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Home > Products > Pharmaceuticals & Life Science > Pharmaceutical Intermediates > 4-AMINO-1-((2R,4S,5R)-4-HYDROXY-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL)-5-(HYDROXYMETHYL)PYRIMIDIN-2(1H)-ONE
4-AMINO-1-((2R,4S,5R)-4-HYDROXY-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL)-5-(HYDROXYMETHYL)PYRIMIDIN-2(1H)-ONE structure, CAS 7226-77-9

4-AMINO-1-((2R,4S,5R)-4-HYDROXY-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL)-5-(HYDROXYMETHYL)PYRIMIDIN-2(1H)-ONE

CAS Number7226-77-9

Synonyms5-hydroxymethyl-2,4-dimethyl-pyrrole-3-carboxylic acid ethyl ester; 5-(Hydroxymethyl)-2'-deoxycytidine; 5-Hydroxymethyl-2,4-dimethyl-pyrrol-3-carbonsaeure-aethylester; 5-Hydroxymethyl-2,4-dimethyl-3-pyrrolcarbonsaeure-ethylester

Molecular FormulaC10H15O5N3

Molecular Weight257.25

Purity96+%

Density

Boiling Point

Melting Point205 °C

Flash Point

AppearanceSolid;White to Light yellow powder to crystal

EINECS0

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-0136501 Purity: 96+%
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Quality Control of [ 7226-77-9 ] Purity: 96+% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number7226-77-9
Catalog No.2A-0136501
Chinese Name5-(羟甲基)-2'-脱氧胞苷
Synonyms5-hydroxymethyl-2,4-dimethyl-pyrrole-3-carboxylic acid ethyl ester; 5-(Hydroxymethyl)-2'-deoxycytidine; 5-Hydroxymethyl-2,4-dimethyl-pyrrol-3-carbonsaeure-aethylester; 5-Hydroxymethyl-2,4-dimethyl-3-pyrrolcarbonsaeure-ethylester
Molecular FormulaC10H15O5N3
Molecular Weight257.25
Purity96+
Melting Point205 °C
AppearanceSolid;White to Light yellow powder to crystal
Storage Conditionroom temperature, dry
Application5-Hydroxymethyl-2'-deoxycytidine (5hmdC) is the oxidized derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA. 5-Hydroxymethyl-2'-deoxycytidine may serve as a marker of irreversible cellular damage.
EINECS0
HTC0
UN(IATA)0
MDL NumberMFCD09842113
SMILESNc1nc(=O)n(C2CC(O)C(CO)O2)cc1CO
InChIInChI=1S/C10H15N3O5/c11-9-5(3-14)2-13(10(17)12-9)8-1-6(16)7(4-15)18-8/h2,6-8,14-16H,1,3-4H2,(H2,11,12,17)/t6-,7+,8+/m0/s1
InChI KeyHMUOMFLFUUHUPE-XLPZGREQSA-N
MSDSmsds/136501_1_7226_77_9.pdf
Bioactivity5-Hydroxymethyl-2'-deoxycytidine (5hmdC) is an oxidation derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA. 5-Hydroxymethyl-2'-deoxycytidine may serve as a marker of irreversibly damaged cells[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others References [1]. Ewelina Zarakowska, et al. Oxidation Products of 5-Methylcytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice. J Gerontol A Biol Sci Med Sci. 2018 Jul 9;73(8):1003-1009. [2]. Shuo Liu, et al. Quantitative assessment of Tet-induced oxidation products of 5-methylcytosine in cellular and tissue DNA. Nucleic Acids Res. 2013 Jul;41(13):6421-9. Chemical & Physical Properties Melting Point 205 °C Molecular Formula C10H16N3O8P Molecular Weight 337.22300 Exact Mass 337.06800 PSA 187.17000 InChIKey HMUOMFLFUUHUPE-XLPZGREQSA-N SMILES Nc1nc(=O)n(C2CC(O)C(CO)O2)cc1CO
Use of5-Hydroxymethyl-2'-deoxycytidine (5hmdC) is an oxidation derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA. 5-Hydroxymethyl-2'-deoxycytidine may serve as a marker of irreversibly damaged cells[1][2]. Properties Name 5-(Hydroxymethyl)-2'-deoxycytidine Synonym More Synonyms 5-Hydroxymethyl-2'-deoxycytidine Biological Activity Description 5-Hydroxymethyl-2'-deoxycytidine (5hmdC) is an oxidation derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA. 5-Hydroxymethyl-2'-deoxycytidine may serve as a marker of irreversibly damaged cells[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others References [1]. Ewelina Zarakowska, et al. Oxidation Products of 5-Methylcytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice. J Gerontol A Biol Sci Med Sci. 2018 Jul 9;73(8):1003-1009. [2]. Shuo Liu, et al. Quantitative assessment of Tet-induced oxidation products of 5-methylcytosine in cellular and tissue DNA. Nucleic Acids Res. 2013 Jul;41(13):6421-9. Chemical & Physical Properties Molecular Formula C10H16N3O8P Exact Mass 337.06800 PSA 187.17000 InChIKey HMUOMFLFUUHUPE-XLPZGREQSA-N
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified
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