CAS Number504-24-5
Synonymspyridin-4-amine; T6NJ DZ; Neurelan; p-amino pyridine; Ampydin; 4APY; 4-Aminopyridine; EINECS 207-987-9; p-Aminopyridine [UN2671] [Poison]; Ampyra; 4-pyridylamine; 5-22-09-00106 (Beilstein Handbook Reference); Dalfampridine; EL 970; vmi10-3; Prc 1237; Pyridin-4-amin; Fampridine; 4-pyridinylamine; 4-AP; mi-w-3; Pymadin; avitrol; pyridin-4-yl-amine; MFCD00006439; 4-Pyridinamine; pyridine-4-amine; 4-amino-pyridine; 4-AMINO PYRIDINE
Molecular FormulaC5H6N2
Molecular Weight94.11
Purity98%
Density1.1±0.1 g/cm3
Boiling Point273 °C (lit.)
Melting Point155-158 °C (lit.)
Appearancecrystals
EINECS207-987-9
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 504-24-5 |
| Catalog No. | 2A-9013482 |
| Chinese Name | 4-氨基吡啶 |
| Synonyms | pyridin-4-amine; T6NJ DZ; Neurelan; p-amino pyridine; Ampydin; 4APY; 4-Aminopyridine; EINECS 207-987-9; p-Aminopyridine [UN2671] [Poison]; Ampyra; 4-pyridylamine; 5-22-09-00106 (Beilstein Handbook Reference); Dalfampridine; EL 970; vmi10-3; Prc 1237; Pyridin-4-amin; Fampridine; 4-pyridinylamine; 4-AP; mi-w-3; Pymadin; avitrol; pyridin-4-yl-amine; MFCD00006439; 4-Pyridinamine; pyridine-4-amine; 4-amino-pyridine; 4-AMINO PYRIDINE |
| Molecular Formula | C5H6N2 |
| Molecular Weight | 94.11 |
| Purity | 98 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 273 °C (lit.) |
| Melting Point | 155-158 °C (lit.) |
| Appearance | crystals |
| Storage Condition | Storage precautions: Store in a cool, well-ventila |
| Packaging | II |
| Application | 4-Aminopyridine is a non-selective potassium channel blocker that can bind to the target from the cytoplasmic side. |
| EINECS | 207-987-9 |
| HTC | 2933399090 |
| PubChem ID | 24891285 |
| MDL Number | MFCD00006439 |
| SMILES | Nc1ccncc1 |
| InChI | 1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7) |
| InChI Key | NUKYPUAOHBNCPY-UHFFFAOYSA-N |
| Beilstein/REAXYS | 105782 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | 6.1 |
| MSDS | msds/13482_1_504_24_5.pdf |
| Bioactivity | 4-Aminopyridine is a nonselective K+ channel blocker that binds from the cytoplasmic side of the cell membrane.Target: Potassium Channel4-Aminopyridine(4AP) is a nonselective K+ channel blocker that binds from the cytoplasmic side of the cell membrane. 4AP strongly potentiates transmitter release from the unmyelinated terminals of rat motor nerves, and the possibility arose that demyelinated axon membrane, which can conduct impulses continuously like an unmyelinated fibre, might further resemble its unmyelinated terminals by responding to 4AP. In testing this hypothesis [1]. 4-AP blocked channels from the cytosolic face. 4-AP can both enhance and block Kv1.5 current and suggest that 4-AP can bind with different affinities to more than one site on Kv1.5 channels [2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Others References [1]. Sherratt, R.M., H. Bostock, and T.A. Sears, Effects of 4-aminopyridine on normal and demyelinated mammalian nerve fibres. Nature, 1980. 283(5747): p. 570-2. [2]. Bouchard, R. and D. Fedida, Closed- and open-state binding of 4-aminopyridine to the cloned human potassium channel Kv1.5. J Pharmacol Exp Ther, 1995. 275(2): p. 864-76. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 192.7±40.0 °C at 760 mmHg Melting Point 157 °C Molecular Formula C5H6N2 Molecular Weight 94.115 Flash Point 70.3±27.3 °C Exact Mass 94.053101 PSA 38.91000 LogP -2.24 Vapour Pressure 0.5±0.4 mmHg at 25°C Index of Refraction 1.569 InChIKey NUKYPUAOHBNCPY-UHFFFAOYSA-N SMILES Nc1ccncc1 |
| Use of | Properties Articles115 Name 4-aminopyridine Synonym More Synonyms 4-AMINOPYRIDINE Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Others References [1]. Sherratt, R.M., H. Bostock, and T.A. Sears, Effects of 4-aminopyridine on normal and demyelinated mammalian nerve fibres. Nature, 1980. 283(5747): p. 570-2. [2]. Bouchard, R. and D. Fedida, Closed- and open-state binding of 4-aminopyridine to the cloned human potassium channel Kv1.5. J Pharmacol Exp Ther, 1995. 275(2): p. 864-76. Chemical & Physical Properties Molecular Formula C5H6N2 Exact Mass 94.053101 PSA 38.91000 LogP -2.24 Index of Refraction 1.569 InChIKey NUKYPUAOHBNCPY-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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