CAS Number56-41-7
SynonymsL-ARANINE; MFCD00064410; Fmoc-L-Ala-OH; H-L-ALA-OH; H-ALA-OH; L-ALA; ALANINE; ALA; L-Alanine; Alanin; EINECS 200-273-8; Ritalanine; L-alamine
Molecular FormulaC3H7NO2
Molecular Weight89.09
Purity≥98 (TLC)%
Density1.2±0.1 g/cm3
Boiling Point212.9±23.0 °C at 760 mmHg
Melting Point314.5 °C (dec.)(lit.)
Appearancepowder
EINECS200-273-8
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 56-41-7 |
| Catalog No. | 2A-9014703 |
| Chinese Name | L-丙氨酸 |
| Synonyms | L-ARANINE; MFCD00064410; Fmoc-L-Ala-OH; H-L-ALA-OH; H-ALA-OH; L-ALA; ALANINE; ALA; L-Alanine; Alanin; EINECS 200-273-8; Ritalanine; L-alamine |
| Molecular Formula | C3H7NO2 |
| Molecular Weight | 89.09 |
| Purity | ≥98 (TLC) |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 212.9±23.0 °C at 760 mmHg |
| Melting Point | 314.5 °C (dec.)(lit.) |
| Appearance | powder |
| Water Solubility | 166.5 g/L (25 ºC) |
| Storage Condition | Store in a sealed, cool and dry place. |
| Application | L-Alanine is a non-essential amino acid that participates in sugar and acid metabolism, enhances immunity, and provides energy to muscle tissue, the brain, and the central nervous system. |
| EINECS | 200-273-8 |
| HTC | 2930901000 |
| PubChem ID | 24891260 |
| MDL Number | MFCD00064410 |
| SMILES | C[C@H](N)C(O)=O |
| InChI | 1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 |
| InChI Key | QNAYBMKLOCPYGJ-REOHCLBHSA-N |
| Beilstein/REAXYS | 1720248 |
| NACRES Code | NA.26 |
| eCl@ss | 32160406 |
| UNSPSC | 12352209 |
| Hazard Symbols | Transport |
| MSDS | msds/14703_1_56_41_7.pdf |
| Bioactivity | L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system. Related Catalog Research Areas >> Metabolic Disease Research Areas >> Neurological Disease Natural Products >> Others Target Human Endogenous Metabolite In Vitro The viability of both hiPSCs, 201B7 cells and ehiPSCs decrease with an increase in L-Alanine concentration, and reach 7.5±1.3% and 3.7±0.7% respectively at 1.2 M of L-Alanine. On the other hand, no decrease in the viability of hFBs and hSkMCs are observed. Although the viability of iCMs slightly decreases along with the increase of the L-Alanine concentration, viability of iCMs at 1.2 M concentration of L-Alanine, 49.4±6.9%, is significantly higher than that of undifferentiated iPSCs, 201B7 cells and ehiPSCs (p< 0.01). The viability of hiPSCs, 201B7 cells and ehiPSCs, drastically decrease even after 2 or 4 h treatment. In contrast, the viability of hFBs fails to decrease at 1, 2, and 4 h and shows a small decrease at 24 h treatment. The viability of 201B7 cells in suspension culture decreases to 11.8±6.0% following treatment with 1.2 M L-Alanine for 2 h, whereas that of hFBs is 72.9±14.2%[1]. Cell Assay To investigate the selective removal of hiPSCs from differentiated cells by the high L-Alanine medium, two types of hiPSCs, 201B7 hiPSCs (201B7 cells) and an hiPSC line derived by episomal system (ehiPSCs) are used, along with normal human dermal fibroblasts (hFBs), human skeletal muscle cells (hSkMCs) and hiPSC-derived cardiomyocytes (iCMs) as differentiated cells. The cells are incubated in a medium supplemented with L-Alanine at various concentrations (0-1.2 M) or treatment times (1-24 h). The medium is replaced with a normal medium and the relative cell viability is measured after 24 h[1]. References [1]. Nagashima T, et al. Selective Elimination of Human Induced Pluripotent Stem Cells Using Medium with High Concentration of L-Alanine. Sci Rep. 2018 Aug 20;8(1):12427. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 212.9±23.0 °C at 760 mmHg Melting Point 314.5 °C (dec.)(lit.) Molecular Formula C3H7NO2 Molecular Weight 89.093 Flash Point 82.6±22.6 °C Exact Mass 89.047676 PSA 63.32000 LogP -0.68 Vapour Pressure 0.1±0.9 mmHg at 25°C Index of Refraction 1.460 InChIKey QNAYBMKLOCPYGJ-REOHCLBHSA-N SMILES CC(N)C(=O)O Water Solubility 166.5 g/L (25 ºC) |
| Use of | L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system. Properties Articles216 Name L-alanine Synonym More Synonyms L-alanine Biological Activity Description L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system. Related Catalog Research Areas >> Metabolic Disease Research Areas >> Neurological Disease Natural Products >> Others Human Endogenous Metabolite References [1]. Nagashima T, et al. Selective Elimination of Human Induced Pluripotent Stem Cells Using Medium with High Concentration of L-Alanine. Sci Rep. 2018 Aug 20;8(1):12427. Chemical & Physical Properties Molecular Formula C3H7NO2 Exact Mass 89.047676 PSA 63.32000 LogP -0.68 Index of Refraction 1.460 InChIKey QNAYBMKLOCPYGJ-REOHCLBHSA-N SMILES CC(N)C(=O)O |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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