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9-HYDROXYRISPERIDONE structure, CAS 144598-75-4

9-HYDROXYRISPERIDONE

CAS Number144598-75-4

SynonymsUNII:838F01T721; 9-OH-risperidone; 9-Hydroxyrisperidone; Paliperidone; MFCD00871802

Molecular FormulaC23H27FN4O3

Molecular Weight426.48

Purity96+%

Density1.5±0.1 g/cm3

Boiling Point612.3±65.0 °C at 760 mmHg

Melting Point158-160°C

Flash Point

AppearanceOff-white to light orange solid

EINECS0

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Cat. No.: 2A-1150585 Purity: 96+%
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Quality Control of [ 144598-75-4 ] Purity: 96+% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number144598-75-4
Catalog No.2A-1150585
Chinese Name9－羟基利培酮
SynonymsUNII:838F01T721; 9-OH-risperidone; 9-Hydroxyrisperidone; Paliperidone; MFCD00871802
Molecular FormulaC23H27FN4O3
Molecular Weight426.48
Purity96+
Density1.5±0.1 g/cm3
Boiling Point612.3±65.0 °C at 760 mmHg
Melting Point158-160°C
AppearanceOff-white to light orange solid
Storage ConditionRoom temp
ApplicationPaliperidone (9-hydroxyrisperidone) is a dopamine receptor inhibitor.
EINECS0
HTC0
UN(IATA)0
PubChem ID10236700
SMILESCc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O
InChIInChI=1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3
InChI KeyPMXMIIMHBWHSKN-UHFFFAOYSA-N
NACRES CodeNA.24
UNSPSC41116107
Hazard Symbolstransportation
BioactivityPaliperidone (9-hydroxyrisperidone) is a dopamine antagonist of the atypical antipsychotic class of medications. IC50 value:Target: dopamine receptorin vitro: Paliperidone inhibited MK-801 induced neurotoxicity both in MTT metabolism assay (p<0.01) and in lactate dehydrogenase (LDH) activity assay (p<0.01). Moreover, paliperidone could significantly retard MK-801-mediated inhibition of neurite outgrowth (p<0.01) and reverse MK-801-induced decreases of gene expression and phosphorylation of Akt1 and GSK3β (both p<0.01). Furthermore, these protective effects of paliperidone were blocked by pretreatment with a PI3K inhibitor LY294002 [1]. paliperidone works finely at low concentrations (10 and 50 μM) against Aβ(25-35) and MPP(+) and solely protected SH-SY5Y from hydrogen peroxide. At 100 μM, paliperidone completely diminished cell reduction induced by different stressors, regardless of their dosages. Paliperidone was demonstrated with a higher oxidative stress-scavenging properties than other APDs in several aspects, such as generated bulk glutathione, low HNE, and protein carbonyl productions [2].in vivo: The 9OHRIS (4 mg/bwkg) was administred by gastric tube. Four groups were formed depending on the treatment: (1) control, (2) stress, (3) 9OHRIS, (4) stress and parallel 9OHRIS treatment (n=5-6). The expression of APP, MAPK1, β-actin mRNAs from the perfused brain samples was measured with real-time PCR technique [3].Male offspring were treated orally via drinking water with vehicle, risperidone (0.01mg/kg/day), or paliperidone (0.01mg/kg/day) between postnatal days 35 and 56 (periadolescence) and extracellular glutamate levels in the prefrontal cortex were determined by microdialysis at PD 56 [4]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease References [1]. Peng L, et al. Paliperidone protects prefrontal cortical neurons from damages caused by MK-801 via Akt1/GSK3β signaling pathway. Schizophr Res. 2013 Jun;147(1):14-23. [2]. Yang MC, et al. Neuroprotection of paliperidone on SH-SY5Y cells against β-amyloid peptide(25-35), N-methyl-4-phenylpyridinium ion, and hydrogen peroxide-induced cell death. Psychopharmacology (Berl). 2011 Oct;217(3):397-410. [3]. Kalman S, et al. 9-hydroxy-risperidone (9OHRIS) prevents stress-induced β-actin overexpression in rat hippocampus. Neuropsychopharmacol Hung. 2010 Sep;12(3):425-31. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 612.3±65.0 °C at 760 mmHg Melting Point 158-160°C Molecular Formula C23H27FN4O3 Molecular Weight 426.484 Flash Point 324.1±34.3 °C Exact Mass 426.206726 PSA 84.39000 LogP 1.52 Vapour Pressure 0.0±1.9 mmHg at 25°C Index of Refraction 1.692 InChIKey PMXMIIMHBWHSKN-UHFFFAOYSA-N SMILES Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O Storage condition Room temp
Use ofProperties Articles57 Name Paliperidone Synonym More Synonyms Paliperidone Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease References [2]. Yang MC, et al. Neuroprotection of paliperidone on SH-SY5Y cells against β-amyloid peptide(25-35), N-methyl-4-phenylpyridinium ion, and hydrogen peroxide-induced cell death. Psychopharmacology (Berl). 2011 Oct;217(3):397-410. [3]. Kalman S, et al. 9-hydroxy-risperidone (9OHRIS) prevents stress-induced β-actin overexpression in rat hippocampus. Neuropsychopharmacol Hung. 2010 Sep;12(3):425-31. Chemical & Physical Properties Molecular Formula C23H27FN4O3 Exact Mass 426.206726 PSA 84.39000 Index of Refraction 1.692 InChIKey PMXMIIMHBWHSKN-UHFFFAOYSA-N Storage condition Room temp
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Paliperidone) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Paliperidone) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Paliperidone) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is Correct safety instructions apply to this product. This information does not represent a warranty as to the properties of this product. See reverse side of invoice or packing slip.
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