CAS Number82-57-5
SynonymsVisnagidin; Visnagin; 5-methoxy-2-methylfuranobenzopyran-4-one; EINECS 201-430-3; Visnacorin; Desmethoxykhellin; MFCD00005008; Visnagine; 5-Methoxy-2-methylfuranochromone; 4-Methoxy-7-methyl-5H-furo[3,2-g][1]benzopyran-5-one; 4-Methoxy-7-methyl-5H-furo[3,2-g]chromen-5-one
Molecular FormulaC13H10O4
Molecular Weight230.22
Purity97%
Density1.3±0.1 g/cm3
Boiling Point378.2±42.0 °C at 760 mmHg
Melting Point139-142 °C
AppearanceBeige fine crystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 82-57-5 |
| Catalog No. | 2A-9012945 |
| Chinese Name | 齿阿米素; 甲氧呋豆素 |
| Synonyms | Visnagidin; Visnagin; 5-methoxy-2-methylfuranobenzopyran-4-one; EINECS 201-430-3; Visnacorin; Desmethoxykhellin; MFCD00005008; Visnagine; 5-Methoxy-2-methylfuranochromone; 4-Methoxy-7-methyl-5H-furo[3,2-g][1]benzopyran-5-one; 4-Methoxy-7-methyl-5H-furo[3,2-g]chromen-5-one |
| Molecular Formula | C13H10O4 |
| Molecular Weight | 230.22 |
| Purity | 97 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 378.2±42.0 °C at 760 mmHg |
| Melting Point | 139-142 °C |
| Appearance | Beige fine crystalline powder |
| Storage Condition | Store sealed and away from light. |
| Application | Visnagin is an antioxidant furanocoumarin derivative with anti-inflammatory and analgesic effects. Visnagin has great potential in preventing ceruloplasmin-induced acute pancreatitis (AP). Visnagin ha |
| MDL Number | MFCD00005008 |
| SMILES | COc1c2ccoc2cc2oc(C)cc(=O)c12 |
| InChI | InChI=1S/C13H10O4/c1-7-5-9(14)12-11(17-7)6-10-8(3-4-16-10)13(12)15-2/h3-6H,1-2H3 |
| InChI Key | NZVQLVGOZRELTG-UHFFFAOYSA-N |
| Hazard Symbols | Transport |
| MSDS | msds/12945_1_82_57_5.pdf |
| Bioactivity | Visnagin, an antioxidant furanocoumarin derivative, possess anti-inflammatory and analgesic properties. Visnagin has substantial potential to prevent Cerulein induced acute pancreatitis (AP). Visnagin possess promising vasodilator effects in vascular smooth muscles[1][2]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease In Vitro Visnagin (10 µM; for 4, 8, 16, 24 h) induces CYP1A1 transcription in HepG2 cells[1]. Visnagin (10 µM; for 16 h) elevates CYP1B1 gene expression in an aryl hydrocarbon receptor (AHR)-dependent manner, whereas MNF (3'-methoxy-4'-nitroflavone; 20 µM; pre-treated for 1 h) successfully counteracted this induction. Visnagin also enhances PAI-2 transcription in an AHR-dependent manner[1]. In Vivo Visnagin (10, 30, 60 mg/kg; ip; for 7 days) is effective in reducing plasma amylase and lipase levels and reduces Cerulein (50 μg/kg, six, hourly i.p. injections) induced oxidative stress in male Swiss albino mice (age: 6-8 weeks, weighing 20-25 g)[1]. Visnagin dose dependently decreases the expression of IL-1β, IL-6, TNF-α and IL-17. It attenuates the levels of nuclear p65-NFκB. Visnagin improves the antioxidant defence by improving Nrf2 expression and halts pancreatic inflammation by suppressing NFκB and nitrotyrosine expression in the acinar cells[1]. References [1]. Radim Vrzal, et al. Khellin and visnagin differentially modulate AHR signaling and downstream CYP1A activity in human liver cells. PLoS One. 2013 Sep 19;8(9):e74917. [2]. Lakshmi Priya Pasari, et al. Visnagin attenuates acute pancreatitis via Nrf2/NFκB pathway and abrogates associated multiple organ dysfunction. Biomed Pharmacother. 2019 Apr;112:108629. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 378.2±42.0 °C at 760 mmHg Melting Point 139-142 °C Molecular Formula C13H10O4 Molecular Weight 230.216 Flash Point 182.5±27.9 °C Exact Mass 230.057907 PSA 52.58000 LogP 2.26 Vapour Pressure 0.0±0.9 mmHg at 25°C Index of Refraction 1.613 InChIKey NZVQLVGOZRELTG-UHFFFAOYSA-N SMILES COc1c2ccoc2cc2oc(C)cc(=O)c12 |
| Use of | Visnagin, an antioxidant furanocoumarin derivative, possess anti-inflammatory and analgesic properties. Visnagin has substantial potential to prevent Cerulein induced acute pancreatitis (AP). Visnagin possess promising vasodilator effects in vascular smooth muscles[1][2]. Properties Name 4-methoxy-7-methylfuro[3,2-g]chromen-5-one Synonym More Synonyms Visnagin Biological Activity Description Visnagin, an antioxidant furanocoumarin derivative, possess anti-inflammatory and analgesic properties. Visnagin has substantial potential to prevent Cerulein induced acute pancreatitis (AP). Visnagin possess promising vasodilator effects in vascular smooth muscles[1][2]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease References [1]. Radim Vrzal, et al. Khellin and visnagin differentially modulate AHR signaling and downstream CYP1A activity in human liver cells. PLoS One. 2013 Sep 19;8(9):e74917. Chemical & Physical Properties Molecular Formula C13H10O4 Exact Mass 230.057907 PSA 52.58000 Index of Refraction 1.613 InChIKey NZVQLVGOZRELTG-UHFFFAOYSA-N |
| Transport Info | Product name: Purity: 96.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available |
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