![5-(2-ETHOXYPHENYL)-1-METHYL-3-PROPYL-1H-PYRAZOLO[4,3-D]PYRIMIDIN-7(6H)-ONE structure, CAS 139756-21-1](/structures/150000/141718_1_139756_21_1.png)
CAS Number139756-21-1
Synonyms5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one; 5-(2-ethoxyphenyl)-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one; 5-(2-Ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]-7-pyrimidinone; 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one; 5-(2-Ethoxyphenyl)-l-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolol- 4,3-dipyrimidin-7-one
Molecular FormulaC17H20O2N4
Molecular Weight312.37
Purity96+%
Density1.3±0.1 g/cm3
Boiling Point504ºC at 760 mmHg
Melting Point141-145ºC(lit.)
AppearanceSolid;White to Light yellow to Light orange powder to crystal
EINECS0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 139756-21-1 |
| Catalog No. | 2A-1141718 |
| Chinese Name | 5-(2-乙氧苯基)-1-甲基-3-丙基-1,6-二氢-7H-吡唑并[4,3-D]嘧啶-7-酮 |
| Synonyms | 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one; 5-(2-ethoxyphenyl)-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one; 5-(2-Ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]-7-pyrimidinone; 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one; 5-(2-Ethoxyphenyl)-l-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolol- 4,3-dipyrimidin-7-one |
| Molecular Formula | C17H20O2N4 |
| Molecular Weight | 312.37 |
| Purity | 96+ |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 504ºC at 760 mmHg |
| Melting Point | 141-145ºC(lit.) |
| Appearance | Solid;White to Light yellow to Light orange powder to crystal |
| Storage Condition | room temperature, dry |
| Application | PDE5-IN-7 (compound 8) is a selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 5nM, while the IC50 of PDE1 is 300nM [1]. |
| EINECS | 0 |
| HTC | 2933990090 |
| UN(IATA) | 0 |
| MDL Number | MFCD04088989 |
| MSDS | msds/141718_1_139756_21_1.pdf |
| Use of | PDE5-IN-7 (compound 8) is a selective phosphodiesterase 5 (PDE 5) inhibitor with an IC50 value of 5 nM, while an IC50 of 300 nM for PDE 1[1]. Properties Name 5-(2-Ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one Synonym More Synonyms Biological Activity Description PDE5-IN-7 (compound 8) is a selective phosphodiesterase 5 (PDE 5) inhibitor with an IC50 value of 5 nM, while an IC50 of 300 nM for PDE 1[1]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Others PDE5:5 nM (IC50) PDE1:300 nM (IC50) In Vitro PDE5-IN-7 (compound 15, Desild) can be detected and isolated from Sildenafil (HY-15025) derivatives[2]. Chemical & Physical Properties Molecular Formula C17H20N4O2 Exact Mass 312.158630 PSA 72.80000 Index of Refraction 1.632 Safety Information Signal Word Warning Hazard Statements H315-H319-H335 Precautionary Statements P261-P305 + P351 + P338 Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves Hazard Codes Xi: Irritant; Safety Phrases S26-S36 RIDADR NONH for all modes of transport WGK Germany 3 HS Code 2933990090 Synthetic Route 4-(2-Ethoxybenz... 139756-03-9 5-(2-Ethoxyphen... 139756-21-1 Literature: Khan, Khalid Mohammed; Maharvi, Ghulam Murtaza; Choudhary, Muhammad Iqbal; Atta-Ur-Rahman; Perveen, Shahnaz Journal of Heterocyclic Chemistry, 2005 , vol. 42, # 6 p. 1085 - 1093 2-Ethoxybenzald... 4-Amino-1-methy... 139756-02-8 5-(2-Ethoxyphen... 139756-21-1 Literature: Abdel-Jalil, Raid J.; Khanfar, Monther; Al-Gharabli, Samer; El-Abadelah, Mustafa M.; Eichele, Klaus; Anwar, Muhammad Usman; Voelter, Wolfgang Heterocycles, 2005 , vol. 65, # 8 p. 1821 - 1827 4-Amino-1-methy... 139756-02-8 5-(2-Ethoxyphen... 139756-21-1 Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 17 p. 3900 - 3907 Precursor & DownStream Precursor 10 CAS#:139756-03-9 4-(2-Ethoxybenz... CAS#:613-69-4 2-Ethoxybenzaldehyde CAS#:139756-02-8 4-Amino-1-methy... CAS#:42926-52-3 2-Ethoxybenzoyl... DownStream 6 CAS#:371959-09-0 Norneosildenafil CAS#:479074-06-1 5-(2-ethoxyphen... CAS#:1058653-74-9 5-[5-(2-Chloroa... CAS#:139755-85-4 Hydroxyhomo Sil... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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