![4-(8-METHYL-9H-[1,3]DIOXOLO[4',5':4,5]BENZO[1,2-D][1,2]DIAZEPIN-5-YL)ANILINE HYDROCHLORIDE structure, CAS 192065-56-8](/structures/150000/135495_1_192065_56_8.png)
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 192065-56-8 |
| Catalog No. | 2A-0135495 |
| Chinese Name | AMPA受体选择性阻断剂前体 |
| Synonyms | 1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride |
| Molecular Formula | C17H16ClN3O2 |
| Molecular Weight | 329.78 |
| Purity | ≥98 (HPLC) |
| Appearance | solid |
| Storage Condition | room temperature |
| Application | GYKI 52466 hydrochloride is an orally active, highly selective and noncompetitive AMPA/Kainate receptor antagonist with IC50 values of 7.5 and 11 μM, respectively. GYKI 52466 hydrochloride has good |
| EINECS | 0 |
| HTC | 2934999090 |
| UN(IATA) | 0 |
| PubChem ID | 24277984 |
| MDL Number | MFCD00153803 |
| SMILES | Cl[H].CC1=NN=C(c2ccc(N)cc2)c3cc4OCOc4cc3C1 |
| InChI | 1S/C17H15N3O2.ClH/c1-10-6-12-7-15-16(22-9-21-15)8-14(12)17(20-19-10)11-2-4-13(18)5-3-11;/h2-5,7-8H,6,9,18H2,1H3;1H |
| InChI Key | RUBSCPARMVJNKX-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/135495_1_192065_56_8.pdf |
| Use of | GYKI 52466 hydrochloride is an orally active, highly selective and noncompetitive AMPA/kainate receptor antagonist with the IC50 values of 7.5 and 11μM, respectively. GYKI 52466 hydrochloride has good blood brain barrier permeability and anticonvulsant effect. GYKI 52466 hydrochloride can be used in Parkinson's disease research[1][2]. Properties Name 4-(8-methyl-9H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl)aniline,hydrochloride Synonym More Synonyms Biological Activity Description GYKI 52466 hydrochloride is an orally active, highly selective and noncompetitive AMPA/kainate receptor antagonist with the IC50 values of 7.5 and 11μM, respectively. GYKI 52466 hydrochloride has good blood brain barrier permeability and anticonvulsant effect. GYKI 52466 hydrochloride can be used in Parkinson's disease research[1][2]. Related Catalog Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR In Vitro GYKI 52466 hydrochloride (0.3-100 μM) inhibits inward currents activated by AMPA and Kainate receptor in cultured rat hippocampal neurons[1]. References [1]. S D Donevan, et al. GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses. Neuron. 1993 Jan;10(1):51-9. [2]. A G Chapman, et al. The anticonvulsant effect of the non-NMDA antagonists, NBQX and GYKI 52466, in mice. Epilepsy Res. 1991 Jul;9(2):92-6. Chemical & Physical Properties Exact Mass 329.09300 PSA 69.20000 LogP 3.02130 InChIKey RUBSCPARMVJNKX-UHFFFAOYSA-N Safety Information Signal Word Warning Hazard Statements H315-H319-H335 Precautionary Statements P261-P305 + P351 + P338 Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves Hazard Codes Xn Safety Phrases 22-26-36 RIDADR NONH for all modes of transport HS Code 2934999090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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