CAS Number18711-16-5
Synonyms6,7-Dichloro-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-one; NS-309; 6,7-dichloro-1H-indole-2,3-dione-3-oxime; (3E)-6,7-Dichloro-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-one; 6,7-dichloroisatin 3-oxime; 1H-Indole-2,3-dione, 6,7-dichloro-, 3-oxime; 6,7-Dichloro-1H-indole-2,3-dione 3-oxime; 3-Oxime-6,7-dichloro-1H-indole-2,3-dione; NS309
Molecular FormulaC8H4Cl2N2O2
Molecular Weight231.04
Purity≥98 (HPLC)%
Density1.8±0.1 g/cm3
Appearancesolid
EINECS0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 18711-16-5 |
| Catalog No. | 2A-0146118 |
| Chinese Name | 3-肟-6,7-二氯-1H-吲哚-2,3-二酮 |
| Synonyms | 6,7-Dichloro-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-one; NS-309; 6,7-dichloro-1H-indole-2,3-dione-3-oxime; (3E)-6,7-Dichloro-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-one; 6,7-dichloroisatin 3-oxime; 1H-Indole-2,3-dione, 6,7-dichloro-, 3-oxime; 6,7-Dichloro-1H-indole-2,3-dione 3-oxime; 3-Oxime-6,7-dichloro-1H-indole-2,3-dione; NS309 |
| Molecular Formula | C8H4Cl2N2O2 |
| Molecular Weight | 231.04 |
| Purity | ≥98 (HPLC) |
| Density | 1.8±0.1 g/cm3 |
| Appearance | solid |
| Storage Condition | 2-8℃ |
| Application | NS309 is a positive regulator of calcium-activated potassium channels (KCa2 and KCa3.1), which can enhance the sensitivity of calcium ions and is inactive on BK channels. |
| EINECS | 0 |
| HTC | 2933790090 |
| UN(IATA) | 0 |
| PubChem ID | 329818681 |
| MDL Number | MFCD06798346 |
| SMILES | O\N=C1\C(=O)Nc2c(Cl)c(Cl)ccc12 |
| InChI | 1S/C8H4Cl2N2O2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12-14/h1-2,14H,(H,11,12,13) |
| InChI Key | CVOUSAVHMDXCKG-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/146118_1_18711_16_5.pdf |
| Use of | Properties Name 6,7-dichloro-3-(hydroxyamino)indol-2-one Synonym More Synonyms NS309 Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Cardiovascular Disease References [1]. Stankevicius, Edgaras; Dalsgaard, Thomas; Kroigaard, Christel et al. Opening of small and intermediate calcium-activated potassium channels induces relaxation mainly mediated by nitric-oxide release in large arteries and endothelium-derived hyperpolarizin [2]. Seear, Rachel V.; Lew, Virgilio L. IKCa agonist (NS309)-elicited all-or-none dehydration response of human red blood cells is cell-age dependent. Cell Calcium (2011), 50(5), 444-448. [3]. Dalsgaard, T.; Kroigaard, C.; Misfeldt, M. Openers of small conductance calcium-activated potassium channels selectively enhance NO-mediated bradykinin vasodilatation in porcine retinal arterioles. British Journal of Pharmacology (2010), 160(6), 1496-1508 [4]. Broendum, E.; Kold-Petersen, H.; Simonsen, U.; Aalkjaer, C. NS309 restores EDHF-type relaxation in mesenteric small arteries from type 2 diabetic ZDF rats. British Journal of Pharmacology (2010), 159(1), 154-165. Chemical & Physical Properties Exact Mass 229.964981 PSA 61.69000 Index of Refraction 1.742 Storage condition 2-8℃ Safety Information Signal Word Warning Hazard Statements H315-H319-H335 Precautionary Statements P261-P305 + P351 + P338 Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves Hazard Codes Xi: Irritant; Safety Phrases S26 RIDADR NONH for all modes of transport HS Code 2933790090 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 9.0% Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0% |
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