; Liu, Jianli Tetrahedron, 2014 , vol. 70, # 4 p. 906 - 913 2-Amino-4,5-dim... CAS#:5653-40-7 CAS#:153436-54-5 Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 41, # 7 p. 623 - 629 Precursor & DownStream Precursor 8 CAS#:591-19-5 3-Bromoaniline CAS#:13790-39-1 4-Chloro-6,7-di... CAS#:385784-68-9 N'-(2-cyano-4,5... CAS#:5653-40-7 2-Amino-4,5-dim... DownStream 1 CAS#:169205-86-1 4-((3-BROMOPHEN...
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SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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