![6-(4-(2-(PIPERIDIN-1-YL)ETHOXY)PHENYL)-3-(PYRIDIN-4-YL)PYRAZOLO[1,5-A]PYRIMIDINE structure, CAS 866405-64-3](/structures/150000/146382_1_866405_64_3.png)
CAS Number866405-64-3
SynonymsDorsomorphin; BML-275; 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine; 6-{4-[2-(1-Piperidinyl)ethoxy]phenyl}-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine
Molecular FormulaC24H25N5O
Molecular Weight399.49
Purity≥98 (HPLC)%
Density1.3±0.1 g/cm3
Appearancepowder
EINECS0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 866405-64-3 |
| Catalog No. | 2A-0146382 |
| Chinese Name | 6-[4-(2-哌啶-1-基乙氧基)苯基]-3-吡啶-4-基吡唑并[1,5-A]嘧啶 |
| Synonyms | Dorsomorphin; BML-275; 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine; 6-{4-[2-(1-Piperidinyl)ethoxy]phenyl}-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine |
| Molecular Formula | C24H25N5O |
| Molecular Weight | 399.49 |
| Purity | ≥98 (HPLC) |
| Density | 1.3±0.1 g/cm3 |
| Appearance | powder |
| Storage Condition | 0-10°C; store in inert gas; avoid air, heat |
| Application | Dorsomorphin is a potent ATP-competitive and selective AMPK inhibitor with Ki of 109±16 nM. |
| EINECS | 0 |
| HTC | 2933990090 |
| UN(IATA) | 0 |
| PubChem ID | 24898658 |
| MDL Number | MFCD08705402 |
| SMILES | C1CCN(CC1)CCOc2ccc(cc2)-c3cnc4c(cnn4c3)-c5ccncc5 |
| InChI | 1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2 |
| InChI Key | XHBVYDAKJHETMP-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 51111800 |
| MSDS | msds/146382_1_866405_64_3.pdf |
| Use of | Properties Articles104 Name dorsomorphin Synonym More Synonyms dorsomorphin Biological Activity Related Catalog Signaling Pathways >> Epigenetics >> AMPK Signaling Pathways >> PI3K/Akt/mTOR >> AMPK Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer AMPK:109 nM (Ki) In Vivo Administration of Dorsomorphin over 24 h leads to a 60% increase in total serum iron concentrations. Dorsomorphin treatment is therefore effective in reducing basal levels of hepcidin expression and increasing serum iron concentrations in adult mice[3]. References [1]. Zhou G, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. 2001 Oct;108(8):1167-74. [2]. Saito S, et al. Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling. PLoS One. 2012;7(9):e45845. [3]. Yu PB, et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol. 2008 Jan;4(1):33-41. [4]. Chen L, et al. Activating AMPK to Restore Tight Junction Assembly in Intestinal Epithelium and to Attenuate Experimental Colitis by Metformin. Front Pharmacol. 2018 Jul 16;9:761. Chemical & Physical Properties Molecular Formula C24H25N5O Exact Mass 399.205902 PSA 55.55000 Index of Refraction 1.670 InChIKey XHBVYDAKJHETMP-UHFFFAOYSA-N Safety Information Signal Word Warning Hazard Statements H302-H312-H332 Precautionary Statements P280 Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves Hazard Codes Xn: Harmful; RIDADR NONH for all modes of transport HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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