CAS Number12125-02-9
SynonymsAmmonium chloride; ammonia chloride; amine hydrochloride; Ammonium Chlorid; threo-amine hydrochloride; EINECS 235-186-4; ammonium cloride; MFCD00011420
Molecular FormulaNH4Cl
Molecular Weight53.49
Purity≥99.5%
Density1.52
Boiling Point100 °C750 mm Hg
Melting Point340 °C (subl.) (lit.)
Appearancepowder, crystals or chunks
EINECS235-186-4
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 12125-02-9 |
| Catalog No. | 2A-9013679 |
| Chinese Name | 氯化铵 |
| Synonyms | Ammonium chloride; ammonia chloride; amine hydrochloride; Ammonium Chlorid; threo-amine hydrochloride; EINECS 235-186-4; ammonium cloride; MFCD00011420 |
| Molecular Formula | NH4Cl |
| Molecular Weight | 53.49 |
| Purity | ≥99.5 |
| Density | 1.52 |
| Boiling Point | 100 °C750 mm Hg |
| Melting Point | 340 °C (subl.) (lit.) |
| Appearance | powder, crystals or chunks |
| Water Solubility | soluble |
| Storage Condition | 1. Store in a cool, ventilated, dry and clean ware |
| Packaging | Ⅰ |
| Application | Ammonium chloride, as a heteropolar compound that regulates pH, can cause intracellular alkalization and metabolic acidosis, thereby affecting enzyme activity and affecting the processes of biological |
| EINECS | 235-186-4 |
| HTC | 2827101000 |
| UN(IATA) | UN 无资料 |
| PubChem ID | 329752144 |
| MDL Number | MFCD00011420 |
| SMILES | N.Cl |
| InChI | 1S/ClH.H3N/h1H;1H3 |
| InChI Key | NLXLAEXVIDQMFP-UHFFFAOYSA-N |
| Beilstein/REAXYS | 4371014 |
| NACRES Code | NA.21 |
| eCl@ss | 38050207 |
| UNSPSC | 12352300 |
| MSDS | msds/13679_1_12125_02_9.pdf |
| Bioactivity | Ammonium chloride, as a heteropolar compound with pH value regulation, can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system. Ammonium chloride is an autophagy inhibitor[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy In Vitro Ammonium chloride (NH4Cl), a lysosomotropic agent that raises intralysosomal pH, reduces the yield of reovirus during infection of mouse L cells[2]. In Vivo Ammonium chloride (0.28 M in drinking water) promotes the survival of myocardial cells in vivo by decreasing contractile dysfunction, cardiac hypertrophy, inflammation, apoptosis and autophagy[1]. Animal Model: 8-9-week-old C57B/L6 mice[1] Dosage: 0.28 M in drinking water (5 mg/kg doxorubicin once a week for 2 weeks) Administration: 0.28 M in drinking water (5 mg/kg doxorubicin once a week for 2 weeks) Result: Effectively improved doxorubicin (DOX)-induced cardiomyocyte apoptosis and cardiac dysfunction in mice. References [1]. Huang X, et al. NH4Cl treatment prevents doxorubicin-induced myocardial dysfunction in vivo. Life Sci. 2019;227:94-100. [2]. Canning WM, Fields BN. Ammonium chloride prevents lytic growth of reovirus and helps to establish persistent infection in mouse L cells. Science. 1983;219(4587):987-988. Chemical & Physical Properties Density 1.52 Boiling Point 100 °C750 mm Hg Melting Point 340 °C (subl.)(lit.) Molecular Formula ClH4N Molecular Weight 53.49150 Exact Mass 53.00320 LogP 1.17820 Vapour density 1.9 (vs air) Vapour Pressure 1 mm Hg ( 160.4 °C) Index of Refraction 1.642 InChIKey NLXLAEXVIDQMFP-UHFFFAOYSA-N SMILES [Cl-].[NH4+] Stability Stable. Incompatible with strong acids, strong bases. Water Solubility soluble |
| Use of | Ammonium chloride, as a heteropolar compound with pH value regulation, can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system. Ammonium chloride is an autophagy inhibitor[1][2]. Properties Articles461 Name ammonium chloride Synonym More Synonyms Ammonium Chloride Biological Activity Description Ammonium chloride, as a heteropolar compound with pH value regulation, can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system. Ammonium chloride is an autophagy inhibitor[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy References [2]. Canning WM, Fields BN. Ammonium chloride prevents lytic growth of reovirus and helps to establish persistent infection in mouse L cells. Science. 1983;219(4587):987-988. Chemical & Physical Properties Molecular Formula ClH4N Exact Mass 53.00320 LogP 1.17820 Vapour density 1.9 (vs air) Index of Refraction 1.642 InChIKey NLXLAEXVIDQMFP-UHFFFAOYSA-N SMILES [Cl-].[NH4+] Stability Stable. Incompatible with strong acids, strong bases. Water Solubility soluble |
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