| Chemical & Physical Properties | |
|---|---|
| CAS Number | 56010-88-9 |
| Catalog No. | 2A-0140417 |
| Chinese Name | 4-甲基吡唑盐酸盐 |
| Synonyms | Fomepizole Hydrochloride; MFCD00012707; 4-methyl-1H-pyrazole,hydrochloride |
| Molecular Formula | C4H7ClN2 |
| Molecular Weight | 118.56 |
| Purity | ≥95 |
| Melting Point | 157-159 °C |
| Appearance | powder |
| Storage Condition | room temperature |
| Application | Formopyrazole hydrochloride (4-methylpyrazole) is a potent inhibitor of cytochrome P450 (CYP2E1). Formopyrazole hydrochloride is a competitive inhibitor of alcohol dehydrogenase. Formopyrazole hydroch |
| EINECS | 0 |
| HTC | 2933199090 |
| UN(IATA) | 0 |
| PubChem ID | 24278534 |
| MDL Number | MFCD00012707 |
| SMILES | Cl.Cc1cn[nH]c1 |
| InChI | 1S/C4H6N2.ClH/c1-4-2-5-6-3-4;/h2-3H,1H3,(H,5,6);1H |
| InChI Key | PUCXJHNDMYZOHG-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352100 |
| Hazard Symbols | transportation |
| MSDS | msds/140417_1_56010_88_9.pdf |
| Bioactivity | Fomepizole (4-Methylpyrazole) hydrochloride is a potent cytochrome P450 (CYP2E1) inhibitor. Fomepizole hydrochloride is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole hydrochloride blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole hydrochloride has the potential for an antidote for ethylene glycol or methanol poisoning[1][2][3]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Metabolic Disease Target CYP2E1 In Vivo Pretreatment with Fomepizole (4-Methylpyrazole; 25 mg/kg; IP) prolongs ethanol neurobehavioral toxicity in CD-1 mice[4] Animal Model: Male CD-1 mice weighing 18-25 g[4] Dosage: 25 mg/kg Administration: IP; single dose Result: Decreased the dose of ethanol (1-5 g/kg; IP) at which 50% of the animals failed a particular outcome test (toxic dose 50; TD50). References [1]. Casavant MJ. Fomepizole in the treatment of poisoning. Pediatrics. 2001 Jan;107(1):170. [2]. Lepik KJ, et al. Adverse drug events associated with the antidotes for methanol and ethylene glycol poisoning: a comparison of ethanol and fomepizole. Ann Emerg Med. 2009 Apr;53(4):439-450.e10. [3]. Garrett Rampon, et al. Use of fomepizole as an adjunct in the treatment of acetaminophen overdose: a case series. Toxicology Communications. Volume 4, 2020 - Issue 1. [4]. Páez AM, et al. Effects of 4-methylpyrazole on ethanol neurobehavioral toxicity in CD-1 mice. Acad Emerg Med. 2004 Aug;11(8):820-6. Chemical & Physical Properties Melting Point 157-159 °C Molecular Formula C4H7ClN2 Molecular Weight 118.56500 Exact Mass 118.03000 PSA 28.68000 LogP 1.52010 InChIKey PUCXJHNDMYZOHG-UHFFFAOYSA-N SMILES Cc1cn[nH]c1.Cl |
| Use of | Fomepizole (4-Methylpyrazole) hydrochloride is a potent cytochrome P450 (CYP2E1) inhibitor. Fomepizole hydrochloride is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole hydrochloride blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole hydrochloride has the potential for an antidote for ethylene glycol or methanol poisoning[1][2][3]. Properties Articles34 Name 4-Methylpyrazole hydrochloride Synonym More Synonyms 4-Methylpyrazole hydrochloride Biological Activity Description Fomepizole (4-Methylpyrazole) hydrochloride is a potent cytochrome P450 (CYP2E1) inhibitor. Fomepizole hydrochloride is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole hydrochloride blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole hydrochloride has the potential for an antidote for ethylene glycol or methanol poisoning[1][2][3]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Metabolic Disease References [1]. Casavant MJ. Fomepizole in the treatment of poisoning. Pediatrics. 2001 Jan;107(1):170. [2]. Lepik KJ, et al. Adverse drug events associated with the antidotes for methanol and ethylene glycol poisoning: a comparison of ethanol and fomepizole. Ann Emerg Med. 2009 Apr;53(4):439-450.e10. [3]. Garrett Rampon, et al. Use of fomepizole as an adjunct in the treatment of acetaminophen overdose: a case series. Toxicology Communications. Volume 4, 2020 - Issue 1. Chemical & Physical Properties Exact Mass 118.03000 PSA 28.68000 LogP 1.52010 InChIKey PUCXJHNDMYZOHG-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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