CAS Number4641-57-0
Synonyms1-Phenyl-2-pyrrolidinone; N-Phenylbutyrolactam; N-(phenyl)-2-pyrrolidinone; EINECS 225-069-6; N-phenylpyrrolidinone; 1-PHENYL-2-PYRROLIDONE; N-Phenylbutyrolactame; N-Phenyl-2-pyrrolidone; 1-phenylpyrrolidin-2-one; N-PHENYL PYRROLIDONE; MFCD00003192; 1-phenyl-azacyclopentan-2-one; N-Phenyl-2-pyrrolidinone; N-phenyl-pyrrolidin-2-one; Phenylpyrrolidone
Molecular FormulaC10H11NO
Molecular Weight161.20
Purity99%
Density1.1±0.1 g/cm3
Boiling Point123 °C/0.2 mmHg (lit.)
Melting Point67-69 °C (lit.)
Appearancesolid
EINECS225-069-6
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 4641-57-0 |
| Catalog No. | 2A-9001281 |
| Chinese Name | 1-苯基-2-吡咯烷酮 |
| Synonyms | 1-Phenyl-2-pyrrolidinone; N-Phenylbutyrolactam; N-(phenyl)-2-pyrrolidinone; EINECS 225-069-6; N-phenylpyrrolidinone; 1-PHENYL-2-PYRROLIDONE; N-Phenylbutyrolactame; N-Phenyl-2-pyrrolidone; 1-phenylpyrrolidin-2-one; N-PHENYL PYRROLIDONE; MFCD00003192; 1-phenyl-azacyclopentan-2-one; N-Phenyl-2-pyrrolidinone; N-phenyl-pyrrolidin-2-one; Phenylpyrrolidone |
| Molecular Formula | C10H11NO |
| Molecular Weight | 161.20 |
| Purity | 99 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 123 °C/0.2 mmHg (lit.) |
| Melting Point | 67-69 °C (lit.) |
| Appearance | solid |
| Storage Condition | Store at room temperature, away from light, in a v |
| Application | 1-Phenyl-2-pyrrolidinone (1-Phenylpyrrolidin-2-one) is a GABA analog that has sedative effects and can reduce exploratory behavior in rats at 50-100 mg/kg (intravenous injection). 1-Phenyl-2-pyrrolidi |
| EINECS | 225-069-6 |
| HTC | 2933790090 |
| PubChem ID | 24858557 |
| MDL Number | MFCD00003192 |
| SMILES | O=C1CCCN1c2ccccc2 |
| InChI | 1S/C10H11NO/c12-10-7-4-8-11(10)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2 |
| InChI Key | JMVIVASFFKKFQK-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | Xi |
| Risk Codes | R36/37/38 |
| Safety Description | S26;S37/39 |
| MSDS | msds/1281_1_4641_57_0.pdf |
| Bioactivity | 1-Phenyl-2-pyrrolidinone (1-Phenylpyrrolidin-2-one) is a phenyl analogue of GABA with sedative effect, decreasing the exploratory behavior of rats at 50-100 mg/kg (i.v.). 1-Phenyl-2-pyrrolidinone also has been proved to inhibit emotional reactions in dogs and cats. 1-Phenyl-2-pyrrolidinone induces decreases in the pressor reaction to emotional stress without accompanied by normalization of the function of baroreceptor reflexes[1][2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor References [1]. Patkina N, et al. Some psychotropic effects of phenibut and phenylpyrrolidone. Trudy Volgogradskogo Gosudarstvennogo Meditsinskogo Instituta (1979), 31(3), 63-6. [2]. Kovalev GV, et al. Effect of γ-aminobutyric acid derivatives on baroreceptor reflexes in nonanesthetized animals. Russian. 1980, (VINITI 1311-80), 10 pp. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 355.5±11.0 °C at 760 mmHg Melting Point 67-69 °C(lit.) Molecular Formula C10H11NO Molecular Weight 161.20 Flash Point 174.7±10.5 °C Exact Mass 161.084061 PSA 20.31000 LogP 1.39 Vapour Pressure 0.0±0.8 mmHg at 25°C Index of Refraction 1.578 InChIKey JMVIVASFFKKFQK-UHFFFAOYSA-N SMILES O=C1CCCN1c1ccccc1 Storage condition Refrigerator |
| Use of | Properties Name 1-Phenyl-2-pyrrolidinone Synonym More Synonyms Phenylpyrrolidone Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor References [1]. Patkina N, et al. Some psychotropic effects of phenibut and phenylpyrrolidone. Trudy Volgogradskogo Gosudarstvennogo Meditsinskogo Instituta (1979), 31(3), 63-6. [2]. Kovalev GV, et al. Effect of γ-aminobutyric acid derivatives on baroreceptor reflexes in nonanesthetized animals. Russian. 1980, (VINITI 1311-80), 10 pp. Chemical & Physical Properties Molecular Formula C10H11NO Exact Mass 161.084061 PSA 20.31000 Index of Refraction 1.578 InChIKey JMVIVASFFKKFQK-UHFFFAOYSA-N Storage condition Refrigerator |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 9.0% Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0% |
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