| Chemical & Physical Properties | |
|---|---|
| CAS Number | 18474-59-4 |
| Catalog No. | 2A-0148563 |
| Chinese Name | 6-甲基吲哚-2-羧酸 |
| Synonyms | 6-Methyl-1H-indole-2-carboxylic acid |
| Molecular Formula | C10H9O2N1 |
| Molecular Weight | 175.19 |
| Purity | 96+ |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 411.5±25.0 °C at 760 mmHg |
| Melting Point | 220°C |
| Storage Condition | 2-8°C |
| Application | eIF4A3-IN-8 is a selective ATP-competitive eukaryotic initiation factor 4A3 (EIF4A4) inhibitor. eIF4A3-IN-8 can serve as a valuable chemical probe to elucidate the detailed functions of EIF4A4 and EJC |
| EINECS | 0 |
| HTC | 2933990090 |
| UN(IATA) | 0 |
| MDL Number | MFCD02664477 |
| SMILES | Cc1ccc2cc(C(=O)O)[nH]c2c1 |
| InChI Key | ZKGSVVHFMZASJS-UHFFFAOYSA-N |
| MSDS | msds/148563_1_18474_59_4.pdf |
| Use of | Properties Name 6-Methyl-1H-indole-2-carboxylic acid Synonym More Synonyms 6-Methyl-1H-indole-2-carboxylic acid Biological Activity Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Eukaryotic Initiation Factor (eIF) References [1]. Ito M, et al. Discovery of selective ATP-competitive eIF4A3 inhibitors. Bioorg Med Chem. 2017 Apr 1;25(7):2200-2209. Chemical & Physical Properties Molecular Formula C10H9NO2 Exact Mass 175.063324 PSA 53.09000 Index of Refraction 1.696 InChIKey ZKGSVVHFMZASJS-UHFFFAOYSA-N Safety Information Hazard Codes Xi: Irritant; HS Code 2933990090 Synthetic Route Total: 1 Page 2-Chloro-5-meth... CAS#:95-81-8 Pyruvic acid CAS#:127-17-3 6-Methyl-1H-ind... CAS#:18474-59-4 Literature: Journal of Medicinal Chemistry, , vol. 48, # 14 p. 4511 - 4525 (4-methyl-2-nit... CAS#:103264-29-5 6-Methyl-1H-ind... CAS#:18474-59-4 Literature: Gazzetta Chimica Italiana, , vol. 87, p. 949,953, 958 1,4-Dimethyl-2-... CAS#:89-58-7 6-Methyl-1H-ind... CAS#:18474-59-4 Literature: Journal of the American Chemical Society, , vol. 70, p. 3787 Precursor & DownStream Precursor 4 CAS#:95-81-8 2-Chloro-5-meth... CAS#:127-17-3 Pyruvic acid CAS#:103264-29-5 (4-methyl-2-nit... CAS#:89-58-7 1,4-Dimethyl-2-... DownStream 2 CAS#:35998-04-0 6-Methylgramine CAS#:3420-02-8 6-Methyl-1H-indole |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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