CAS Number45120-30-7
SynonymsL-Glutamic acid, 1-(1,1-dimethylethyl) ester; L-Glutamic acid α-tert·butyl ester; (4S)-4-Amino-5-[(2-methyl-2-propanyl)oxy]-5-oxopentanoic acid; (4S)-4-Amino-5-tert-butoxy-5-oxopentanoic acid (non-preferred name); H-Glu-OtBu
Molecular FormulaC9H17NO4
Molecular Weight203.24
Purity96+%
Density1.1±0.1 g/cm3
Boiling Point326.8±32.0 °C at 760 mmHg
Melting Point140ºC
AppearancePowder | White
EINECS0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 45120-30-7 |
| Catalog No. | 2A-0156073 |
| Chinese Name | l-谷氨酸1-叔丁酯 |
| Synonyms | L-Glutamic acid, 1-(1,1-dimethylethyl) ester; L-Glutamic acid α-tert·butyl ester; (4S)-4-Amino-5-[(2-methyl-2-propanyl)oxy]-5-oxopentanoic acid; (4S)-4-Amino-5-tert-butoxy-5-oxopentanoic acid (non-preferred name); H-Glu-OtBu |
| Molecular Formula | C9H17NO4 |
| Molecular Weight | 203.24 |
| Purity | 96+ |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 326.8±32.0 °C at 760 mmHg |
| Melting Point | 140ºC |
| Appearance | Powder | White |
| Water Solubility | Water solubility: soluble |
| Storage Condition | Sealed, cool and dry storage |
| Application | H-Glu-OtBu is a non-cleavable ADC linker for the synthesis of antibody drug conjugates (ADC). H-Glu-OtBu is also a PROTAC linker based on alkyl chains and can be used to synthesize PROTAC[1][2] |
| EINECS | 0 |
| HTC | 2922509090 |
| UN(IATA) | 0 |
| PubChem ID | 10237579 |
| SMILES | CC(C)(C)OC(=O)C(N)CCC(=O)O |
| InChI | InChI=1S/C9H17NO4/c1-9(2,3)14-8(13)6(10)4-5-7(11)12/h6H,4-5,10H2,1-3H3,(H,11,12)/t6-/m0/s1 |
| InChI Key | QVAQMUAKTNUNLN-LURJTMIESA-N |
| Use of | H-Glu-OtBu is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Glu-OtBu is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2 Properties Name (S)-4-Amino-5-(tert-butoxy)-5-oxopentanoic acid Synonym More Synonyms H-Glu-OtBu Biological Activity Description H-Glu-OtBu is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Glu-OtBu is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2 Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Molecular Formula C9H17NO4 Exact Mass 203.115753 PSA 89.62000 Appearance of Characters Powder | White Index of Refraction 1.476 InChIKey QVAQMUAKTNUNLN-LURJTMIESA-N SMILES CC(C)(C)OC(=O)C(N)CCC(=O)O Safety Information Hazard Codes Xi HS Code 2922509090 Synthetic Route Z-Glu-OtBu CAS#:5891-45-2 H-Glu-OtBu CAS#:45120-30-7 Literature: Eli Lilly and Company; COR Therapeutics Inc. Patent: US6291469 B1, 2001 ; Fmoc-Glu-OtBu CAS#:84793-07-7 H-Glu-OtBu CAS#:45120-30-7 L-Glutamic acid... CAS#:80165-23-7 H-Glu-OtBu CAS#:45120-30-7 Literature: Roeske,R. Journal of Organic Chemistry, 1963 , vol. 28, p. 1251 - 1253 Precursor & DownStream Precursor 6 CAS#:5891-45-2 Z-Glu-OtBu CAS#:84793-07-7 Fmoc-Glu-OtBu CAS#:80165-23-7 L-Glutamic acid... CAS#:1676-73-9 H-Glu(OBzl)-OH DownStream 2 CAS#:84793-07-7 Fmoc-Glu-OtBu CAS#:73610-81-8 L-Glutamic acid... |
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