CAS Number136647-02-4
Synonyms4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochloride; 4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine monohydrochloride
Molecular FormulaC29H36ClNO2
Molecular Weight466.05
Purity≥98 (HPLC)%
Appearancesolid
EINECS0
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 136647-02-4 |
| Catalog No. | 2A-0134005 |
| Chinese Name | 4-(苯甲酰氧基甲基)-1-[3-(4-甲氧基苯基)丙基]哌啶; 盐酸盐 |
| Synonyms | 4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochloride; 4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine monohydrochloride |
| Molecular Formula | C29H36ClNO2 |
| Molecular Weight | 466.05 |
| Purity | ≥98 (HPLC) |
| Appearance | solid |
| Storage Condition | -20°C |
| Application | UK-78282 hydrochloride, a novel piperidine, is a potent and selective Kv1.3 blocker with an IC50 of 200 nM. UK-78,282 effectively inhibits human T lymphocyte activation in vitro. UK-78282 hydrochlorid |
| EINECS | 0 |
| HTC | 2933399090 |
| UN(IATA) | 0 |
| PubChem ID | 329827628 |
| MDL Number | MFCD16875438 |
| SMILES | Cl.COc1ccc(CCCN2CCC(CC2)COC(c3ccccc3)c4ccccc4)cc1 |
| InChI | 1S/C29H35NO2.ClH/c1-31-28-16-14-24(15-17-28)9-8-20-30-21-18-25(19-22-30)23-32-29(26-10-4-2-5-11-26)27-12-6-3-7-13-27;/h2-7,10-17,25,29H,8-9,18-23H2,1H3;1H |
| InChI Key | ZZSQARULZYQMIG-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | transportation |
| MSDS | msds/134005_1_136647_02_4.pdf |
| Bioactivity | UK-78282, a novel piperidine, potent and selective Kv1.3 blocker with an IC50 of 200 nM. UK-78,282 effectively suppresses human T-lymphocyte activation in vitro. UK-78,282 binds to residues at the inner surface of the channel overlapping the site of action of verapamil[1]. Related Catalog Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Target IC50: 200 nM (Kv1.3)[1] References [1]. D C Hanson, et al. UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br J Pharmacol. 1999 Apr;126(8):1707-16 Chemical & Physical Properties Molecular Formula C29H36ClNO2 Molecular Weight 466.05 Exact Mass 465.24300 PSA 21.70000 LogP 6.88590 InChIKey ZZSQARULZYQMIG-UHFFFAOYSA-N SMILES COc1ccc(CCCN2CCC(COC(c3ccccc3)c3ccccc3)CC2)cc1.Cl Storage condition -20°C |
| Use of | UK-78282, a novel piperidine, potent and selective Kv1.3 blocker with an IC50 of 200 nM. UK-78,282 effectively suppresses human T-lymphocyte activation in vitro. UK-78,282 binds to residues at the inner surface of the channel overlapping the site of action of verapamil[1]. Properties Name 4-(benzhydryloxymethyl)-1-[3-(4-methoxyphenyl)propyl]piperidine,hydrochloride Synonym More Synonyms UK-78282 Hydrochloride Biological Activity Description UK-78282, a novel piperidine, potent and selective Kv1.3 blocker with an IC50 of 200 nM. UK-78,282 effectively suppresses human T-lymphocyte activation in vitro. UK-78,282 binds to residues at the inner surface of the channel overlapping the site of action of verapamil[1]. Related Catalog Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel IC50: 200 nM (Kv1.3)[1] References [1]. D C Hanson, et al. UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br J Pharmacol. 1999 Apr;126(8):1707-16 Chemical & Physical Properties Exact Mass 465.24300 PSA 21.70000 LogP 6.88590 InChIKey ZZSQARULZYQMIG-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Danger Regulations: 3077 International Maritime Transport Danger Regulations: 3077 International Air Transport Danger Regulations: 3077 14.2 Names specified by the United Nations (UN) European land transport hazard regulations: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (UK-78282 monohydrochloride) IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (UK-78282 monohydrochloride) International air transport hazard regulations: Environmentally hazardous substance, solid, n.o.s. (UK-78282 monohydrochloride) 14.3 Transport hazard categories European land transport Dangerous Regulations: 9 International sea transport Dangerous Regulations: 9 International air transport Dangerous Regulations: 9 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: Yes International Maritime Transport Dangerous Regulations Maritime Pollutants: Yes International Air Transport Dangerous Regulations: Yes 14.6 Special precautions for users further information Dangerous goods are individually packaged, with liquids exceeding 5 liters or solids exceeding 5 kilograms. The outer packaging of each independent package and the combined independent inner package must have EHS on it. Identification (according to European ADR Regulation 2.2.9.1.10, IMDG Regulation 2.10.3), |
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