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Home > Products > Pharmaceuticals & Life Science > Biotechnology & Diagnostics > 5'-O-TRITYL-2'-DEOXYURIDINE
5'-O-TRITYL-2'-DEOXYURIDINE structure, CAS 14270-73-6

5'-O-TRITYL-2'-DEOXYURIDINE

CAS Number14270-73-6

Synonyms1-[(2R,4S,5R)-4-hydroxy-5-(trityloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; 5'-Trt-2'-dU

Molecular FormulaC28H26O5N2

Molecular Weight470.52

Purity96+%

Density1.3g/cm3

Boiling Point

Melting Point204-205 °C

Flash Point

Appearance

EINECS0

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Cat. No.: 2A-0141192 Purity: 96+%
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Quality Control of [ 14270-73-6 ] Purity: 96+% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number14270-73-6
Catalog No.2A-0141192
Chinese Name5'-O-三苯甲基-2'-脱氧尿苷
Synonyms1-[(2R,4S,5R)-4-hydroxy-5-(trityloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; 5'-Trt-2'-dU
Molecular FormulaC28H26O5N2
Molecular Weight470.52
Purity96+
Density1.3g/cm3
Melting Point204-205 °C
Storage Condition2-8℃, dry
Application5'-O-triphenylmethyl-2'-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogues have broad antitumor activity and target indolent lymphoid malignancies. The anti-cancer mechanism in th
EINECS0
HTC2934999090
UN(IATA)0
MDL NumberMFCD11113892
SMILESOC1CC(OC1COC(c2ccccc2)(c3ccccc3)c4ccccc4)N5C=CC(=O)NC5=O
InChIInChI=1S/C28H26N2O5/c31-23-18-26(30-17-16-25(32)29-27(30)33)35-24(23)19-34-28(20-10-4-1-5-11-20,21-12-6-2-7-13-21)22-14-8-3-9-15-22/h1-17,23-24,26,31H,18-19H2,(H,29,32,33)
InChI KeyInChIKey=JJJNFNLUKYZAKI-UHFFFAOYSA-N
MSDSmsds/141192_1_14270_73_6.pdf
Use of5'-O-Triphenylmethyl-2'-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. Properties Name 5'-O-Trityl-2'-deoxyuridine Synonym More Synonyms 5'-Trt-2'-dU Biological Activity Description 5'-O-Triphenylmethyl-2'-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog References [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. Chemical & Physical Properties Molecular Formula C28H26N2O5 Exact Mass 470.18400 PSA 93.55000 LogP 3.19370 Index of Refraction 1.63 Safety Information HS Code 2934999090 Synthetic Route Total: 1 Page 2'-deoxyuridine CAS#:951-78-0 Triphenylmethyl... CAS#:76-83-5 5'-Trt-2'-dU CAS#:14270-73-6 Literature: Nguyen, Corinne; Kasinathan, Ganasan; Leal-Cortijo, Isabel; Musso-Buendia, Alexander; Kaiser, Marcel; Brun, Reto; Ruiz-Perez, Luis M.; Johansson, Nils G.; Gonzalez-Pacanowska, Dolores; Gilbert, Ian H. Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5942 - 5954 2'-deoxyuridine CAS#:951-78-0 4-Methoxytriphe... CAS#:14470-28-1 5'-Trt-2'-dU CAS#:14270-73-6 Literature: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) Patent: EP1674104 A1, 2006 ; Location in patent: Page/Page column 11; 19 ; 2'-deoxyuridine CAS#:951-78-0 Triphenylmethyl... CAS#:76-83-5 2'-deoxy-3',5'-... CAS#:1140622-58-7 5'-Trt-2'-dU CAS#:14270-73-6 Literature: Chatelain, Gregory; Debing, Yannick; De Burghgraeve, Tine; Zmurko, Joanna; Saudi, Milind; Rozenski, Jef; Neyts, Johan; Van Aerschot, Arthur European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 249 - 255
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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