CAS Number42971-09-5
SynonymsEINECS 256-028-0; (3α,16α)-Eburnamenine-14-carboxylic acid ethyl ester; vinpocetine; MFCD00211233; Eburnamenine-14-carboxylic acid ethyl ester
Molecular FormulaC22H26N2O2
Molecular Weight350.46
Purity99%
Density1.3±0.1 g/cm3
Boiling Point419.5±45.0 °C at 760 mmHg
Melting Point147-153ºC dec
AppearanceWhite crystalline solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 42971-09-5 |
| Catalog No. | 2A-9012938 |
| Chinese Name | 长春西汀 |
| Synonyms | EINECS 256-028-0; (3α,16α)-Eburnamenine-14-carboxylic acid ethyl ester; vinpocetine; MFCD00211233; Eburnamenine-14-carboxylic acid ethyl ester |
| Molecular Formula | C22H26N2O2 |
| Molecular Weight | 350.46 |
| Purity | 99 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 419.5±45.0 °C at 760 mmHg |
| Melting Point | 147-153ºC dec |
| Appearance | White crystalline solid |
| Storage Condition | Sealed, cool, dry storage |
| Application | Vinpocetine (Cavinton; Ethyl apovincaminate) is a selective inhibitor of PDE1 with an IC50 of 21 μM. It is also a pressure-sensitive sodium ion channel. |
| HTC | 2933990090 |
| MDL Number | C22H26N2O2 |
| SMILES | CCOC(=O)C1=CC2(CC)CCCN3CCc4c(n1c1ccccc41)C32 |
| InChI | InChI=1S/C22H26N2O2/c1-3-22-11-7-12-23-13-10-16-15-8-5-6-9-17(15)24(19(16)20(22)23)18(14-22)21(25)26-4-2/h5-6,8-9,14,20H,3-4,7,10-13H2,1-2H3/t20-,22+/m1/s1 |
| InChI Key | DDNCQMVWWZOMLN-IRLDBZIGSA-N |
| MSDS | msds/12938_1_42971_09_5.pdf |
| Bioactivity | Vinpocetine(Cavinton; Ethyl apovincaminate) is a selective for PDE1 (IC50 = 21 μM). Also blocks voltage-gated Na+ channels.IC50 value:Target: PDE1; Na+ channel Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Cardiovascular Disease Research Areas >> Neurological Disease References [1]. Patyar S, et al. Role of vinpocetine in cerebrovascular diseases.Pharmacol Rep. 2011;63(3):618-28. [2]. Vaizova OE, et al. Endothelium-protective effects of vinpocetine, pentoxifylline and enalapril in patients with chronic brain ischemia.Eksp Klin Farmakol. 2011;74(4):10-3. [3]. El-Laithy HM, et al. Novel sugar esters proniosomes for transdermal delivery of vinpocetine: preclinical and clinical studies.Eur J Pharm Biopharm. 2011 Jan;77(1):43-55. [4]. Alexandre E. Medina Vinpocetine as a potent antiinflammatory agent PNAS June 1, 2010 vol. 107 no. 22 9921-9922 [5]. Kye-Im Jeon et al. Vinpocetine inhibits NF-κB-dependent inflammation via an IKK-dependent but PDE-independent mechanism PNAS May 25, 2010 vol. 107 no. 21 9795-9800 Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 419.5±45.0 °C at 760 mmHg Melting Point 147-153ºC dec Molecular Formula C22H26N2O2 Molecular Weight 350.454 Flash Point 207.5±28.7 °C Exact Mass 350.199432 PSA 34.47000 LogP 5.14 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.666 InChIKey DDNCQMVWWZOMLN-IRLDBZIGSA-N SMILES CCOC(=O)C1=CC2(CC)CCCN3CCc4c(n1c1ccccc41)C32 |
| Use of | Vinpocetine(Cavinton; Ethyl apovincaminate) is a selective for PDE1 (IC50 = 21 μM). Also blocks voltage-gated Na+ channels.IC50 value:Target: PDE1; Na+ channel Properties Articles30 Name Vinpocetine Synonym More Synonyms Vinpocetine Biological Activity Description Vinpocetine(Cavinton; Ethyl apovincaminate) is a selective for PDE1 (IC50 = 21 μM). Also blocks voltage-gated Na+ channels.IC50 value:Target: PDE1; Na+ channel Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Cardiovascular Disease Research Areas >> Neurological Disease References [1]. Patyar S, et al. Role of vinpocetine in cerebrovascular diseases.Pharmacol Rep. 2011;63(3):618-28. [2]. Vaizova OE, et al. Endothelium-protective effects of vinpocetine, pentoxifylline and enalapril in patients with chronic brain ischemia.Eksp Klin Farmakol. 2011;74(4):10-3. [3]. El-Laithy HM, et al. Novel sugar esters proniosomes for transdermal delivery of vinpocetine: preclinical and clinical studies.Eur J Pharm Biopharm. 2011 Jan;77(1):43-55. [4]. Alexandre E. Medina Vinpocetine as a potent antiinflammatory agent PNAS June 1, 2010 vol. 107 no. 22 9921-9922 [5]. Kye-Im Jeon et al. Vinpocetine inhibits NF-κB-dependent inflammation via an IKK-dependent but PDE-independent mechanism PNAS May 25, 2010 vol. 107 no. 21 9795-9800 Chemical & Physical Properties Molecular Formula C22H26N2O2 Exact Mass 350.199432 PSA 34.47000 Index of Refraction 1.666 InChIKey DDNCQMVWWZOMLN-IRLDBZIGSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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