EN
0
Home > Products > Pharmaceutical R&D Materials > Heterocyclic Building Blocks > ETHYL AZETIDINE-3-CARBOXYLATE HYDROCHLORIDE
ETHYL AZETIDINE-3-CARBOXYLATE HYDROCHLORIDE structure, CAS 405090-31-5

ETHYL AZETIDINE-3-CARBOXYLATE HYDROCHLORIDE

CAS Number405090-31-5

SynonymsEthyl 3-azetidinecarboxylate hydrochloride (1:1); ethyl azetidine-3-carboxylate,hydrochloride; 3-Azetidinecarboxylic acid, ethyl ester, hydrochloride (1:1)

Molecular FormulaC6H12ClNO2

Molecular Weight165.62

Purity96+%

Density

Boiling Point

Melting Point

Flash Point

Appearancewhite solid

EINECS0

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-0155430 Purity: 96+%
Change View

Please Login or Create an Account to: See VlP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

Inquiry

Quality Control of [ 405090-31-5 ] Purity: 96+% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number405090-31-5
Catalog No.2A-0155430
Chinese Name氮杂环丁烷-3-甲酸乙酯盐酸盐
SynonymsEthyl 3-azetidinecarboxylate hydrochloride (1:1); ethyl azetidine-3-carboxylate,hydrochloride; 3-Azetidinecarboxylic acid, ethyl ester, hydrochloride (1:1)
Molecular FormulaC6H12ClNO2
Molecular Weight165.62
Purity96+
Appearancewhite solid
Storage Condition2-8°C
ApplicationAzetidine-3-carboxylic acid ethyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADC). Nitrogen mustard-3-carboxylic acid ethyl ester hydrochlorid
EINECS0
HTC2933990090
UN(IATA)0
PubChem ID90343812
SMILESCCOC(=O)C1CNC1.Cl
InChIInChI=1S/C6H11NO2.ClH/c1-2-9-6(8)5-3-7-4-5;/h5,7H,2-4H2,1H3;1H
InChI KeyRZQFZRLGHCCPGG-UHFFFAOYSA-N
BioactivityEthyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Ethyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2] Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Target Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Molecular Formula C6H12ClNO2 Molecular Weight 165.618 Exact Mass 165.055649 PSA 38.33000 LogP 0.89970 InChIKey RZQFZRLGHCCPGG-UHFFFAOYSA-N SMILES CCOC(=O)C1CNC1.Cl Storage condition 2-8°C
Use ofEthyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Ethyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2] Properties Name Ethyl azetidine-3-carboxylate hydrochloride Synonym More Synonyms Biological Activity Description Ethyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Ethyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2] Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Exact Mass 165.055649 PSA 38.33000 LogP 0.89970 InChIKey RZQFZRLGHCCPGG-UHFFFAOYSA-N
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Related Products in Heterocyclic Building Blocks
ETHYL 8-CHLORO-4-HYDROXYQUINOLINE-3-CARBOXYLATE73987-37-82A-0155398
ETHYL 8-FLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLATE63010-69-52A-0155406
ETHYL 8-METHOXYQUINOLINE-3-CARBOXYLATE71083-22-22A-0155413
ETHYL 8-OXO-5,8-DIHYDRO-[1,3]DIOXOLO[4,5-G]QUINOLINE-7-CARBOXYLATE16171-98-52A-0155418
ETHYL AZETIDINE-2-CARBOXYLATE766483-76-52A-0155428
ETHYL BENZO[D]OXAZOLE-2-CARBOXYLATE27383-87-52A-0155432
ETHYL BENZO[D]THIAZOLE-5-CARBOXYLATE103261-70-72A-0155433
ETHYL BENZO[D]THIAZOLE-7-CARBOXYLATE677304-90-42A-0155435
ETHYL FURO[2,3-C]PYRIDINE-5-CARBOXYLATE223389-14-82A-0155447
ETHYL FURO[3,2-B]PYRIDINE-5-CARBOXYLATE182691-69-62A-0155448
Browse all Heterocyclic Building Blocks products »
Contact Us

Phone:

630-322-8886

630-322-8887

Email:

[email protected]

Office Locations:

Chicago, IL, USA

San Francisco, CA, USA