CAS Number126824-24-6
Synonyms1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrasodium salts (BAPTA Na); BAPTA tetrasodium salt hydrate; BAPTA,Tetrasodium salt; BAPTA tetrasodium; Tetrasodium 2,2',2'',2'''-[1,2-ethanediylbis(oxy-2,1-phenylenenitrilo)]tetraacetate; Tetrasodium 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetate; MFCD02683087; 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrasodium salt; 1,2-Bis(2-Aminophenoxy)-Ethane-N,N,N,N-Tetraacetic Acid Tetrasodium Salt; BAPTA, TETRASODIUM SALT
Molecular FormulaC22H20N2Na4O10
Molecular Weight564.36
Purity96+%
Boiling Point766.6ºC at 760 mmHg
Appearancebeige powder
EINECS0
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 126824-24-6 |
| Catalog No. | 2A-0150804 |
| Chinese Name | 1,2-双(2-氨基苯氧基)乙烷-N,N,N',N'-四乙酸四钠盐 |
| Synonyms | 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrasodium salts (BAPTA Na); BAPTA tetrasodium salt hydrate; BAPTA,Tetrasodium salt; BAPTA tetrasodium; Tetrasodium 2,2',2'',2'''-[1,2-ethanediylbis(oxy-2,1-phenylenenitrilo)]tetraacetate; Tetrasodium 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetate; MFCD02683087; 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrasodium salt; 1,2-Bis(2-Aminophenoxy)-Ethane-N,N,N,N-Tetraacetic Acid Tetrasodium Salt; BAPTA, TETRASODIUM SALT |
| Molecular Formula | C22H20N2Na4O10 |
| Molecular Weight | 564.36 |
| Purity | 96+ |
| Boiling Point | 766.6ºC at 760 mmHg |
| Appearance | beige powder |
| Storage Condition | Seal and store at -20ºC |
| Application | Tetrasodium BAPTA is a selective chelating agent for calcium. BAPTA tetrasodium is used as a calcium indicator and has high selectivity for magnesium and calcium. Tetrasodium BAPTA is widely used as a |
| EINECS | 0 |
| HTC | 0 |
| UN(IATA) | 0 |
| PubChem ID | 3156389 |
| MDL Number | MFCD00067691 |
| SMILES | O=C([O-])CN(CC(=O)[O-])c1ccccc1OCCOc1ccccc1N(CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Na+].[Na+] |
| InChI | InChI=1S/C22H24N2O10.4Na/c25-19(26)11-23(12-20(27)28)15-5-1-3-7-17(15)33-9-10-34-18-8-4-2-6-16(18)24(13-21(29)30)14-22(31)32;;;;/h1-8H,9-14H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32);;;;/q;4*+1/p-4 |
| InChI Key | ZWSMLJACYSGFKD-UHFFFAOYSA-J |
| NACRES Code | NA.25 |
| UNSPSC | 12352106 |
| Hazard Symbols | transportation |
| Bioactivity | BAPTA tetrasodium is a selective chelator for calcium. BAPTA tetrasodium, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrasodium is widely used as an intracellular buffer for investigating the effects of Ca2+ release from intracellular stores or influx via Ca2+-permeable channels in the plasma membrane. BAPTA tetrasodium can also inhibit phospholipase C activity independently of their role as Ca2+ chelators[1][2][3]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase Research Areas >> Others In Vitro BAPTA (0.3-30 μM; 1 h) can be used for the prevention of [Ca2+]-induced cell damage, but disturbe calcium signalling in isingle differentiated NH15-CA2 neuroblastoma and glioma hybrid cells[3]. BAPTA (0-10 mM) inhibits phospholipase C (PLC) activity in a dose-dependent manner, and is unrelated to Ca2+[2]. References [1]. R Y Tsien, et al. New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. Biochemistry. 1980 May 27;19(11):2396-404. [2]. Roger C Hardie, et al. Inhibition of phospholipase C activity in Drosophila photoreceptors by 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid (BAPTA) and di-bromo BAPTA. Cell Calcium. 2005 Dec;38(6):547-56. [3]. M B Collatz, et al. Intracellular calcium chelator BAPTA protects cells against toxic calcium overload but also alters physiological calcium responses. Cell Calcium Chemical & Physical Properties Boiling Point 766.6ºC at 760 mmHg Molecular Formula C22H20N2Na4O10 Molecular Weight 564.361 Flash Point 417.4ºC Exact Mass 564.070862 PSA 185.46000 InChIKey ZWSMLJACYSGFKD-UHFFFAOYSA-J SMILES O=C([O-])CN(CC(=O)[O-])c1ccccc1OCCOc1ccccc1N(CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Na+].[Na+] Storage condition -20°C |
| Use of | BAPTA tetrasodium is a selective chelator for calcium. BAPTA tetrasodium, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrasodium is widely used as an intracellular buffer for investigating the effects of Ca2+ release from intracellular stores or influx via Ca2+-permeable channels in the plasma membrane. BAPTA tetrasodium can also inhibit phospholipase C activity independently of their role as Ca2+ chelators[1][2][3]. Properties Name 1,2-Bis(2-aminophenoxy)-ethane-N,N,N,N-tetraacetic acid tetrasodium salt Synonym More Synonyms BAPTA tetrasodium Biological Activity Description BAPTA tetrasodium is a selective chelator for calcium. BAPTA tetrasodium, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrasodium is widely used as an intracellular buffer for investigating the effects of Ca2+ release from intracellular stores or influx via Ca2+-permeable channels in the plasma membrane. BAPTA tetrasodium can also inhibit phospholipase C activity independently of their role as Ca2+ chelators[1][2][3]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase Research Areas >> Others References [2]. Roger C Hardie, et al. Inhibition of phospholipase C activity in Drosophila photoreceptors by 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid (BAPTA) and di-bromo BAPTA. Cell Calcium. 2005 Dec;38(6):547-56. [3]. M B Collatz, et al. Intracellular calcium chelator BAPTA protects cells against toxic calcium overload but also alters physiological calcium responses. Cell Calcium Chemical & Physical Properties Molecular Formula C22H20N2Na4O10 Exact Mass 564.070862 PSA 185.46000 InChIKey ZWSMLJACYSGFKD-UHFFFAOYSA-J |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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