CAS Number24735-18-0
SynonymsBenzoic acid, 4-hydroxy-3,5-dimethoxy-, 4-[(aminoiminomethyl)amino]butyl ester, hydrochloride (1:1); 4-Carbamimidamidobutyl 4-hydroxy-3,5-dimethoxybenzoate hydrochloride (1:1); 4-hydroxy-3,5-dimethoxy-benzoic acid-(4-guanidino-butyl ester),hydrochloride; 4-Guanidinobutyl 4-hydroxy-3,5-dimethoxybenzoate hydrochloride; 4-Hydroxy-3,5-dimethoxy-benzoesaeure-(4-guanidino-butylester),Hydrochlorid; 4-(diaminomethylideneamino)butyl 4-hydroxy-3,5-dimethoxy-benzoate hydrochloride; leonurine hydrochloride; Leonurin monohydrochloride; Leonurine (hydrochloride)
Molecular FormulaC14H22ClN3O5
Molecular Weight347.79
Purity≥95.0 (HPLC)%
Melting Point194 ºC
EINECS0
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 24735-18-0 |
| Catalog No. | 2A-0139705 |
| Chinese Name | 盐酸益母草碱 |
| Synonyms | Benzoic acid, 4-hydroxy-3,5-dimethoxy-, 4-[(aminoiminomethyl)amino]butyl ester, hydrochloride (1:1); 4-Carbamimidamidobutyl 4-hydroxy-3,5-dimethoxybenzoate hydrochloride (1:1); 4-hydroxy-3,5-dimethoxy-benzoic acid-(4-guanidino-butyl ester),hydrochloride; 4-Guanidinobutyl 4-hydroxy-3,5-dimethoxybenzoate hydrochloride; 4-Hydroxy-3,5-dimethoxy-benzoesaeure-(4-guanidino-butylester),Hydrochlorid; 4-(diaminomethylideneamino)butyl 4-hydroxy-3,5-dimethoxy-benzoate hydrochloride; leonurine hydrochloride; Leonurin monohydrochloride; Leonurine (hydrochloride) |
| Molecular Formula | C14H22ClN3O5 |
| Molecular Weight | 347.79 |
| Purity | ≥95.0 (HPLC) |
| Melting Point | 194 ºC |
| Storage Condition | -20°C |
| Application | Leonurine hydrochloride is an alkaloid isolated from Herba leonuri and has antioxidant and anti-inflammatory activities. |
| EINECS | 0 |
| HTC | 2925290090 |
| UN(IATA) | 0 |
| MDL Number | MFCD09953249 |
| SMILES | Cl.N(CCCCOC(=O)c1cc(c(c(c1)OC)O)OC)C(=N)N |
| InChI | 1S/C14H21N3O5.ClH/c1-20-10-7-9(8-11(21-2)12(10)18)13(19)22-6-4-3-5-17-14(15)16;/h7-8,18H,3-6H2,1-2H3,(H4,15,16,17);1H |
| InChI Key | GHVZIMAVDJZQGP-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/139705_1_24735_18_0.pdf |
| Use of | Leonurine hydrochloride is an alkaloid isolated from Herba leonuri, with anti-oxidative and anti-inflammatory. Properties Name 4-(diaminomethylideneamino)butyl 4-hydroxy-3,5-dimethoxybenzoate,hydrochloride Synonym More Synonyms Leonurine hydrochloride Biological Activity Description Leonurine hydrochloride is an alkaloid isolated from Herba leonuri, with anti-oxidative and anti-inflammatory. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Natural Products >> Alkaloid Research Areas >> Inflammation/Immunology References [1]. Jiang T, et al. Leonurine Prevents Atherosclerosis Via Promoting the Expression of ABCA1 and ABCG1 in a Pparγ/Lxrα Signaling Pathway-Dependent Manner. Cell Physiol Biochem. 2017;43(4):1703-1717. [2]. Zhang L, et al. Novel hepatoprotective role of Leonurine hydrochloride against experimental non-alcoholic steatohepatitis mediated via AMPK/SREBP1 signaling pathway. Biomed Pharmacother. 2018 Dec 7;110:571-581. [3]. Hu ZC, et al. Inhibition of PI3K/Akt/NF-κB signaling with leonurine for ameliorating the progression of osteoarthritis: In vitro and in vivo studies. J Cell Physiol. 2018 Nov 11. Chemical & Physical Properties Exact Mass 347.124786 PSA 126.89000 LogP 2.82240 InChIKey GHVZIMAVDJZQGP-UHFFFAOYSA-N Safety Information HS Code 2925290090 |
| Tax Rebate | 9.0% |
| Supervision | none |
| Transport Info | Product name: Summary 2925290090 other imines and their derivatives; salts thereof. Supervision conditions:None. VAT: 17.0%. Tax rebate rate:9.0%. MFN tariff: 6.5%. General tariff:30.0% |
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