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Home > Products > Pharmaceutical R&D Materials > Heterocyclic Building Blocks > 6-AMINO-1H-BENZO[DE]ISOQUINOLINE-1,3(2H)-DIONE
6-AMINO-1H-BENZO[DE]ISOQUINOLINE-1,3(2H)-DIONE structure, CAS 1742-95-6

6-AMINO-1H-BENZO[DE]ISOQUINOLINE-1,3(2H)-DIONE

CAS Number1742-95-6

Synonyms6-aminobenzo[de]isoquinoline-1,3-dione; EINECS 217-092-5; 4-Amino-1,8-naphthalimide; 6-Amino-1H-benzo[de]isoquinoline-1,3(2H)-dione; MFCD00001892

Molecular FormulaC12H8N2O2

Molecular Weight212.20

Purity96+%

Density1.105 g/mL at 25ºC(lit.)

Boiling Point544.1ºC at 760 mmHg

Melting Point360 °C

Flash Point

Appearancesolid

EINECS217-110-1

MSDSChineseEnglish

Symboltransportation

Signal WordWarning

Cat. No.: 2A-0146698 Purity: 96+%
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Quality Control of [ 1742-95-6 ] Purity: 96+% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number1742-95-6
Catalog No.2A-0146698
Chinese Name4-氨基-1,8-萘二胺
Synonyms6-aminobenzo[de]isoquinoline-1,3-dione; EINECS 217-092-5; 4-Amino-1,8-naphthalimide; 6-Amino-1H-benzo[de]isoquinoline-1,3(2H)-dione; MFCD00001892
Molecular FormulaC12H8N2O2
Molecular Weight212.20
Purity96+
Density1.105 g/mL at 25ºC(lit.)
Boiling Point544.1ºC at 760 mmHg
Melting Point360 °C
Appearancesolid
Storage ConditionSealed storage at -20°C
Application4-Aminonaphthalimide is a potent PARP inhibitor that can enhance the cytotoxicity of gamma radiation in cancer cells [1].
EINECS217-110-1
HTC0
UN(IATA)0
PubChem ID24277696
MDL NumberMFCD00006921
SMILESNc1ccc2C(=O)NC(=O)c3cccc1c23
InChI1S/C12H8N2O2/c13-9-5-4-8-10-6(9)2-1-3-7(10)11(15)14-12(8)16/h1-5H,13H2,(H,14,15,16)
InChI KeySSMIFVHARFVINF-UHFFFAOYSA-N
NACRES CodeNA.83
UNSPSC12352204
Hazard Symbolstransportation
MSDSmsds/146698_1_1742_95_6.pdf
Bioactivity4-Aminonaphthalimide is a potent PARP inhibitor and potentiates the cytotoxicity of γ-radiation in cancer cells[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> PARP References [1]. Schlicker A, et al. 4-Amino-1,8-naphthalimide: a novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer. Int J Radiat Biol. 1999 Jan;75(1):91-100. Chemical & Physical Properties Density 1.105 g/mL at 25ºC(lit.) Boiling Point 544.1ºC at 760 mmHg Melting Point 360ºC Molecular Formula C12H8N2O2 Molecular Weight 212.20 Flash Point 282.8ºC Exact Mass 212.05900 PSA 75.95000 LogP 1.64270 Vapour Pressure 6.75E-12mmHg at 25°C Index of Refraction 1.764 InChIKey SSMIFVHARFVINF-UHFFFAOYSA-N SMILES Nc1ccc2c3c(cccc13)C(=O)NC2=O
Use of4-Aminonaphthalimide is a potent PARP inhibitor and potentiates the cytotoxicity of γ-radiation in cancer cells[1]. Properties Articles32 Name 4-amino-1,8-naphthalimide Synonym More Synonyms 4-AMINO-1,8-NAPHTHALIMIDE Biological Activity Description 4-Aminonaphthalimide is a potent PARP inhibitor and potentiates the cytotoxicity of γ-radiation in cancer cells[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> PARP References [1]. Schlicker A, et al. 4-Amino-1,8-naphthalimide: a novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer. Int J Radiat Biol. 1999 Jan;75(1):91-100. Chemical & Physical Properties Molecular Formula C12H8N2O2 Exact Mass 212.05900 PSA 75.95000 LogP 1.64270 Index of Refraction 1.764 InChIKey SSMIFVHARFVINF-UHFFFAOYSA-N
Transport InfoProduct name: Purity: 95.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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