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Xantinol nicotinate structure, CAS 437-74-1

Xantinol nicotinate

CAS Number437-74-1

Synonyms7-[3-[N-(2-Hydroxyethyl)amino]-2-hydroxypropyl]theophylline nicotinate; Teonicol; Xanthinol Niacinate; Xantinol nicotinate; SK 331-A; Angioamin; Xantinol Niacinate; Complamex; EINECS 207-115-7; Xanthinolnicotinat; Sadamine; Landrina; Xanthinol nicotinate; Contamex; MFCD00058342; Xavin; Stenalgil; Complamin

Molecular FormulaC19H26O6N6

Molecular Weight434.45

Purity98%

Density

Boiling Point589.3ºC at 760 mmHg

Melting Point180-184ºC

Flash Point

AppearanceWhite crystalline powder

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9012968 Purity: 98%
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Quality Control of [ 437-74-1 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number437-74-1
Catalog No.2A-9012968
Chinese Name烟酸占替诺
Synonyms7-[3-[N-(2-Hydroxyethyl)amino]-2-hydroxypropyl]theophylline nicotinate; Teonicol; Xanthinol Niacinate; Xantinol nicotinate; SK 331-A; Angioamin; Xantinol Niacinate; Complamex; EINECS 207-115-7; Xanthinolnicotinat; Sadamine; Landrina; Xanthinol nicotinate; Contamex; MFCD00058342; Xavin; Stenalgil; Complamin
Molecular FormulaC19H26O6N6
Molecular Weight434.45
Purity98
Boiling Point589.3ºC at 760 mmHg
Melting Point180-184ºC
AppearanceWhite crystalline powder
Storage Condition-20℃
ApplicationXanthinol Nicotinate (Xanthinol Niacinate) is a vasodilator that acts directly on the smooth muscle of arterioles and capillaries. Xanthinol Nicotinate dilates blood vessels, improves hemorrheology an
HTC2933990090
MDL NumberMFCD00058342
SMILESCN(CCO)CC(O)Cn1cnc2c1c(=O)n(C)c(=O)n2C.O=C(O)c1cccnc1
InChIInChI=1S/C13H21N5O4.C6H5NO2/c1-15(4-5-19)6-9(20)7-18-8-14-11-10(18)12(21)17(3)13(22)16(11)2;8-6(9)5-2-1-3-7-4-5/h8-9,19-20H,4-7H2,1-3H3;1-4H,(H,8,9)
InChI KeyGEPMAHVDJHFBJI-UHFFFAOYSA-N
MSDSmsds/12968_1_437_74_1.pdf
BioactivityXanthinol Nicotinate (Xanthinol Niacinate), a vasodilator, can act directly on the smooth muscle of small arteries and capillaries. Xanthinol Nicotinate expands blood vessels, improves blood rheology and reduces peripheral vascular resistance[1][2]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others In Vitro Xanthinol Nicotinate (Xanthinol Niacinate; 2.76-276 µM; for 24 hours) inhibits HUASMC proliferation in a dose-dependent manner[2]. Xanthinol Nicotinate (2.76-276 µM; for 24 hours) dose-dependently decreases the PDGFR mRNA and PDGFR-β levels on the cell membranes of HUASMCs[2]. Cell Proliferation Assay[2] Cell Line: human umbilical artery smooth muscle cell (HUASMC) Concentration: 2.76, 27.6 or 276 µM Incubation Time: for 24 hours Result: Inhibited HUASMC proliferation in a dose-dependent manner. Western Blot Analysis[2] Cell Line: HUASMC Concentration: 2.76, 27.6 or 276 µM Incubation Time: for 24 hours Result: Dose-dependently decreased the PDGFR mRNA and PDGFR-β levels on the cell membranes of HUASMCs. In Vivo Xanthinol Nicotinate (Xanthinol Niacinate; 75 mg/kg; IP) rapidly and transiently modifies tumor pO2 and the maximal pO2 values are obtained 10 to 30 minutes after Xanthinol Nicotinate administration[1]. Xanthinol Nicotinate is able to radiosensitize the tumors when applying 10 Gy of X-Rays during the reoxygenation of the tumors (enhancement in radiation response of 1.4)[1]. Animal Model: 5 week-old male NMRI mice[1] Dosage: 75 mg/kg Administration: IP Result: Rapidly and transiently modified tumor pO2 and Maximal pO2 values were obtained 10 to 30 minutes after XN administration. References [1]. Segers J, et al. Use of Xanthinol Nicotinate as a co-treatment for radio- and chemo-therapy in experimental tumors. Int J Cancer. 2010 Jan 15;126(2):583-8. [2]. Bai X, et al. Inhibited proliferation of human umbilical artery smooth muscle cells by xanthinol nicotinate. Med Biol Eng Comput. 2016 Jun;54(6):891-8. Chemical & Physical Properties Boiling Point 589.3ºC at 760 mmHg Melting Point 180-184ºC Molecular Formula C19H26N6O6 Molecular Weight 434.446 Flash Point 310.2ºC Exact Mass 434.191376 PSA 155.71000 Vapour Pressure 9.89E-15mmHg at 25°C InChIKey GEPMAHVDJHFBJI-UHFFFAOYSA-N SMILES CN(CCO)CC(O)Cn1cnc2c1c(=O)n(C)c(=O)n2C.O=C(O)c1cccnc1 Storage condition -20℃
Use ofXanthinol Nicotinate (Xanthinol Niacinate), a vasodilator, can act directly on the smooth muscle of small arteries and capillaries. Xanthinol Nicotinate expands blood vessels, improves blood rheology and reduces peripheral vascular resistance[1][2]. Properties Name 7-[2-hydroxy-3-[2-hydroxyethyl(methyl)amino]propyl]-1,3-dimethylpurine-2,6-dione,pyridine-3-carboxylic acid Synonym More Synonyms Xanthinol Nicotinate Biological Activity Description Xanthinol Nicotinate (Xanthinol Niacinate), a vasodilator, can act directly on the smooth muscle of small arteries and capillaries. Xanthinol Nicotinate expands blood vessels, improves blood rheology and reduces peripheral vascular resistance[1][2]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others In Vitro Xanthinol Nicotinate (Xanthinol Niacinate; 2.76-276 µM; for 24 hours) inhibits HUASMC proliferation in a dose-dependent manner[2]. Xanthinol Nicotinate (2.76-276 µM; for 24 hours) dose-dependently decreases the PDGFR mRNA and PDGFR-β levels on the cell membranes of HUASMCs[2]. Cell Proliferation Assay[2] Cell Line: human umbilical artery smooth muscle cell (HUASMC) Concentration: 2.76, 27.6 or 276 µM Incubation Time: for 24 hours Result: Inhibited HUASMC proliferation in a dose-dependent manner. Western Blot Analysis[2] Cell Line: HUASMC Concentration: 2.76, 27.6 or 276 µM Incubation Time: for 24 hours Result: Dose-dependently decreased the PDGFR mRNA and PDGFR-β levels on the cell membranes of HUASMCs. References [1]. Segers J, et al. Use of Xanthinol Nicotinate as a co-treatment for radio- and chemo-therapy in experimental tumors. Int J Cancer. 2010 Jan 15;126(2):583-8. [2]. Bai X, et al. Inhibited proliferation of human umbilical artery smooth muscle cells by xanthinol nicotinate. Med Biol Eng Comput. 2016 Jun;54(6):891-8. Chemical & Physical Properties Molecular Formula C19H26N6O6 Exact Mass 434.191376 PSA 155.71000 InChIKey GEPMAHVDJHFBJI-UHFFFAOYSA-N Storage condition -20℃
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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