| Chemical & Physical Properties | |
|---|---|
| CAS Number | 101526-83-4 |
| Catalog No. | 2A-0160546 |
| Chinese Name | 司美利特盐酸盐 |
| Synonyms | C14H23N3O3S; UNII-0NHB13IN3R; Sematilide |
| Molecular Formula | C13H23N3O5S |
| Molecular Weight | 333.409 |
| Purity | 96+ |
| Density | 1.205 g/cm3 |
| Melting Point | 141-142 °C |
| Appearance | solid |
| Storage Condition | 2-8°C, sealed, dry |
| Application | Sematilide (CK-1752) is a selective IKr channel blocker. Sematilide inhibits delayed rectifier potassium channels (K+ current) with an IC50 of 25 μM in a concentration-dependent manner. Sematilide is |
| EINECS | 0 |
| HTC | 2935009090 |
| UN(IATA) | 0 |
| PubChem ID | 14850171 |
| MDL Number | MFCD00025363 |
| SMILES | CCN(CC)CCNC(=O)c1ccc(NS(C)(=O)=O)cc1 |
| InChI | InChI=1S/C14H23N3O3S/c1-4-17(5-2)11-10-15-14(18)12-6-8-13(9-7-12)16-21(3,19)20/h6-9,16H,4-5,10-11H2,1-3H3,(H,15,18) |
| InChI Key | KHYPYQZQJSBPIX-UHFFFAOYSA-N |
| MSDS | msds/160546_1_101526_83_4.pdf |
| Use of | Sematilide (CK-1752) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM). Sematilide is a class III antiarrhythmic agent[1]. Properties Name N-[2-(diethylamino)ethyl]-4-(methanesulfonamido)benzamide Synonym More Synonyms Sematilide Biological Activity Description Sematilide (CK-1752) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM). Sematilide is a class III antiarrhythmic agent[1]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel IC50: 25 μM (K+ current)[1] In Vitro Application of 10, 30, 100 and 300 μM Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM)[1]. References [1]. Ishii Y, et al. Effects of Sematilide, a novel class III antiarrhythmic agent, on membrane currents in rabbit atrial myocytes. Eur J Pharmacol. 1997 Jul 23;331(2-3):295-302. [2]. Stanley S. Greenberg, et al. Pharmacology of Sematilide, a non-quaternary class III antiarrhythmic agent. Chemical & Physical Properties Molecular Formula C14H23N3O3S Exact Mass 313.14600 PSA 86.89000 LogP 2.67440 Index of Refraction 1.558 InChIKey KHYPYQZQJSBPIX-UHFFFAOYSA-N Safety Information HS Code 2935009090 Synthetic Route Total: 1 Page 4-methylsulphon... CAS#:50790-28-8 2-aminoethyldie... CAS#:100-36-7 Sematilide CAS#:101526-83-4 Literature: Lumma, William C.; Wohl, Ronald A.; Davey, David D.; Argentieri, Thomas M.; DeVita, Robert J.; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 755 - 758 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Product name: Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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