
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 885272-55-9 |
| Catalog No. | 2A-0142377 |
| Chinese Name | 5-吡啶-4-基-1H-吲唑 |
| Synonyms | INDAZOLE,5-(4-PYRIDINYL); 5-(4-Pyridinyl)-1H-indazole; 5-(Pyridin-4-yl)-1H-indazole; 1H-Indazole,5-(4-pyridinyl) |
| Molecular Formula | C12H9N3 |
| Molecular Weight | 195.22 |
| Purity | 96+ |
| Storage Condition | -20°C, sealed, dry |
| Application | TG693 is an orally active CLK1 inhibitor. TG693 regulates mutated exon 31 of the dystrophin gene in vivo. TG693 is being studied in Duchenne muscular dystrophy (DMD). |
| EINECS | 0 |
| HTC | 2933990090 |
| UN(IATA) | 0 |
| MDL Number | MFCD04114684 |
| SMILES | c1cc(-c2ccc3[nH]ncc3c2)ccn1 |
| InChI Key | CILGVAIRQUNMLT-UHFFFAOYSA-N |
| MSDS | msds/142377_1_885272_55_9.pdf |
| Use of | TG693 is an orally active inhibitor of CLK1. TG693 regulates the mutated exon 31 of the dystrophin gene in vivo. TG693 is used in Duchenne muscular dystrophy (DMD) research[1]. Properties Name 5-pyridin-4-yl-1h-indazole Synonym More Synonyms TG693 Biological Activity Description TG693 is an orally active inhibitor of CLK1. TG693 regulates the mutated exon 31 of the dystrophin gene in vivo. TG693 is used in Duchenne muscular dystrophy (DMD) research[1]. Related Catalog Research Areas >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> CDK References [1]. Sako Y, et al. Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy. Sci Rep. 2017 May 30;7:46126. Chemical & Physical Properties Molecular Formula C12H9N3 Exact Mass 195.08000 PSA 41.57000 LogP 2.62490 InChIKey CILGVAIRQUNMLT-UHFFFAOYSA-N Safety Information HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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| 5-(PYRIDIN-3-YL)ISOXAZOLE-3-CARBOXYLIC ACID | 893638-39-6 | 2A-0142371 |
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| 5-(PYRIDIN-4-YL)-1H-INDOLE | 90679-35-9 | 2A-0142378 |
| 5-(PYRIDIN-4-YL)ISOXAZOLE-3-CARBOXYLIC ACID | 893638-41-0 | 2A-0142379 |
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