![8-(2-(4-(2-METHOXYPHENYL)PIPERAZIN-1-YL)ETHYL)-8-AZASPIRO[4.5]DECANE-7,9-DIONE DIHYDROCHLORIDE structure, CAS 21102-95-4](/structures/150000/149963_1_21102_95_4.png)
CAS Number21102-95-4
SynonymsBMY 7378 dihydrochloride; 8-{2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl}-8-azaspiro[4.5]decane-7,9-dione dihydrochloride; MFCD00153771; 8-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione dihydrochloride; 8-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione dihydrochloride
Molecular FormulaC22H33Cl2N3O3
Molecular Weight458.42
Purity≥98 (HPLC)%
Boiling Point585.6ºC at 760 mmHg
Melting Point196.5-198.5 °C
Appearancesolid
EINECS0
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 21102-95-4 |
| Catalog No. | 2A-0149963 |
| Chinese Name | BMY 7378 dihydrochloride |
| Synonyms | BMY 7378 dihydrochloride; 8-{2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl}-8-azaspiro[4.5]decane-7,9-dione dihydrochloride; MFCD00153771; 8-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione dihydrochloride; 8-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione dihydrochloride |
| Molecular Formula | C22H33Cl2N3O3 |
| Molecular Weight | 458.42 |
| Purity | ≥98 (HPLC) |
| Boiling Point | 585.6ºC at 760 mmHg |
| Melting Point | 196.5-198.5 °C |
| Appearance | solid |
| Water Solubility | H2O: soluble |
| Application | BMY 7378 is a selective antagonist of α1D adrenergic receptor (α1D-AR). BMY 7378 binds to membranes expressing cloned rat α1D-AR with >100-fold higher affinity (Ki=2 nM) than to cloned rat α1A-AR (Ki= |
| EINECS | 0 |
| HTC | 2933599090 |
| UN(IATA) | 0 |
| PubChem ID | 24278080 |
| MDL Number | MFCD00153771 |
| SMILES | Cl.Cl.COc1ccccc1N2CCN(CC2)CCN3C(=O)CC4(CCCC4)CC3=O |
| InChI | 1S/C22H31N3O3.2ClH/c1-28-19-7-3-2-6-18(19)24-13-10-23(11-14-24)12-15-25-20(26)16-22(17-21(25)27)8-4-5-9-22;;/h2-3,6-7H,4-5,8-17H2,1H3;2*1H |
| InChI Key | NIBOMXUDFLRHRV-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | transportation |
| MSDS | msds/149963_1_21102_95_4.pdf |
| Bioactivity | BMY 7378 is a selective antagonist of α1D-adrenoceptor (α1D-AR). BMY 7378 binds to membranes expressing the cloned rat α1D-AR with a >100-fold higher affinity (Ki=2 nM) than binding to either the cloned rat α1A-AR (Ki=800 nM) or the hamster α1B-AR (Ki=600 nM). BMY 7378 is a 5-HT1A receptor partial agonist[1][2]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Target rat α1A-adrenergic receptor:800 nM (Ki) hamster alpha1B-adrenergic receptor:600 nM (Ki) rat alpha1D-adrenergic receptor:2 nM (Ki) 5-HT1A Receptor In Vitro BMY 7378 is selective for the alpha 1D-adrenoceptor subtype (pKi: hamster alpha 1b-adrenoceptor 6.2, human alpha 1b-adrenoceptor 7.2; bovine alpha 1c-adrenoceptor 6.1, human alpha 1c-adrenoceptor 6.6; rat alpha 1d-adrenoceptor 8.2, human alpha 1d-adrenoceptor 9.4) and has high affinity (pA2, 8.9) for rat aorta alpha 1-adrenoceptor[2]. References [1]. Piascik MT, et al. The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle. J Pharmacol Exp Ther. 1995;275(3):1583-1589. [2]. Goetz AS, et al. BMY 7378 is a selective antagonist of the D subtype of alpha 1-adrenoceptors. Eur J Pharmacol. 1995;272(2-3):R5-R6. Chemical & Physical Properties Boiling Point 585.6ºC at 760 mmHg Melting Point 196.5-198.5 °C Molecular Formula C22H33Cl2N3O3 Molecular Weight 458.422 Flash Point 307.9ºC Exact Mass 457.189911 PSA 53.09000 LogP 4.07140 Appearance of Characters solid | white Vapour Pressure 1.07E-13mmHg at 25°C InChIKey NIBOMXUDFLRHRV-UHFFFAOYSA-N SMILES COc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1.Cl.Cl Storage condition Store at RT Water Solubility H2O: soluble |
| Use of | BMY 7378 is a selective antagonist of α1D-adrenoceptor (α1D-AR). BMY 7378 binds to membranes expressing the cloned rat α1D-AR with a >100-fold higher affinity (Ki=2 nM) than binding to either the cloned rat α1A-AR (Ki=800 nM) or the hamster α1B-AR (Ki=600 nM). BMY 7378 is a 5-HT1A receptor partial agonist[1][2]. Properties Name 8-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-8-azaspiro[4.5]decane-7,9-dione,dihydrochloride Synonym More Synonyms BMY 7378 dihydrochloride Biological Activity Description BMY 7378 is a selective antagonist of α1D-adrenoceptor (α1D-AR). BMY 7378 binds to membranes expressing the cloned rat α1D-AR with a >100-fold higher affinity (Ki=2 nM) than binding to either the cloned rat α1A-AR (Ki=800 nM) or the hamster α1B-AR (Ki=600 nM). BMY 7378 is a 5-HT1A receptor partial agonist[1][2]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor rat α1A-adrenergic receptor:800 nM (Ki) hamster alpha1B-adrenergic receptor:600 nM (Ki) rat alpha1D-adrenergic receptor:2 nM (Ki) 5-HT1A Receptor References [1]. Piascik MT, et al. The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle. J Pharmacol Exp Ther. 1995;275(3):1583-1589. [2]. Goetz AS, et al. BMY 7378 is a selective antagonist of the D subtype of alpha 1-adrenoceptors. Eur J Pharmacol. 1995;272(2-3):R5-R6. Chemical & Physical Properties Exact Mass 457.189911 PSA 53.09000 LogP 4.07140 Appearance of Characters solid | white InChIKey NIBOMXUDFLRHRV-UHFFFAOYSA-N Storage condition Store at RT Water Solubility H2O: soluble |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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