| Chemical & Physical Properties | |
|---|---|
| CAS Number | 176977-56-3 |
| Catalog No. | 2A-0135481 |
| Chinese Name | 4-[6-甲氧基-2-(4-甲氧基苯基)苯并呋喃-3-羰基]苄腈 |
| Synonyms | MFCD00945878 |
| Molecular Formula | C24H17NO4 |
| Molecular Weight | 383.40 |
| Purity | ≥98 (HPLC) |
| Density | 1.31g/cm3 |
| Boiling Point | 617.2ºC at 760mmHg |
| Appearance | powder |
| Storage Condition | 2-8°C |
| Application | LY320135 is a potent and selective CB1 receptor antagonist with a Ki of 141 nM. LY320135 also binds to 5-HT2 and muscarinic receptors with Ki values of 6.4 μM and 2.1 μM, respectively. LY320135 has |
| EINECS | 0 |
| HTC | 2932999099 |
| UN(IATA) | 0 |
| PubChem ID | 329817622 |
| MDL Number | MFCD00945878 |
| SMILES | COc1ccc(cc1)-c2oc3cc(OC)ccc3c2C(=O)c4ccc(cc4)C#N |
| InChI | 1S/C24H17NO4/c1-27-18-9-7-17(8-10-18)24-22(20-12-11-19(28-2)13-21(20)29-24)23(26)16-5-3-15(14-25)4-6-16/h3-13H,1-2H3 |
| InChI Key | RYNSGDFWBJWWSZ-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/135481_1_176977_56_3.pdf |
| Use of | LY320135 is a potent and selective antagonist of CB1 receptor, with a Ki of 141 nM. LY320135 also binds to 5-HT2 and muscarinic receptors with Kis of 6.4 μM and 2.1 μM, respectively. LY320135 exhibits neuroprotective effect[1][2]. Properties Name 4-[6-methoxy-2-(4-methoxyphenyl)-1-benzofuran-3-carbonyl]benzonitrile Synonym More Synonyms LY320135 Biological Activity Description LY320135 is a potent and selective antagonist of CB1 receptor, with a Ki of 141 nM. LY320135 also binds to 5-HT2 and muscarinic receptors with Kis of 6.4 μM and 2.1 μM, respectively. LY320135 exhibits neuroprotective effect[1][2]. Related Catalog Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor CB1:141 nM (Ki) 5-HT2 Receptor:6.4 μM (Ki) muscarinic receptor:2.1 μM (Ki) CB2:>10 μM (Ki) References [1]. Felder CC, et, al. LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation. J Pharmacol Exp Ther. 1998 Jan; 284(1):291-7. [2]. Landucci E, et, al. CB1 receptors and post-ischemic brain damage: studies on the toxic and neuroprotective effects of cannabinoids in rat organotypic hippocampal slices. Neuropharmacology. 2011 Mar; 60(4):674-82. Chemical & Physical Properties Molecular Formula C24H17NO4 Exact Mass 383.11600 PSA 72.46000 LogP 5.21968 Index of Refraction 1.664 InChIKey RYNSGDFWBJWWSZ-UHFFFAOYSA-N Safety Information Signal Word Danger Hazard Statements H301 Precautionary Statements P301 + P310 HS Code 2932999099 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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