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Picolinic acid structure, CAS 98-98-6

Picolinic acid

CAS Number98-98-6

Synonyms2-pyridinecarboxylic acid; Picolinic acid; pyridine-2-carboxylic acid; acidepicolique; EINECS 202-719-7; 2-Carboxypyridine; MFCD00006293; 2-acid pyridine; 2-Picolinic acid; PCL 016

Molecular FormulaC6H5NO2

Molecular Weight123.11

Purity99%

Density1.3±0.1 g/cm3

Boiling Point292.5±13.0 °C at 760 mmHg

Melting Point139-142 °C (lit.)

Flash Point

Appearancecrystals

EINECS202-719-7

MSDSChineseEnglish

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Cat. No.: 2A-9015317 Purity: 99%
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Quality Control of [ 98-98-6 ] Purity: 99% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number98-98-6
Catalog No.2A-9015317
Chinese Name2-吡啶甲酸
Synonyms2-pyridinecarboxylic acid; Picolinic acid; pyridine-2-carboxylic acid; acidepicolique; EINECS 202-719-7; 2-Carboxypyridine; MFCD00006293; 2-acid pyridine; 2-Picolinic acid; PCL 016
Molecular FormulaC6H5NO2
Molecular Weight123.11
Purity99
Density1.3±0.1 g/cm3
Boiling Point292.5±13.0 °C at 760 mmHg
Melting Point139-142 °C (lit.)
Appearancecrystals
Water Solubility887 g/L (20 ºC)
Storage ConditionStore in a cool, ventilated warehouse. Keep away f
ApplicationPCL 016 is a topical antiviral drug found to inhibit adenovirus replication in rabbits.
EINECS202-719-7
HTC29333999
PubChem ID24898523
MDL NumberMFCD00006293
SMILESOC(=O)c1ccccn1
InChI1S/C6H5NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H,(H,8,9)
InChI KeySIOXPEMLGUPBBT-UHFFFAOYSA-N
Beilstein/REAXYS109595
NACRES CodeNA.22
UNSPSC12352100
Hazard SymbolsTransport
MSDSmsds/15317_1_98_98_6.pdf
BioactivityPCL 016 is a topical antiviral agent, which inhibits adenovirus replication in rabbit. Related Catalog Natural Products >> Others Research Areas >> Infection Target Human Endogenous Metabolite In Vivo Topical 1.5% PCL, 0.8% PCL, 0.369% PCL (pH7), 0.369% PCL (pH4) and 0.5% CDV are significantly more effective than the Control in reducing Ad Positive Cultures/Total (Days 1-14) and the Duration of Ad Shedding in the Ad5/NZW rabbit ocular model. Although not statistically significant, there appears to be a trend toward concentration-dependent efficacy of PCL 016 on the Duration of Ad Shedding. There is no apparent ocular toxicity associated with PCL 016 concentrations[1]. Animal Admin Rabbits[1] 25 NZW rabbits are topically inoculated in both eyes, following corneal scarification, with 1.5 x 106 pfu/eye of Ad5. On day 1, the rabbits are divided into 6 topical treatment groups: I - 1.5% PCL 016 pH 7.0 (n=4); II - 0.8% PCL 016 pH 7.0 (n=4); III - 0.369% PCL 016 pH 7.0 (n=4); IV - 0.369% PCL 016 pH 4.0 (n=4); V - 0.5% Cidofovir (CDV) (n=4); VI - Control (saline) (n=5). PCL 016 and control rabbits are treated in both eyes 4 times daily for 7 days, while CDV rabbits are treated in both eyes twice daily for 7 days. All eyes are cultured for virus on days 0, 1, 3, 4, 5, 7, 9, 11, and 14[1]. References [1]. E.G. Romanowski, et al. A Novel Topical Antiviral Agent, PCL-016 (Picolinic Acid), Inhibits Adenovirus Replication in the Ad5/NZW Rabbit Ocular Model. ARVO Annual Meeting Abstract. May 2005 Volume 46, Issue 13. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 292.5±13.0 °C at 760 mmHg Melting Point 139-142 °C(lit.) Molecular Formula C6H5NO2 Molecular Weight 123.109 Flash Point 130.7±19.8 °C Exact Mass 123.032028 PSA 50.19000 LogP -0.10 Vapour Pressure 0.0±0.6 mmHg at 25°C Index of Refraction 1.571 InChIKey SIOXPEMLGUPBBT-UHFFFAOYSA-N SMILES O=C(O)c1ccccn1 Storage condition Store at RT. Water Solubility 887 g/L (20 ºC)
Use ofPCL 016 is a topical antiviral agent, which inhibits adenovirus replication in rabbit. Properties Articles57 Name picolinic acid Synonym More Synonyms 2-Picolinic acid Biological Activity Description PCL 016 is a topical antiviral agent, which inhibits adenovirus replication in rabbit. Related Catalog Natural Products >> Others Research Areas >> Infection Human Endogenous Metabolite Animal Admin Rabbits[1] 25 NZW rabbits are topically inoculated in both eyes, following corneal scarification, with 1.5 x 106 pfu/eye of Ad5. On day 1, the rabbits are divided into 6 topical treatment groups: I - 1.5% PCL 016 pH 7.0 (n=4); II - 0.8% PCL 016 pH 7.0 (n=4); III - 0.369% PCL 016 pH 7.0 (n=4); IV - 0.369% PCL 016 pH 4.0 (n=4); V - 0.5% Cidofovir (CDV) (n=4); VI - Control (saline) (n=5). PCL 016 and control rabbits are treated in both eyes 4 times daily for 7 days, while CDV rabbits are treated in both eyes twice daily for 7 days. All eyes are cultured for virus on days 0, 1, 3, 4, 5, 7, 9, 11, and 14[1]. References Chemical & Physical Properties Molecular Formula C6H5NO2 Exact Mass 123.032028 PSA 50.19000 LogP -0.10 Index of Refraction 1.571 InChIKey SIOXPEMLGUPBBT-UHFFFAOYSA-N Storage condition Store at RT.
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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