CAS Number79-14-1
SynonymsGlycocide; QV1Q; CHC-22; 2-Hydroxyethanoic acid; GlyPure 99; hydroxyacetic acid; Glykolsure; Glycol acid; GlyPure 70; EINECS 201-180-5; a-Hydroxyacetic acid; Glycollic acid; Glycolic acid; methoxycarboxylic acid; GLYCOLATE; GlyPure; MFCD00004312; glycolic
Molecular FormulaHOCH2COOH
Molecular Weight76.05
Purity99%
Density1.4±0.1 g/cm3
Boiling Point(169 °C 336 °F at 998 hPa)
Melting Point75-80 °C (lit.)
Appearancesolid
EINECS201-180-5
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 79-14-1 |
| Catalog No. | 2A-9014589 |
| Chinese Name | 羟基乙酸 |
| Synonyms | Glycocide; QV1Q; CHC-22; 2-Hydroxyethanoic acid; GlyPure 99; hydroxyacetic acid; Glykolsure; Glycol acid; GlyPure 70; EINECS 201-180-5; a-Hydroxyacetic acid; Glycollic acid; Glycolic acid; methoxycarboxylic acid; GLYCOLATE; GlyPure; MFCD00004312; glycolic |
| Molecular Formula | HOCH2COOH |
| Molecular Weight | 76.05 |
| Purity | 99 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | (169 °C 336 °F at 998 hPa) |
| Melting Point | 75-80 °C (lit.) |
| Appearance | solid |
| Water Solubility | SOLUBLE |
| Storage Condition | 1. This product should be sealed and stored in a c |
| Packaging | II |
| Application | Glycolic Acid is an inhibitor of tyrosinase, which can inhibit the formation of melanin, thereby lightening the color of the skin. |
| EINECS | 201-180-5 |
| HTC | 2918199090 |
| PubChem ID | 24847624 |
| MDL Number | MFCD00004312 |
| SMILES | OCC(O)=O |
| InChI | 1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5) |
| InChI Key | AEMRFAOFKBGASW-UHFFFAOYSA-N |
| Beilstein/REAXYS | 1209322 |
| NACRES Code | NA.21 |
| eCl@ss | 39021303 |
| UNSPSC | 12352100 |
| Hazard Symbols | 8 |
| MSDS | msds/14589_1_79_14_1.pdf |
| Bioactivity | Glycolic Acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase Natural Products >> Others Research Areas >> Metabolic Disease Target Human Endogenous Metabolite In Vitro Different concentrations of Glycolic Acid (GA) or LA (300 and 500 mg/mL) are tested on the growth of mouse and human melanoma cells. Both types of cells grow well, even in the presence of 300 mg/mL of each chemical for 5 days. However, 500 mg/mL Glycolic Acid inhibits the cell growth of mouse melanoma cells (41%) and humanmelanoma cells (27%), and 500 mg/mL of LA inhibits the growth of mouse melanoma cells (36%)[1]. Cell Assay HM3KO pigmented human melanoma cells and B16 mouse melanoma cells are cultured in Dulbecco's modified Eagles medium supplemented with 10%fetal calf serum and appropriate amounts of antibiotics and fungizone were dissolved at a concentration of 100mg/mL in distilled water. These chemicals (e.g., Glycolic Acid ) are added to the cell cultures at final concentrations of 300 or 500 mg/mL every 2 days for 5 days[1]. References [1]. Usuki A, et al. The inhibitory effect of glycolic acid and lactic acid on melanin synthesis in melanoma cells. Exp Dermatol. 2003;12 Suppl 2:43-50. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 265.6±13.0 °C at 760 mmHg Melting Point 75-80 °C(lit.) Molecular Formula C2H4O3 Molecular Weight 76.051 Flash Point 128.7±16.3 °C Exact Mass 76.016045 PSA 57.53000 LogP -1.05 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.450 InChIKey AEMRFAOFKBGASW-UHFFFAOYSA-N SMILES O=C(O)CO Storage condition 2-8°C Stability Stable. Incompatible with bases, oxidizing agents and reducing agents. Water Solubility SOLUBLE |
| Use of | Glycolic Acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour. Properties Articles112 Name glycolic acid Synonym More Synonyms Glycolic acid Biological Activity Description Glycolic Acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase Natural Products >> Others Research Areas >> Metabolic Disease Human Endogenous Metabolite References [1]. Usuki A, et al. The inhibitory effect of glycolic acid and lactic acid on melanin synthesis in melanoma cells. Exp Dermatol. 2003;12 Suppl 2:43-50. Chemical & Physical Properties Molecular Formula C2H4O3 Exact Mass 76.016045 PSA 57.53000 LogP -1.05 Index of Refraction 1.450 InChIKey AEMRFAOFKBGASW-UHFFFAOYSA-N SMILES O=C(O)CO Stability Stable. Incompatible with bases, oxidizing agents and reducing agents. Water Solubility SOLUBLE |
| Tax Rebate | 9.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Chemical name |
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