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7,8-DIHYDROXY-2-PHENYL-4H-CHROMEN-4-ONE

Name: 7,8-DIHYDROXY-2-PHENYL-4H-CHROMEN-4-ONE
Brand: 2A Biotech
SKU: 2A-0148923

CAS Number38183-03-8

Synonyms7,8-dihydroxy-2-phenylchromen-4-one; 7,8-Dihydroxyflavone Hydrate; 7,8-Dihydroxy-2-phenyl-4H-chromen-4-one; EINECS 253-812-4; 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one; MFCD00006836; 7,8-Dihydroxyflavone

Molecular FormulaC15H10O4

Molecular Weight254.24 (anhydrous basis)

Purity≥98 (HPLC)%

Density1.4±0.1 g/cm3

Boiling Point494.4±45.0 °C at 760 mmHg

Melting Point243-246°C

Appearancesolid

EINECS253-812-4

MSDSChinese English

Symbol

Signal WordWarning

Cat. No.: 2A-0148923 Purity: ≥98 (HPLC)%

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Quality Control of [ 38183-03-8 ] Purity: ≥98 (HPLC)% SDS Specification MoL

Chemical & Physical Properties
CAS Number	38183-03-8
Catalog No.	2A-0148923
Chinese Name	7,8-二羟基黄酮
Synonyms	7,8-dihydroxy-2-phenylchromen-4-one; 7,8-Dihydroxyflavone Hydrate; 7,8-Dihydroxy-2-phenyl-4H-chromen-4-one; EINECS 253-812-4; 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one; MFCD00006836; 7,8-Dihydroxyflavone
Molecular Formula	C15H10O4
Molecular Weight	254.24 (anhydrous basis)
Purity	≥98 (HPLC)
Density	1.4±0.1 g/cm3
Boiling Point	494.4±45.0 °C at 760 mmHg
Melting Point	243-246°C
Appearance	solid
Storage Condition	Sealed, cool and dry storage
Application	7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological effects of brain-derived neurotrophic factor (BDNF). Shows therapeutic efficacy against various neurological d
EINECS	253-812-4
HTC	2914400090
UN(IATA)	0
PubChem ID	329798806
MDL Number	MFCD00006836
SMILES	Oc1ccc2C(=O)C=C(Oc2c1O)c3ccccc3
InChI	1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H
InChI Key	COCYGNDCWFKTMF-UHFFFAOYSA-N
NACRES Code	NA.77
UNSPSC	12352200
Hazard Symbols	transportation
MSDS	msds/148923_2_38183_03_8.pdf
Bioactivity	7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases[1]. Related Catalog Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Trk Receptor Research Areas >> Neurological Disease Target TrkB[1] In Vitro 7,8-Dihydroxyflavone (500 nM) protects the primary cortical neurons and locus coeruleus (LC) neurons from Aβ-induced toxicity and promotes dendritic growth and synaptogenesis[1]. In Vivo 7,8-Dihydroxyflavone (5 mg/kg/day) prevents synaptic loss and memory deficits in a mouse model of Alzheimer's Disease[1]. Administration of 7,8- dihydroxyflavone to mice activates TrkB in the brain, inhibits kainic acid-induced toxicity, decreases infarct volumes in stroke in a TrkBdependent manner, and is neuroprotective in an animal model of Parkinson disease[2]. References [1]. Zhang Z, et al. 7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology. 2014 Feb;39(3):638-50. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 494.4±45.0 °C at 760 mmHg Melting Point 243-246°C Molecular Formula C15H10O4 Molecular Weight 254.24 Flash Point 193.5±22.2 °C Exact Mass 254.057907 PSA 70.67000 LogP 2.51 Vapour Pressure 0.0±1.3 mmHg at 25°C Index of Refraction 1.699 InChIKey COCYGNDCWFKTMF-UHFFFAOYSA-N SMILES O=c1cc(-c2ccccc2)oc2c(O)c(O)ccc12 Storage condition Store at +4°C
Use of	7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases[1]. Properties Name 7,8-dihydroxyflavone Synonym More Synonyms 7,8-Dihydroxyflavone Biological Activity Description 7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases[1]. Related Catalog Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Trk Receptor Research Areas >> Neurological Disease In Vitro 7,8-Dihydroxyflavone (500 nM) protects the primary cortical neurons and locus coeruleus (LC) neurons from Aβ-induced toxicity and promotes dendritic growth and synaptogenesis[1]. References [1]. Zhang Z, et al. 7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology. 2014 Feb;39(3):638-50. Chemical & Physical Properties Molecular Formula C15H10O4 Exact Mass 254.057907 PSA 70.67000 Index of Refraction 1.699 InChIKey COCYGNDCWFKTMF-UHFFFAOYSA-N
Tax Rebate	9.0%
Supervision	none
Transport Info	Product name: Purity: 98.0%
MSDS Transport Info	Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available

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7,8-DIHYDROXY-2-PHENYL-4H-CHROMEN-4-ONE

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