![6-FLUORO-2-(2'-FLUORO-[1,1'-BIPHENYL]-4-YL)-3-METHYLQUINOLINE-4-CARBOXYLIC ACID structure, CAS 96187-53-0](/structures/150000/148094_1_96187_53_0.png)
CAS Number96187-53-0
SynonymsBrequinarum [INN-Latin]; 6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid; brequinarum [Latin]; 6-Fluoro-2-(2'-fluoro-4-biphenylyl)-3-methyl-4-quinolinecarboxylic acid; 6-Fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid; Brequinar; Brequinar [INN]; brequinar potassium; Dup 785; BREQUINAR SODIUM
Molecular FormulaC23H15O2N1F2
Molecular Weight375.37
Purity96+%
Density1.3±0.1 g/cm3
Boiling Point550.9±50.0 °C at 760 mmHg
Melting Point317 °C
AppearanceSolid;White to Light yellow powder to crystal
EINECS0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 96187-53-0 |
| Catalog No. | 2A-0148094 |
| Chinese Name | 布喹那 |
| Synonyms | Brequinarum [INN-Latin]; 6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid; brequinarum [Latin]; 6-Fluoro-2-(2'-fluoro-4-biphenylyl)-3-methyl-4-quinolinecarboxylic acid; 6-Fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid; Brequinar; Brequinar [INN]; brequinar potassium; Dup 785; BREQUINAR SODIUM |
| Molecular Formula | C23H15O2N1F2 |
| Molecular Weight | 375.37 |
| Purity | 96+ |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 550.9±50.0 °C at 760 mmHg |
| Melting Point | 317 °C |
| Appearance | Solid;White to Light yellow powder to crystal |
| Storage Condition | 0-10°C; avoid heating |
| Application | Brequinar is a potent dihydroorotate dehydrogenase inhibitor and broad-spectrum antiviral agent. |
| EINECS | 0 |
| HTC | 2933499090 |
| UN(IATA) | 0 |
| MDL Number | MFCD00866437 |
| SMILES | Cc1c(-c2ccc(-c3ccccc3F)cc2)nc2ccc(F)cc2c1C(=O)O |
| InChI | InChI=1S/C23H15F2NO2.Na/c1-13-21(23(27)28)18-12-16(24)10-11-20(18)26-22(13)15-8-6-14(7-9-15)17-4-2-3-5-19(17)25;/h2-12H,1H3,(H,27,28);/q;+1/p-1 |
| InChI Key | PHEZJEYUWHETKO-UHFFFAOYSA-N |
| MSDS | msds/148094_1_96187_53_0.pdf |
| Use of | Brequinar is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses. Properties Name 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid Synonym More Synonyms Brequinar Biological Activity Description Brequinar is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cancer Research Areas >> Inflammation/Immunology Research Areas >> Infection References [1]. Schnellrath LC, et al. Potent antiviral activity of brequinar against the emerging Cantagalo virus in cell culture. Int J Antimicrob Agents. 2011 Nov;38(5):435-41. [2]. Qing M, et al. Characterization of dengue virus resistance to brequinar in cell culture. Antimicrob Agents Chemother. 2010 Sep;54(9):3686-95. [3]. Xu X, et al. In vitro and in vivo mechanisms of action of the antiproliferative and immunosuppressive agent, brequinar sodium. J Immunol. 1998 Jan 15;160(2):846-53. Chemical & Physical Properties Molecular Formula C23H15F2NO2 Exact Mass 375.107086 PSA 50.19000 Index of Refraction 1.645 InChIKey PHEZJEYUWHETKO-UHFFFAOYSA-N Safety Information Hazard Codes Xi HS Code 2933499090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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