CAS Number35665-38-4
SynonymsN-9-fluorenylmethoxycarbonyl-glycyl-glycine; Fmoc-Gly-Gly; 2-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)acetamido)acetic acid; Fmoc-Gly-Gly-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycylglycine; FMOC-GLYCYL-GLYCINE
Molecular FormulaC19H18N2O5
Molecular Weight354.36
Purity96+%
Density1.3±0.1 g/cm3
Boiling Point684.1±45.0 °C at 760 mmHg
Melting Point182 °C
AppearancePowder | White
EINECS0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 35665-38-4 |
| Catalog No. | 2A-0155758 |
| Chinese Name | N-Fmoc-甘氨酰甘氨酸 |
| Synonyms | N-9-fluorenylmethoxycarbonyl-glycyl-glycine; Fmoc-Gly-Gly; 2-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)acetamido)acetic acid; Fmoc-Gly-Gly-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycylglycine; FMOC-GLYCYL-GLYCINE |
| Molecular Formula | C19H18N2O5 |
| Molecular Weight | 354.36 |
| Purity | 96+ |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 684.1±45.0 °C at 760 mmHg |
| Melting Point | 182 °C |
| Appearance | Powder | White |
| Storage Condition | -15°C |
| Application | Fmoc-Gly-Gly-OH is a cleavable ADC linker that can be used to synthesize antibody drug conjugates (ADCs). |
| EINECS | 0 |
| HTC | 2924299090 |
| UN(IATA) | 0 |
| PubChem ID | 43615568 |
| MDL Number | MFCD00190880 |
| SMILES | O=C(O)CNC(=O)CNC(=O)OCC1c2ccccc2-c2ccccc21 |
| InChI | InChI=1S/C19H18N2O5/c22-17(20-10-18(23)24)9-21-19(25)26-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2,(H,20,22)(H,21,25)(H,23,24) |
| InChI Key | FBKUOPULLUJMOC-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352106 |
| Use of | Fmoc-Gly-Gly-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Properties Name 2-[[2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]acetic acid Synonym More Synonyms Fmoc-Gly-Gly-OH Biological Activity Description Fmoc-Gly-Gly-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. Chemical & Physical Properties Molecular Formula C19H18N2O5 Exact Mass 354.121582 PSA 104.73000 Appearance of Characters Powder | White Index of Refraction 1.613 InChIKey FBKUOPULLUJMOC-UHFFFAOYSA-N Safety Information HS Code 2924299090 Synthetic Route H-Gly-Gly-OH CAS#:556-50-3 9-Fluorenylmeth... CAS#:28920-43-6 Fmoc-Gly-Gly-OH CAS#:35665-38-4 Literature: Kupihar, Zoltan; Schmel, Zoltan; Kele, Zoltan; Penke, Botond; Kovacs, Lajos Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 5 p. 1241 - 1247 H-Gly-Gly-OH CAS#:556-50-3 N-Fmoc-1H-benzo... CAS#:1131148-55-4 Fmoc-Gly-Gly-OH CAS#:35665-38-4 Literature: Ibrahim, Tarek S.; Tala, Srinivasa R.; El-Feky, Said A.; Abdel-Samii, Zakaria K.; Katritzky, Alan R. Synlett, 2011 , # 14 art. no. S03511ST, p. 2013 - 2016 Fmoc-Gly-OH CAS#:29022-11-5 Fmoc-Gly-Gly-OH CAS#:35665-38-4 Literature: Journal of the American Chemical Society, , vol. 125, # 45 p. 13680 - 13681 Precursor & DownStream Precursor 7 CAS#:556-50-3 H-Gly-Gly-OH CAS#:28920-43-6 9-Fluorenylmeth... CAS#:1131148-55-4 N-Fmoc-1H-benzo... CAS#:29022-11-5 Fmoc-Gly-OH DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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| FMOC-HYP-OBZL | 439290-35-4 | 2A-0155773 |
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