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FMOC-LYS-OH.HCL structure, CAS 139262-23-0

FMOC-LYS-OH.HCL

CAS Number139262-23-0

SynonymsNalpha-Fmoc-L-lysinehydrochloride; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-aminohexanoic acid hydrochloride; Fmoc-Lys-OH hydrochloride; Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-lysine Hydrochloride; Fmoc-Lys-OH.HCl; Fmoc-L-lysine HCl; N2-Fmoc-L-lysine HCl; MFCD00190889; Fmoc-L-lysine hydrochloride; Nalpha-Fmoc-L-Lysine Hydrochloride; L-Lysine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, hydrochloride (1:1); Nalpha-[(9H-Fluoren-9-ylMethoxy)carbonyl]-L-lysine Hydrochloride; Fmoc-Lys-OH inverted exclamation mark currencyHCl; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-lysine hydrochloride (1:1); Nα-Fmoc-L-lysine Hydrochloride

Molecular FormulaC21H25ClN2O4

Molecular Weight404.89

Purity96+%

Density

Boiling Point607.6ºC at 760 mmHg

Melting Point

Flash Point

AppearanceSolid;White to Almost white powder to crystal

EINECS0

MSDSChineseEnglish

Symboltransportation

Signal WordWarning

Cat. No.: 2A-0155813 Purity: 96+%
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Quality Control of [ 139262-23-0 ] Purity: 96+% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number139262-23-0
Catalog No.2A-0155813
Chinese NameFmoc-L-赖氨酸盐酸盐
SynonymsNalpha-Fmoc-L-lysinehydrochloride; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-aminohexanoic acid hydrochloride; Fmoc-Lys-OH hydrochloride; Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-lysine Hydrochloride; Fmoc-Lys-OH.HCl; Fmoc-L-lysine HCl; N2-Fmoc-L-lysine HCl; MFCD00190889; Fmoc-L-lysine hydrochloride; Nalpha-Fmoc-L-Lysine Hydrochloride; L-Lysine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, hydrochloride (1:1); Nalpha-[(9H-Fluoren-9-ylMethoxy)carbonyl]-L-lysine Hydrochloride; Fmoc-Lys-OH inverted exclamation mark currencyHCl; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-lysine hydrochloride (1:1); Nα-Fmoc-L-lysine Hydrochloride
Molecular FormulaC21H25ClN2O4
Molecular Weight404.89
Purity96+
Boiling Point607.6ºC at 760 mmHg
AppearanceSolid;White to Almost white powder to crystal
Water SolubilitySoluble in: methanol
Storage Condition2-8°C
ApplicationFmoc-Lys-OH hydrochloride is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADC). Fmoc Lys OH hydrochloride is also a PROTAC linker based on alkyl chains and can be used to synt
EINECS0
HTC2924299090
UN(IATA)0
PubChem ID57647629
MDL NumberMFCD00190889
SMILESCl.NCCCCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
InChIInChI=1S/C21H24N2O4.ClH/c22-12-6-5-11-19(20(24)25)23-21(26)27-13-18-16-9-3-1-7-14(16)15-8-2-4-10-17(15)18;/h1-4,7-10,18-19H,5-6,11-13,22H2,(H,23,26)(H,24,25);1H/t19-;/m0./s1
InChI KeyMVMZFAIUUXYFGY-FYZYNONXSA-N
Beilstein/REAXYS8663370
NACRES CodeNA.26
UNSPSC12352202
Hazard Symbolstransportation
BioactivityFmoc-Lys-OH hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys-OH hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Target Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Boiling Point 607.6ºC at 760 mmHg Molecular Formula C21H25ClN2O4 Molecular Weight 404.887 Flash Point 321.3ºC Exact Mass 404.150299 PSA 101.65000 LogP 5.00050 Vapour Pressure 1.29E-15mmHg at 25°C Index of Refraction -11.0 ° (C=1, DMF) InChIKey MVMZFAIUUXYFGY-FYZYNONXSA-N SMILES Cl.NCCCCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O Storage condition 2-8°C
Use ofFmoc-Lys-OH hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys-OH hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. Properties Name (2S)-6-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid,hydrochloride Synonym More Synonyms Fmoc-Lys-OH hydrochloride Biological Activity Description Fmoc-Lys-OH hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys-OH hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Exact Mass 404.150299 PSA 101.65000 LogP 5.00050 InChIKey MVMZFAIUUXYFGY-FYZYNONXSA-N
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SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 30.0%
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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