CAS Number5011-34-7
SynonymsTrimetazidine HCl; EINECS 225-690-2; MFCD00868263; Trimetazidine; 1-(2,3,4-Trimethoxybenzyl)(2,2,3,3,5,5,6,6-H)piperazine
Molecular FormulaC15H23O4N2Cl1
Molecular Weight330.81
Purity98%
Density1.1±0.1 g/cm3
Boiling Point364.0±37.0 °C at 760 mmHg
Melting Point200 - 205ºC
AppearanceWhite or off-white crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 5011-34-7 |
| Catalog No. | 2A-9012847 |
| Chinese Name | 曲美他嗪 |
| Synonyms | Trimetazidine HCl; EINECS 225-690-2; MFCD00868263; Trimetazidine; 1-(2,3,4-Trimethoxybenzyl)(2,2,3,3,5,5,6,6-H)piperazine |
| Molecular Formula | C15H23O4N2Cl1 |
| Molecular Weight | 330.81 |
| Purity | 98 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 364.0±37.0 °C at 760 mmHg |
| Melting Point | 200 - 205ºC |
| Appearance | White or off-white crystalline powder |
| Application | Trimetazidine is a selective long-chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM that inhibits beta-oxidation of free fatty acids. Trimetazidine is a potent antianginal agent and a |
| HTC | 2933599090 |
| MDL Number | MFCD22573487 |
| SMILES | COc1ccc(CN2CCNCC2)c(OC)c1OC |
| InChI | InChI=1S/C14H22N2O3/c1-17-12-5-4-11(13(18-2)14(12)19-3)10-16-8-6-15-7-9-16/h4-5,15H,6-10H2,1-3H3 |
| InChI Key | UHWVSEOVJBQKBE-UHFFFAOYSA-N |
| MSDS | msds/12847_1_5011_34_7.pdf |
| Use of | Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine is an effective antianginal agent and a cytoprotective drug, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine triggers autophagy. Trimetazidine is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor[1][2][3][4]. Properties Name 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine Synonym More Synonyms Trimetazidine Biological Activity Description Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine is an effective antianginal agent and a cytoprotective drug, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine triggers autophagy. Trimetazidine is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor[1][2][3][4]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Autophagy >> Autophagy IC50: 75 nM (long chain 3-ketoyl coenzyme A thiolase)[2] β-oxidation[2] Autophagy[3] 3-hydroxyacyl-CoA dehydrogenase (HADHA)[4] In Vitro Trimetazidine (1-100 μM; 24 hours; HUVECs) could enhance the viability of the injured HUVECs induced by oxidation in a certain dose-dependent manner[1]. Cell Viability Assay[1] Cell Line: Human umbilical vein endothelial cells (HUVECs) Concentration: 1 μM,10 μM,100 μM Incubation Time: 24 hours Result: Enhanced the viability of the injured HUVECs induced by oxidation. References [1]. Shenghu He, et al. Protective effects of trimetazidine against vascular endothelial cell injury induced by oxidation. Journal of Geriatric Cardiology, December 2008 , Vol 5 No 4. [2]. Chrusciel P, et al. Defining the role of trimetazidine in the treatment of cardiovascular disorders: some insights on its role in heart failure and peripheral artery disease. Drugs. 2014 Jun;74(9):971-80. [3]. Kantor PF, et al. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res. 2000 Mar 17;86(5):580-8. [4]. Hossain F, et al.Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies. Cancer Immunol Res. 2015 Nov;3(11):1236-47. [5]. Jain S, et al. Trimetazidine exerts protection against increasing current electroshock seizure test in mice. Seizure. 2010 Jun;19(5):300-2. Chemical & Physical Properties Molecular Formula C14H22N2O3 Exact Mass 274.213257 PSA 42.96000 Index of Refraction 1.524 InChIKey UHWVSEOVJBQKBE-UHFFFAOYSA-N Safety Information Hazard Codes Xi HS Code 2933599090 Synthetic Route Total: 1 Page Trimetazidine N... CAS#:53531-01-4 Trimetazidine CAS#:5011-34-7 Literature: Ferte, Jacques; Kuehnel, Jean-Marc; Chapuis, Genevieve; Rolland, Yves; Lewin, Guy; Schwaller, Marc A. Journal of Medicinal Chemistry, 1999 , vol. 42, # 3 p. 478 - 489 2,3,4-Trimethox... CAS#:2103-57-3 Trimetazidine CAS#:5011-34-7 Literature: Ferte, Jacques; Kuehnel, Jean-Marc; Chapuis, Genevieve; Rolland, Yves; Lewin, Guy; Schwaller, Marc A. Journal of Medicinal Chemistry, 1999 , vol. 42, # 3 p. 478 - 489 Precursor & DownStream Precursor 2 CAS#:53531-01-4 Trimetazidine N... CAS#:2103-57-3 2,3,4-Trimethox... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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