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6-METHOXYNICOTINAMIDE structure, CAS 7150-23-4

6-METHOXYNICOTINAMIDE

CAS Number7150-23-4

Synonyms6-methoxypyridine-3-carboxamide

Molecular FormulaC7H8N2O2

Molecular Weight152.15100

Purity96+%

Density1.213g/cm3

Boiling Point301.6ºC at 760mmHg

Melting Point

Flash Point

Appearance

EINECS0

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Cat. No.: 2A-0148515 Purity: 96+%
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Quality Control of [ 7150-23-4 ] Purity: 96+% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number7150-23-4
Catalog No.2A-0148515
Chinese Name6-甲氧基-3-吡啶羧胺
Synonyms6-methoxypyridine-3-carboxamide
Molecular FormulaC7H8N2O2
Molecular Weight152.15100
Purity96+
Density1.213g/cm3
Boiling Point301.6ºC at 760mmHg
Storage Condition-20°C, sealed, dry
ApplicationJBSNF-000088 (6-Methoxynicotinamide) is an analog of nicotinamide (NA) and a potent NNMT (nicotinamide N-methyltransferase) inhibitor with IC50s of 1.8 µM, 2.8 µM and 5.0 µM for human NNMT, monkey NNM
EINECS0
HTC2933399090
UN(IATA)0
SMILESCOc1ccc(C(N)=O)cn1
InChIInChI=1S/C7H8N2O2/c1-11-6-3-2-5(4-9-6)7(8)10/h2-4H,1H3,(H2,8,10)
InChI KeyKXDSMFBEVSJYRF-UHFFFAOYSA-N
BioactivityJBSNF-000088 (6-Methoxynicotinamide), a analog of nicotinamide (NA), is a potent Nicotinamide N-methyltransferase (NNMT) inhibitor with IC50s of 1.8 µM, 2.8 µM, and 5.0 µM for human NNMT, monkey NNMT and mouse NNMT, respectively. JBSNF-000088 inhibits NNMT activity, reduces MNA levels and drives insulin sensitization, glucose modulation and body weight reduction in animal models of metabolic disease[1]. Target IC50: 1.8 µM (human NNMT), 2.8 µM (monkey NNMT) and 5.0 µM (mouse NNMT)[1] In Vitro JBSNF-000088 (6-Methoxynicotinamide) has IC50 values are 1.6 and 6.3 µM for U2OS or differentiated 3T3L1 cells[1]. In Vivo JBSNF-000088 (6-Methoxynicotinamide) (50 mg/kg; oral route of administration for four weeks) shows statistically significant reduction in body weight (%) and leads to a statistically significant reduction in fed blood glucose on day 21[1]. JBSNF-000088 (50 mg/kg; oral gavage administration; twice daily for four weeks) leads to a statistically significant improvement in oral glucose tolerance on day 28 with glucose tolerance being normalized[1]. JBSNF-000088 (1 mg/kg; intravenous administration; for 4 hours) results in low plasma clearance of 21 mL/min▪kg and the volume of distribution at steady state of 0.7 L/kg, a very short plasma half-life of 0.5 hours upon intravenous administration[1]. JBSNF-000088 (10 mg/kg; oral gavage; for 4 hours) results in a Cmax of 3568 ng/mL with a Tmax value of 0.5 hours, indicating rapid absorption in the intestine, and half-life of 0.4 hours by oral gavage. The oral bioavailability is found to be approximately 40%[1]. Animal Model: Mice with high fat diet (HFD)-induced obesity[1] Dosage: 50 mg/kg Administration: Oral route of administration for four weeks; oral gavage administration and twice daily for four weeks Result: Showed statistically significant reduction in body weight (%) and led to a statistically significant reduction in fed blood glucose on day 21 by oral route of administration. Led to a statistically significant improvement in oral glucose tolerance on day 28 with glucose tolerance being normalized by oral gavage administration. Animal Model: C57BL/6 mice[1] Dosage: 1 mg/kg (Intravenous administration);10 mg/kg (oral gavage)(Pharmacokinetic Study) Administration: Intravenous administration and oral gavage; for 4 hours Result: Resulted in low plasma clearance of 21 mL/min▪kg and the volume of distribution at steady state of 0.7 L/kg, a very short plasma half-life of 0.5 h upon intravenous administration. Resulted in a Cmax of 3568 ng/mL with a Tmax value of 0.5 hours, indicating rapid absorption in the intestine, and half-life of 0.4 hours by oral gavage. References [1]. Kannt A, et al. A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders. Sci Rep. 2018 Feb 26;8(1):3660. Chemical & Physical Properties Density 1.213g/cm3 Boiling Point 301.6ºC at 760mmHg Molecular Formula C7H8N2O2 Molecular Weight 152.15100 Flash Point 136.2ºC Exact Mass 152.05900 PSA 65.21000 LogP 0.88940 Index of Refraction 1.55 InChIKey KXDSMFBEVSJYRF-UHFFFAOYSA-N SMILES COc1ccc(C(N)=O)cn1
Use ofJBSNF-000088 (6-Methoxynicotinamide), a analog of nicotinamide (NA), is a potent Nicotinamide N-methyltransferase (NNMT) inhibitor with IC50s of 1.8 µM, 2.8 µM, and 5.0 µM for human NNMT, monkey NNMT and mouse NNMT, respectively. JBSNF-000088 inhibits NNMT activity, reduces MNA levels and drives insulin sensitization, glucose modulation and body weight reduction in animal models of metabolic disease[1]. Properties Name 6-Methoxynicotinamide Synonym More Synonyms JBSNF-000088 Biological Activity Description JBSNF-000088 (6-Methoxynicotinamide), a analog of nicotinamide (NA), is a potent Nicotinamide N-methyltransferase (NNMT) inhibitor with IC50s of 1.8 µM, 2.8 µM, and 5.0 µM for human NNMT, monkey NNMT and mouse NNMT, respectively. JBSNF-000088 inhibits NNMT activity, reduces MNA levels and drives insulin sensitization, glucose modulation and body weight reduction in animal models of metabolic disease[1]. IC50: 1.8 µM (human NNMT), 2.8 µM (monkey NNMT) and 5.0 µM (mouse NNMT)[1] References [1]. Kannt A, et al. A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders. Sci Rep. 2018 Feb 26;8(1):3660. Chemical & Physical Properties Molecular Formula C7H8N2O2 Exact Mass 152.05900 PSA 65.21000 LogP 0.88940 Index of Refraction 1.55 InChIKey KXDSMFBEVSJYRF-UHFFFAOYSA-N
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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