CAS Number60643-86-9
Synonymsvigabatrinum; 4-Aminohex-5-enoic acid; Sabril; EINECS 200-659-6; 4-Amino-5-hexenoic acid; UNII:GR120KRT6K; vigabatrinum [INN_la]; vigabatrine; MFCD00274577; Vigabatrin; vigabatrina; (±)-Vigabatrin
Molecular FormulaC6H11NO2
Molecular Weight129.16
Purity98.00%
Density1.1±0.1 g/cm3
Boiling Point277.7±28.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 60643-86-9 |
| Catalog No. | 2A-0202088 |
| Chinese Name | 氨己烯酸 |
| Synonyms | vigabatrinum; 4-Aminohex-5-enoic acid; Sabril; EINECS 200-659-6; 4-Amino-5-hexenoic acid; UNII:GR120KRT6K; vigabatrinum [INN_la]; vigabatrine; MFCD00274577; Vigabatrin; vigabatrina; (±)-Vigabatrin |
| Molecular Formula | C6H11NO2 |
| Molecular Weight | 129.16 |
| Purity | 98.00 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 277.7±28.0 °C at 760 mmHg |
| Storage Condition | Desiccate at +4°C |
| HTC | 2922499990 |
| MDL Number | C6H11NO2 |
| SMILES | NC(CCC(O)=O)C=C |
| InChI | InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9) |
| InChI Key | InChIKey=PJDFLNIOAUIZSL-UHFFFAOYSA-N |
| MSDS | msds/12928_1_60643_86_9.pdf |
| Use of | Vigabatrin, also known as gamma-vinyl-GABA, is an antiepileptic drug that inhibits the breakdown of γ-aminobutyric acid (GABA) by acting as a suicide inhibitor of GABA transaminase (GABA-T). It is a structural analog of GABA, but does not bind to GABA receptors. Vigabatrin is an irreversible suicide inhibitor of gamma-aminobutyric acid transaminase (GABA-T), the enzyme responsible for the catabolism of GABA, which increases the level of GABA in the brain. Vigabatrin is a racemic compound, and its [S]-enantiomer is pharmacologically active. Properties Articles51 Name vigabatrin Synonym More Synonyms Chemical & Physical Properties Molecular Formula C6H11NO2 Exact Mass 129.078979 PSA 63.32000 LogP -0.10 Index of Refraction 1.483 Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 5-Hexenoic acid, 4-amino- CAS REGISTRY NUMBER : 60643-86-9 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C6-H11-N-O2 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Human - woman DOSE/DURATION : TOXIC EFFECTS : Brain and Coverings - changes in surface EEG Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 342,185,1993 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Human - man DOSE/DURATION : TOXIC EFFECTS : Brain and Coverings - changes in surface EEG Behavioral - hallucinations, distorted perceptions Behavioral - toxic psychosis REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 342,619,1993 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Skin and Appendages - hair REFERENCE : NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.9- 1970- Volume(issue)/page/year: 21,803,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Brain and Coverings - other degenerative changes Behavioral - food intake (animal) Related to Chronic Data - death REFERENCE : TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - retinal changes (pigmentary depositions, retinitis, other) Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Mammal - dog DOSE/DURATION : TOXIC EFFECTS : Brain and Coverings - other degenerative changes REFERENCE : TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Mammal - dog DOSE/DURATION : TOXIC EFFECTS : Brain and Coverings - other degenerative changes Related to Chronic Data - death REFERENCE : TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SEX/DURATION : female 18 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 53,34A,1996 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - other effects to embryo Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 55,165,1997 Safety Information GHS02, GHS06, GHS08 Signal Word Danger Hazard Statements H225-H301 + H311 + H331-H370 Precautionary Statements P210-P260-P280-P301 + P310-P311 Hazard Codes Xi Safety Phrases S26-S36 RIDADR MP7745000 WGK Germany 2 RTECS MP7745000 HS Code 2922499990 Precursor & DownStream Precursor 9 CAS#:7529-16-0 5-Vinylpyrrolid... CAS#:144085-15-4 4-benzenesulpho... CAS#:440366-57-4 4-(carbobenzylo... CAS#:54653-25-7 Ethyl 5-Hexenoate DownStream 2 CAS#:105457-53-2 4-amino-5-fluor... CAS#:7529-16-0 5-Vinylpyrrolid... |
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