CAS Number616-45-5
Synonyms2-Pyrrolidinone; 1-azacyclopentan-2-one; azacyclopentan-2-one; pyrrolidin-2-one; pyrrolidinone; 2-oxopyrrolidine; α-pyrrolidone; MFCD00005270; Pyrrolidin-2-on; pyrrolidone; Tetrahydropyrrolone; 2-Pyrrolidone; EINECS 210-483-1
Molecular FormulaC4H7NO
Molecular Weight85.10
Purity≥99%
Density1.103
Boiling Point245 °C (lit.)
Melting Point23-25 °C (lit.)
Appearancesolid
EINECS210-483-1
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 616-45-5 |
| Catalog No. | 2A-9013364 |
| Chinese Name | 2-吡咯烷酮 |
| Synonyms | 2-Pyrrolidinone; 1-azacyclopentan-2-one; azacyclopentan-2-one; pyrrolidin-2-one; pyrrolidinone; 2-oxopyrrolidine; α-pyrrolidone; MFCD00005270; Pyrrolidin-2-on; pyrrolidone; Tetrahydropyrrolone; 2-Pyrrolidone; EINECS 210-483-1 |
| Molecular Formula | C4H7NO |
| Molecular Weight | 85.10 |
| Purity | ≥99 |
| Density | 1.103 |
| Boiling Point | 245 °C (lit.) |
| Melting Point | 23-25 °C (lit.) |
| Appearance | solid |
| Water Solubility | miscible |
| Storage Condition | The maximum allowable concentration in the workpla |
| Packaging | III |
| Application | 2-Pyrrolidone is an active compound found in Brassica oleracea varieties and has anti-cancer properties. |
| EINECS | 210-483-1 |
| HTC | 2933790090 |
| PubChem ID | 24854414 |
| MDL Number | MFCD00005270 |
| SMILES | O=C1CCCN1 |
| InChI | 1S/C4H7NO/c6-4-2-1-3-5-4/h1-3H2,(H,5,6) |
| InChI Key | HNJBEVLQSNELDL-UHFFFAOYSA-N |
| Beilstein/REAXYS | 105241 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/13364_1_616_45_5.pdf |
| Bioactivity | 2-Pyrrolidinone is an active compound present in Brassica oleracea var. capitata and displays anticancer property. Related Catalog Research Areas >> Cancer Target Human Endogenous Metabolite In Vitro Radical scavenging activity increases with increasing the amount of 2-Pyrrolidinone. The cytotoxicity of 2-Pyrrolidinone is found to be dose and time dependent, and the effect is observed microscopically in all of the selected cancer cell lines. It is observed that 2-Pyrrolidinone has cytotoxic concentrations of 2.5 mg/mL for HeLa, 3 mg/mL for PC-3 cells at 24 h and 1.5 mg/mL for HeLa and 2 mg/mL for PC-3 cells at 48 h, respectively. The cell viability decreases with increasing concentrations of purified 2-Pyrrolidinone. After treatment with 2-Pyrrolidinone their IC50 concentrations (1.5 mg/mL and 2 mg/mL for HeLa and PC-3 cells, respectively) for a period of 24 h, morphological changes in the cells are observed. It is demonstrated that 2-Pyrrolidinone induces apoptosis in HeLa and PC-3 cells via G0/G1phase of cell cycle arrest[1]. Cell Assay The inhibitory concentrations (IC50) are evaluated using an MTT assay. Cancer cells are grown (1×104 cells/well) in a 96-well plate for 48 h into 75% confluence. The medium is replaced with fresh medium containing concentration of (0.5 to 5 mg/mL) 2-Pyrrolidinone, and the cells are further incubated for 24 h and 48 h. The culture medium is removed, and 100 mL of the MTT solution is added to each well and incubated at 37°C for 4 h. After removal of the supernatant, 50 mL of DMSO is added to each of the wells and incubated for 10 min to solubilize the formazan crystals. The optical density is measured at 620 nm in an ELISA multi-well plate reader. The OD value is used to calculate the percentage of viability[1]. References [1]. Thangam R, et al. Antioxidant and in vitro anticancer effect of 2-pyrrolidinone rich fraction of Brassica oleracea var. capitata through induction of apoptosis in human cancer cells. Phytother Res. 2013 Nov;27(11):1664-70. Chemical & Physical Properties Density 1.103 Boiling Point 250 ºC Melting Point 25.5 ºC Molecular Formula C4H7NO Molecular Weight 85.104 Flash Point 138 ºC Exact Mass 85.052765 PSA 29.10000 LogP -1.01 Vapour density 2.9 (vs air) Vapour Pressure 0.1±0.8 mmHg at 25°C Index of Refraction 1.486-1.488 InChIKey HNJBEVLQSNELDL-UHFFFAOYSA-N SMILES O=C1CCCN1 Storage condition 2-8°C Water Solubility miscible |
| Use of | 2-Pyrrolidinone is an active compound present in Brassica oleracea var. capitata and displays anticancer property. Properties Articles81 Name pyrrolidin-2-one Synonym More Synonyms 2-Pyrrolidinone Biological Activity Description 2-Pyrrolidinone is an active compound present in Brassica oleracea var. capitata and displays anticancer property. Related Catalog Research Areas >> Cancer Human Endogenous Metabolite References [1]. Thangam R, et al. Antioxidant and in vitro anticancer effect of 2-pyrrolidinone rich fraction of Brassica oleracea var. capitata through induction of apoptosis in human cancer cells. Phytother Res. 2013 Nov;27(11):1664-70. Chemical & Physical Properties Molecular Formula C4H7NO Exact Mass 85.052765 PSA 29.10000 LogP -1.01 Vapour density 2.9 (vs air) Index of Refraction 1.486-1.488 InChIKey HNJBEVLQSNELDL-UHFFFAOYSA-N Water Solubility miscible |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 9.0% Ordinary tariff: 20.0% |
| Transport Info | Product name: Chemical name |
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