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Home > Products > Pharmaceutical R&D Materials > Heterocyclic Building Blocks > 4-(2-((4-(2-(PYRIDIN-2-YL)-5,6-DIHYDRO-4H-PYRROLO[1,2-B]PYRAZOL-3-YL)QUINOLIN-7-YL)OXY)ETHYL)MORPHOLINE
4-(2-((4-(2-(PYRIDIN-2-YL)-5,6-DIHYDRO-4H-PYRROLO[1,2-B]PYRAZOL-3-YL)QUINOLIN-7-YL)OXY)ETHYL)MORPHOLINE structure, CAS 700874-71-1

4-(2-((4-(2-(PYRIDIN-2-YL)-5,6-DIHYDRO-4H-PYRROLO[1,2-B]PYRAZOL-3-YL)QUINOLIN-7-YL)OXY)ETHYL)MORPHOLINE

CAS Number700874-71-1

Synonyms7-(2-morpholin-4-yl-ethoxy)-4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-quinoline; cc-120; 7-[2-(morpholin-4-yl)ethoxy]-4-[2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline; 7-[2-(4-Morpholinyl)ethoxy]-4-[2-(2-pyridinyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline; Dihydropyrrolopyrazole,15d

Molecular FormulaC26H27N5O2

Molecular Weight441.52

Purity≥98 (HPLC)%

Density1.3±0.1 g/cm3

Boiling Point640.9±55.0 °C at 760 mmHg

Melting Point

Flash Point

Appearancepowder

EINECS0

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-0134262 Purity: ≥98 (HPLC)%
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Quality Control of [ 700874-71-1 ] Purity: ≥98 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number700874-71-1
Catalog No.2A-0134262
Chinese Name4-[5,6-二氢-2-(2-吡啶)-4H-吡咯并[1,2-b]吡唑-3-基]-7-[2-(4-吗啉)乙氧基]喹啉
Synonyms7-(2-morpholin-4-yl-ethoxy)-4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-quinoline; cc-120; 7-[2-(morpholin-4-yl)ethoxy]-4-[2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline; 7-[2-(4-Morpholinyl)ethoxy]-4-[2-(2-pyridinyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline; Dihydropyrrolopyrazole,15d
Molecular FormulaC26H27N5O2
Molecular Weight441.52
Purity≥98 (HPLC)
Density1.3±0.1 g/cm3
Boiling Point640.9±55.0 °C at 760 mmHg
Appearancepowder
Storage Condition-20°C
ApplicationLY2109761 is an orally available, selective TGF-β receptor type I/II inhibitor with Ki of 38 nM and 300 nM respectively.
EINECS0
HTC2934999090
UN(IATA)0
MDL NumberMFCD12923354
SMILES[n]21nc(c(c2CCC1)c4c5c(ncc4)cc(cc5)OCCN6CCOCC6)c3ncccc3
InChI1S/C26H27N5O2/c1-2-9-27-22(4-1)26-25(24-5-3-11-31(24)29-26)21-8-10-28-23-18-19(6-7-20(21)23)33-17-14-30-12-15-32-16-13-30/h1-2,4,6-10,18H,3,5,11-17H2
InChI KeyIHLVSLOZUHKNMQ-UHFFFAOYSA-N
NACRES CodeNA.21
UNSPSC12352200
MSDSmsds/134262_1_700874_71_1.pdf
Use ofLY2109761 is an orally active, selective TGF-β receptor type I/II inhibitor with Kis of 38 nM and 300 nM, respectively. Properties Name 4-[2-[4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl]oxyethyl]morpholine Synonym More Synonyms LY2109761 Biological Activity Description LY2109761 is an orally active, selective TGF-β receptor type I/II inhibitor with Kis of 38 nM and 300 nM, respectively. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> TGF-beta/Smad >> TGF-β Receptor Research Areas >> Cancer Ki: 38 nM (TβRI), 300 nM (TβRII) References [1]. Melisi D, et al. LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. Mol Cancer Ther, 2008, 7(4), 829-840. [2]. Fransvea E, et al. Blocking transforming growth factor-beta up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells. Hepatology, 2008, 47(5), 1557-1566. [3]. Zhang M, et al. Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma. Cancer Res, 2011, 71(23), 7155-7167. Chemical & Physical Properties Molecular Formula C26H27N5O2 Exact Mass 441.216461 PSA 65.30000 Index of Refraction 1.700 Safety Information HS Code 2934999090 Synthetic Route Total: 1 Page morpholine CAS#:110-91-8 methanesulfonic... CAS#:700874-75-5 CAS#:700874-71-1 Precursor & DownStream Precursor 2 CAS#:110-91-8 morpholine CAS#:700874-75-5 methanesulfonic... DownStream 0
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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