| Chemical & Physical Properties | |
|---|---|
| CAS Number | 160003-66-7 |
| Catalog No. | 2A-0140026 |
| Chinese Name | 4-碘-3-硝基-苯甲酰胺 |
| Synonyms | Iniparib (BSI-201); 4-Iodo-3-nitrobenzamide; Iniparib; BSI-201 |
| Molecular Formula | C7H5IN2O3 |
| Molecular Weight | 262.04 |
| Purity | 97 |
| Density | 2.1±0.1 g/cm3 |
| Boiling Point | 344.8±32.0 °C at 760 mmHg |
| Melting Point | 107-112 °C |
| Appearance | solid |
| Water Solubility | DMSO: soluble5mg/mL, clear |
| Storage Condition | room temp |
| Application | Iniparib (BSI-201) is an irreversible PARP1 inhibitor for triple-negative breast cancer research. |
| EINECS | 0 |
| HTC | 2924299090 |
| UN(IATA) | 0 |
| PubChem ID | 329763911 |
| MDL Number | MFCD01009500 |
| SMILES | COc1ccc(C=O)cc1I |
| InChI | 1S/C8H7IO2/c1-11-8-3-2-6(5-10)4-7(8)9/h2-5H,1H3 |
| InChI Key | RVWOHBWQJGLXIJ-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| MSDS | msds/140026_1_160003_66_7.pdf |
| Use of | Iniparib (BSI-201) is an irreversible inhibitor of PARP1, used in the research of triple negative breast cancer. Properties Name 4-Iodo-3-nitrobenzamide Synonym More Synonyms Iniparib (BSI-201) Biological Activity Description Iniparib (BSI-201) is an irreversible inhibitor of PARP1, used in the research of triple negative breast cancer. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> PARP Signaling Pathways >> Epigenetics >> PARP Research Areas >> Cancer In Vitro Iniparib nonselectively modifies cysteine-containing proteins in tumor cells[1]. Iniparib (100 μM) weakly inhibits SSB repair, and the inhibition can be reversed by knockdown of PARP1[2]. Iniparib in combination with cisplatin is cytotoxic to Myc/MDA-231 with EMT changes[3]. References [1]. Liu X, et al. Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor. Clin Cancer Res. 2012 Jan 15;18(2):510-23. [2]. Ma W, et al. Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6590-5. [3]. Yin S, et al. Myc mediates cancer stem-like cells and EMT changes in triple negative breast cancers cells. PLoS One. 2017 Aug 17;12(8):e0183578. Chemical & Physical Properties Molecular Formula C7H5IN2O3 Exact Mass 291.934479 PSA 88.91000 Appearance of Characters white to beige Index of Refraction 1.696 InChIKey MDOJTZQKHMAPBK-UHFFFAOYSA-N Storage condition room temp Safety Information Signal Word Warning Hazard Statements H302-H319 Precautionary Statements P305 + P351 + P338 Hazard Codes Xn Risk Phrases 22-36-43 Safety Phrases 26 RIDADR NONH for all modes of transport HS Code 2924299090 Synthetic Route Methyl 4-iodo-3... CAS#:89976-27-2 Iniparib (BSI-201) CAS#:160003-66-7 Aqueous ammonia CAS#:1336-21-6 4-Iodo-3-nitrob... CAS#:35674-27-2 Iniparib (BSI-201) CAS#:160003-66-7 Literature: Octamer, Inc. Patent: US5877185 A1, 1999 ; 4-Bromo-3-nitro... CAS#:879-93-6 Iniparib (BSI-201) CAS#:160003-66-7 Literature: Cant, Alastair A.; Bhalla, Rajiv; Pimlott, Sally L.; Sutherland, Andrew Chemical Communications, 2012 , vol. 48, # 33 p. 3993 - 3995 Precursor & DownStream Precursor 4 CAS#:89976-27-2 Methyl 4-iodo-3... CAS#:1336-21-6 Aqueous ammonia CAS#:35674-27-2 4-Iodo-3-nitrob... CAS#:879-93-6 4-Bromo-3-nitro... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| 4-IODO-1-METHOXY-2-(PENTYLOXY)BENZENE | 9119-73-9 | 2A-0139980 |
| 4-IODO-2,5-DIMETHYLANILINE | 117832-13-0 | 2A-0139998 |
| 4-IODO-2,7-NAPHTHYRIDIN-1-AMINE | 959558-53-3 | 2A-0140000 |
| 4-IODO-2-NITROBENZOIC ACID | 116529-62-5 | 2A-0140011 |
| 4-IODO-3-METHYLBENZOIC ACID | 52107-87-6 | 2A-0140023 |
| 4-IODO-3-NITROBENZONITRILE | 101420-79-5 | 2A-0140028 |
| 4-IODO-3-NITROPHENOL | 113305-56-9 | 2A-0140029 |
| 4-IODO-5-NITROBENZENE-1,2-DIAMINE | 113269-12-8 | 2A-0140035 |
| 4-IODO-N,N-DIMETHYLBENZAMIDE | 24167-53-1 | 2A-0140043 |
| 4-IODO-N-METHYLANILINE HYDROCHLORIDE | 84250-74-8 | 2A-0140045 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS