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Zofenopril calcium structure, CAS 81938-43-4

Zofenopril calcium

CAS Number81938-43-4

SynonymsZOFENOPRIL CALCIUM; L-Proline, 1-[(2S)-3-(benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-, calcium salt, (4S)- (2:1); MFCD08704648; Zofenopril calcium salt

Molecular FormulaC22H22Ca0.5NO4S2

Molecular Weight448.58

Purity99%

Density1.34 g/cm3

Boiling Point646.3ºC at 760 mmHg

Melting Point>250ºC

Flash Point

AppearanceWhite or whitish crystalline powder

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Cat. No.: 2A-9012999 Purity: 99%
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Quality Control of [ 81938-43-4 ] Purity: 99% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number81938-43-4
Catalog No.2A-9012999
Chinese Name佐芬普利钙
SynonymsZOFENOPRIL CALCIUM; L-Proline, 1-[(2S)-3-(benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-, calcium salt, (4S)- (2:1); MFCD08704648; Zofenopril calcium salt
Molecular FormulaC22H22Ca0.5NO4S2
Molecular Weight448.58
Purity99
Density1.34 g/cm3
Boiling Point646.3ºC at 760 mmHg
Melting Point>250ºC
AppearanceWhite or whitish crystalline powder
Storage ConditionRefrigerator
ApplicationZofenopril Calcium (SQ26991) is an antioxidant and angiotensin-converting enzyme (ACE) inhibitor.
SMILESCC(CSC(=O)c1ccccc1)C(=O)N1CC(Sc2ccccc2)CC1C(=O)[O-].CC(CSC(=O)c1ccccc1)C(=O)N1CC(Sc2ccccc2)CC1C(=O)[O-].[Ca+2]
InChIInChI=1S/2C22H23NO4S2.Ca/c2*1-15(14-28-22(27)16-8-4-2-5-9-16)20(24)23-13-18(12-19(23)21(25)26)29-17-10-6-3-7-11-17;/h2*2-11,15,18-19H,12-14H2,1H3,(H,25,26);/q;;+2/p-2/t2*15-,18+,19+;/m11./s1
InChI KeyNSYUKKYYVFVMST-LETVYOFWSA-L
MSDSmsds/12999_2_81938_43_4.pdf
BioactivityZofenopril Calcium(SQ26991) is an antioxidant that acts as an angiotensin-converting enzyme inhibitor.Target: ACEZofenopril is a pro-drug designed to undergo metabolic hydrolysis yielding the active free sulfhydryl compound zofenoprilat, which is an angiotensin converting enzyme (ACE) inhibitor [1]. Zofenopril promotes the regeneration of peripheral nerve injuries in rat models [2]. Zofenopril increases SR calcium cycling and stimulates active calcium uptake into the SR [3]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) Research Areas >> Cardiovascular Disease References [1]. Dal Bo, L., P. Mazzucchelli, and A. Marzo, Assay of zofenopril and its active metabolite zofenoprilat by liquid chromatography coupled with tandem mass spectrometry. J Chromatogr B Biomed Sci Appl, 2000. 749(2): p. 287-94. [2]. Kalender, A.M., et al., Effect of Zofenopril on regeneration of sciatic nerve crush injury in a rat model. J Brachial Plex Peripher Nerve Inj, 2009. 4: p. 6. [3]. Frascarelli, S., et al., Effects of zofenopril on cardiac sarcoplasmic reticulum calcium handling. J Cardiovasc Pharmacol, 2009. 54(5): p. 456-63. Chemical & Physical Properties Density 1.34 g/cm3 Boiling Point 646.3ºC at 760 mmHg Melting Point >250ºC Molecular Formula C22H22Ca0.5NO4S2 Molecular Weight 448.58 Flash Point 344.7ºC PSA 228.56000 LogP 7.80660 InChIKey NSYUKKYYVFVMST-LETVYOFWSA-L SMILES CC(CSC(=O)c1ccccc1)C(=O)N1CC(Sc2ccccc2)CC1C(=O)[O-].CC(CSC(=O)c1ccccc1)C(=O)N1CC(Sc2ccccc2)CC1C(=O)[O-].[Ca+2] Storage condition Refrigerator
Use ofZofenopril Calcium(SQ26991) is an antioxidant that acts as an angiotensin-converting enzyme inhibitor.Target: ACEZofenopril is a pro-drug designed to undergo metabolic hydrolysis yielding the active free sulfhydryl compound zofenoprilat, which is an angiotensin converting enzyme (ACE) inhibitor [1]. Zofenopril promotes the regeneration of peripheral nerve injuries in rat models [2]. Zofenopril increases SR calcium cycling and stimulates active calcium uptake into the SR [3]. Properties Articles25 Name zofenopril calcium Synonym More Synonyms Zofenopril calcium Biological Activity Description Zofenopril Calcium(SQ26991) is an antioxidant that acts as an angiotensin-converting enzyme inhibitor.Target: ACEZofenopril is a pro-drug designed to undergo metabolic hydrolysis yielding the active free sulfhydryl compound zofenoprilat, which is an angiotensin converting enzyme (ACE) inhibitor [1]. Zofenopril promotes the regeneration of peripheral nerve injuries in rat models [2]. Zofenopril increases SR calcium cycling and stimulates active calcium uptake into the SR [3]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) Research Areas >> Cardiovascular Disease References [1]. Dal Bo, L., P. Mazzucchelli, and A. Marzo, Assay of zofenopril and its active metabolite zofenoprilat by liquid chromatography coupled with tandem mass spectrometry. J Chromatogr B Biomed Sci Appl, 2000. 749(2): p. 287-94. [2]. Kalender, A.M., et al., Effect of Zofenopril on regeneration of sciatic nerve crush injury in a rat model. J Brachial Plex Peripher Nerve Inj, 2009. 4: p. 6. [3]. Frascarelli, S., et al., Effects of zofenopril on cardiac sarcoplasmic reticulum calcium handling. J Cardiovasc Pharmacol, 2009. 54(5): p. 456-63. Chemical & Physical Properties PSA 228.56000 LogP 7.80660 InChIKey NSYUKKYYVFVMST-LETVYOFWSA-L Storage condition Refrigerator
Transport InfoProduct Name: Zofenopril Calcium
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