| Chemical & Physical Properties | |
|---|---|
| CAS Number | 105628-72-6 |
| Catalog No. | 2A-0141565 |
| Chinese Name | 羟基法舒 |
| Synonyms | hfs; hydroxyfasudil; ha 1100 |
| Molecular Formula | C14H17O3N3S1 |
| Molecular Weight | 307.37 |
| Purity | 96+ |
| Density | 1.329g/cm3 |
| Boiling Point | 613.7ºC at 760mmHg |
| Storage Condition | 2-8°C |
| Application | Hydroxyfasudil is a ROCK inhibitor that inhibits the activities of ROCK1 and ROCK2 with IC50 values of 0.73 and 0.72 μM, respectively. |
| EINECS | 0 |
| HTC | 2933990090 |
| UN(IATA) | 0 |
| MDL Number | MFCD01752417 |
| SMILES | O=c1[nH]ccc2c(S(=O)(=O)N3CCCNCC3)cccc12 |
| InChI | InChI=1S/C14H17N3O3S/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17/h1,3-5,7,15H,2,6,8-10H2,(H,16,18) |
| InChI Key | ZAVGJDAFCZAWSZ-UHFFFAOYSA-N |
| MSDS | msds/141565_1_105628_72_6.pdf |
| Use of | Hydroxyfasudil is a ROCK inhibitor, with IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively. Properties Name 5-(1,4-diazepan-1-ylsulfonyl)-2H-isoquinolin-1-one Synonym More Synonyms Hydroxyfasudil Biological Activity Description Hydroxyfasudil is a ROCK inhibitor, with IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK Signaling Pathways >> Stem Cell/Wnt >> ROCK Signaling Pathways >> TGF-beta/Smad >> ROCK Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology ROCK2:0.72 μM (IC50) ROCK1:0.73 μM (IC50) PKA:37 μM (IC50) References [1]. Rikitake Y, et al. Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke. 2005 Oct;36(10):2251-7. Epub 2005 Sep 1. [2]. Masago T, et al. Effect of the rho-kinase inhibitor hydroxyfasudil on bladder overactivity: an experimental rat model. Int J Urol. 2009 Oct;16(10):842-7. [3]. Saito M, et al. Hydroxyfasudil ameliorates penile dysfunction in the male spontaneously hypertensive rat. Pharmacol Res. 2012 Oct;66(4):325-31. Chemical & Physical Properties Molecular Formula C14H17N3O3S Exact Mass 307.09900 PSA 90.65000 LogP 1.85960 InChIKey ZAVGJDAFCZAWSZ-UHFFFAOYSA-N Safety Information HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Nutritional Ingredients | ||
|---|---|---|
| 4-METHYL-1,4-DIAZEPAN-5-ONE | 172314-56-6 | 2A-0140377 |
| 4-METHYL-1,4-DIAZEPAN-5-ONE HYDROCHLORIDE | 329794-41-4 | 2A-0140378 |
| 4-O-BENZYL-1,2:3,4-DI-O-CYCLOHEXYLIDENE-D-MYO-INOSITOL | 116907-54-1 | 2A-0140860 |
| 4-O-BENZYL-1,2:5,6-DI-O-CYCLOHEXYLIDENE-L-MYO-INOSITOL | 124601-98-5 | 2A-0140861 |
| 4-TRIFLUOROMETHYL-L-PHENYLALANINE HYDROCHLORIDE | 122839-50-3 | 2A-0141140 |
| 5-OXO-[1,4]DIAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER | 190900-21-1 | 2A-0145932 |
| 6-METHYL-1,4-DIAZEPANE | 89582-17-2 | 2A-0148557 |
| AZEPAN-2,5-DIONE | 37637-20-0 | 2A-0150753 |
| BENZYL (2-OXOAZEPAN-3-YL)CARBAMATE | 108875-45-2 | 2A-0151011 |
| BENZYL 2-(HYDROXYMETHYL)-1,4-OXAZEPANE-4-CARBOXYLATE | 1256633-21-2 | 2A-0151096 |
| Browse all Nutritional Ingredients products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS