CAS Number131123-76-7
Synonyms5,7-DICHLOROKYNURENIC ACID; 5,7-Dichlorokynurenic acid sodium salt; 5,7-Dichorokynurenic acid; 5,7-dichloro-4-hydroxy-2-carboxyquinoline; MFCD00674925; 5,7-DCKA; 5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID; 5,7-Dichloro-4-hydroxy-2-quinolinecarboxylic acid; 5,7-DICHLOROKYNURENIC ACID POTENT EXCITA TORY AMI; 2-Quinolinecarboxylic acid,5,7-dichloro-4-hydroxy; 5,7-dichlorokynurenic acid sodium; 5,7-Dichloroquinurenic acid; 5,7-Dichlor-4-hydroxy-chinolin-2-carbonsaeure
Molecular FormulaC10H5Cl2NO3
Molecular Weight258.06
Purity96+%
Appearancesolid | light yellow
EINECS0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 131123-76-7 |
| Catalog No. | 2A-0141475 |
| Chinese Name | 5,7-二氯犬尿喹啉酸 |
| Synonyms | 5,7-DICHLOROKYNURENIC ACID; 5,7-Dichlorokynurenic acid sodium salt; 5,7-Dichorokynurenic acid; 5,7-dichloro-4-hydroxy-2-carboxyquinoline; MFCD00674925; 5,7-DCKA; 5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID; 5,7-Dichloro-4-hydroxy-2-quinolinecarboxylic acid; 5,7-DICHLOROKYNURENIC ACID POTENT EXCITA TORY AMI; 2-Quinolinecarboxylic acid,5,7-dichloro-4-hydroxy; 5,7-dichlorokynurenic acid sodium; 5,7-Dichloroquinurenic acid; 5,7-Dichlor-4-hydroxy-chinolin-2-carbonsaeure |
| Molecular Formula | C10H5Cl2NO3 |
| Molecular Weight | 258.06 |
| Purity | 96+ |
| Appearance | solid | light yellow |
| Water Solubility | 0.1 M NaOH: soluble |
| Storage Condition | Desiccate at RT |
| Application | 5,7-Dichlorokynuric acid (5,7-DCKA) is a selective competitive antagonist of the glycine site of the NMDA receptor, with a KB of 65 nM. 5,7-Dichlorokynurenic acid, a derivative of kynurenic acid, can |
| EINECS | 0 |
| HTC | 2933499090 |
| UN(IATA) | 0 |
| MDL Number | C10H5Cl2NO3 |
| SMILES | O=C(O)c1cc(=O)c2c(Cl)cc(Cl)cc2[nH]1 |
| InChI | InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16) |
| InChI Key | BGKFPRIGXAVYNX-UHFFFAOYSA-N |
| MSDS | msds/141475_1_131123_76_7.pdf |
| Use of | 5,7-Dichlorokynurenic acid (5,7-DCKA) is a selective and competitive antagonist of the glycine site on NMDA receptor with a KB of 65 nM. 5,7-Dichlorokynurenic acid, a derivative of kynurenic acid, reduced NMDA-induced neuron injury in rat cortical cell cultures[1]. Properties Name 5,7-dichlorokynurenic acid sodium salt Synonym More Synonyms 5,7-Dichlorokynurenic acid Biological Activity Description 5,7-Dichlorokynurenic acid (5,7-DCKA) is a selective and competitive antagonist of the glycine site on NMDA receptor with a KB of 65 nM. 5,7-Dichlorokynurenic acid, a derivative of kynurenic acid, reduced NMDA-induced neuron injury in rat cortical cell cultures[1]. Related Catalog Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR References [1]. D McNamara, et al. 5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors. Neurosci Lett. 1990 Nov 27;120(1):17-20. Chemical & Physical Properties Exact Mass 256.96500 PSA 70.42000 LogP 2.94540 Appearance of Characters solid | light yellow InChIKey BGKFPRIGXAVYNX-UHFFFAOYSA-N Storage condition Desiccate at RT Water Solubility 0.1 M NaOH: soluble Safety Information Hazard Codes Xi Safety Phrases S26-S36 WGK Germany 3 HS Code 2933499090 Precursor & DownStream Precursor 2 CAS#:157848-08-3 5,7-DICHLORO-4-... CAS#:626-43-7 3,5-Dichloroaniline DownStream 3 CAS#:23834-01-7 4,5,7-Trichloro... CAS#:171850-29-6 5,7-dichloroqui... CAS#:5437-27-4 N-(5,7-dichloro... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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