CAS Number1672-63-5
SynonymsMFCD00003143; 1-phenyl-2,3-dimethyl-4-hydroxy-pyrazoline-5-on; 4-hydroxy-1,5-dimethyl-2-phenyl-1,2-dihydro-3h-pyrazol-3-one; 4-Hydroxy-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one; 1-Phenyl-2,3-dimethyl-4-hydroxy-5-pyrazolone; Prestwick_270; hydroxy-4 antipyrine; 1,2-dihydro-4-hydroxy-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one; Antipyrine,4-hydroxy; 4-Hydroxyantipyrine
Molecular FormulaC11H12N2O2
Molecular Weight204.23
Purity99%
Density1.294g/cm3
Boiling Point314.3ºC at 760mmHg
Melting Point184-186 °C (lit.)
EINECS0
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1672-63-5 |
| Catalog No. | 2A-0139742 |
| Chinese Name | 4-羟基-1,5-二甲基-2-苯基-1,2-二氢-3H-吡唑-3-酮 |
| Synonyms | MFCD00003143; 1-phenyl-2,3-dimethyl-4-hydroxy-pyrazoline-5-on; 4-hydroxy-1,5-dimethyl-2-phenyl-1,2-dihydro-3h-pyrazol-3-one; 4-Hydroxy-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one; 1-Phenyl-2,3-dimethyl-4-hydroxy-5-pyrazolone; Prestwick_270; hydroxy-4 antipyrine; 1,2-dihydro-4-hydroxy-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one; Antipyrine,4-hydroxy; 4-Hydroxyantipyrine |
| Molecular Formula | C11H12N2O2 |
| Molecular Weight | 204.23 |
| Purity | 99 |
| Density | 1.294g/cm3 |
| Boiling Point | 314.3ºC at 760mmHg |
| Melting Point | 184-186 °C (lit.) |
| Storage Condition | Room temperature, avoid light, ventilated and dry |
| Application | 4-Hydroxyantipyrine (4-hydroxybennarone; NSC 174055) is the main metabolite of antipyrine (HY-B0171) and can be used as a biodistribution promoter. 4-Hydroxyantipyrine can increase the concentration r |
| EINECS | 0 |
| HTC | 2933990090 |
| UN(IATA) | 0 |
| PubChem ID | 24846917 |
| MDL Number | MFCD00003143 |
| SMILES | CN1N(c2ccccc2)C(=O)C(O)=C1C |
| InChI | 1S/C11H12N2O2/c1-8-10(14)11(15)13(12(8)2)9-6-4-3-5-7-9/h3-7,14H,1-2H3 |
| InChI Key | SKVPTPMWXJSBTF-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | transportation |
| MSDS | msds/139742_1_1672_63_5.pdf |
| Bioactivity | 4-Hydroxyantipyrine (4-Hydroxyphenazone; NSC 174055) is the major metabolite of Antipyrine (HY-B0171), can be as a biodistribution promoter. 4-Hydroxyantipyrine can increase distribution of concentration ratio of Citicoline and Antipyrine in the brain[1][2]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others In Vitro 4-Hydroxyantipyrine increase the tissue-to-plasma concentration ratio of Citicoline in the brain and liver and that of thiopental sodium in the brain, liver, and heart[1]. 4-Hydroxyantipyrine enhances the blood-brain barrier (BBB) permeability of Antipyrine considering to be concerned with the increase of the Kp value of Antipyrine in the brain[2]. References [1]. Ohkawa Y, et al. Effects of 4-hydroxyantipyrine and its 4-O-sulfate on antipyrine as biodistribution promoter. Biol Pharm Bull. 2001 May;24(5):529-34. [2]. Ohkawa Y, et al. Application of 4-hydroxyantipyrine and acetaminophen O-sulfate as biodistribution promoter. Biol Pharm Bull. 2001 Dec;24(12):1404-10. Chemical & Physical Properties Density 1.294g/cm3 Boiling Point 314.3ºC at 760mmHg Melting Point 184-186ºC(lit.) Molecular Formula C11H12N2O2 Molecular Weight 204.22500 Flash Point 143.9ºC Exact Mass 204.09000 PSA 47.16000 LogP 1.19000 Vapour Pressure 0.000199mmHg at 25°C Index of Refraction 1.63 |
| Use of | 4-Hydroxyantipyrine (4-Hydroxyphenazone; NSC 174055) is the major metabolite of Antipyrine (HY-B0171), can be as a biodistribution promoter. 4-Hydroxyantipyrine can increase distribution of concentration ratio of Citicoline and Antipyrine in the brain[1][2]. Properties Articles29 Name 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one Synonym More Synonyms 4-hydroxyantipyrine Biological Activity Description 4-Hydroxyantipyrine (4-Hydroxyphenazone; NSC 174055) is the major metabolite of Antipyrine (HY-B0171), can be as a biodistribution promoter. 4-Hydroxyantipyrine can increase distribution of concentration ratio of Citicoline and Antipyrine in the brain[1][2]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others In Vitro 4-Hydroxyantipyrine increase the tissue-to-plasma concentration ratio of Citicoline in the brain and liver and that of thiopental sodium in the brain, liver, and heart[1]. 4-Hydroxyantipyrine enhances the blood-brain barrier (BBB) permeability of Antipyrine considering to be concerned with the increase of the Kp value of Antipyrine in the brain[2]. References [1]. Ohkawa Y, et al. Effects of 4-hydroxyantipyrine and its 4-O-sulfate on antipyrine as biodistribution promoter. Biol Pharm Bull. 2001 May;24(5):529-34. [2]. Ohkawa Y, et al. Application of 4-hydroxyantipyrine and acetaminophen O-sulfate as biodistribution promoter. Biol Pharm Bull. 2001 Dec;24(12):1404-10. Chemical & Physical Properties Molecular Formula C11H12N2O2 Exact Mass 204.09000 PSA 47.16000 LogP 1.19000 Index of Refraction 1.63 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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