CAS Number112192-04-8
SynonymsRoxindole; RoxindoleHCl; Roxindole hydrochloride,3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-olhydrochloride; ROXINDOLE HYDROCHLORIDE
Molecular FormulaC23H26N2O
Molecular Weight346.47
Purity96+%
Density1.173g/cm3
Boiling Point575.7ºC at 760mmHg
EINECS0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 112192-04-8 |
| Catalog No. | 2A-0127284 |
| Chinese Name | 罗新朵 |
| Synonyms | Roxindole; RoxindoleHCl; Roxindole hydrochloride,3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-olhydrochloride; ROXINDOLE HYDROCHLORIDE |
| Molecular Formula | C23H26N2O |
| Molecular Weight | 346.47 |
| Purity | 96+ |
| Density | 1.173g/cm3 |
| Boiling Point | 575.7ºC at 760mmHg |
| Storage Condition | -20°C, sealed, dry |
| Application | Roindole (EMD 49980), an indole alkylpiperidine, is a potent agonist of dopamine autoreceptors with affinity for the D2-like isoform in the low nanomolar range. Roindole can be used to study positive |
| EINECS | 0 |
| HTC | 2933990090 |
| UN(IATA) | 0 |
| PubChem ID | 6349747 |
| MDL Number | C23H26N2O |
| SMILES | Oc1ccc2[nH]cc(CCCCN3CC=C(c4ccccc4)CC3)c2c1 |
| InChI | InChI=1S/C23H26N2O/c26-21-9-10-23-22(16-21)20(17-24-23)8-4-5-13-25-14-11-19(12-15-25)18-6-2-1-3-7-18/h1-3,6-7,9-11,16-17,24,26H,4-5,8,12-15H2 |
| InChI Key | HGEYJZMMUGWEOT-UHFFFAOYSA-N |
| Use of | Roxindole (EMD 49980), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT1A agonist and 5-HT uptake inhibitor with high affinity for 5-HT1A (IC50=0.9 nM). Antipsychotic and antidepressant activities[1][2][3]. Properties Name roxindole Synonym More Synonyms Roxindole Biological Activity Description Roxindole (EMD 49980), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT1A agonist and 5-HT uptake inhibitor with high affinity for 5-HT1A (IC50=0.9 nM). Antipsychotic and antidepressant activities[1][2][3]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter References [1]. Bartoszyk GD, Harting J, Minck KO. Roxindole: psychopharmacological profile of a dopamine D2 autoreceptor agonist. J Pharmacol Exp Ther. 1996;276(1):41-48. [2]. Wetzel H, et al. Roxindole, a dopamine autoreceptor agonist, in the treatment of positive and negative schizophrenic symptoms. Am J Psychiatry. 1994;151(10):1499-1502. [3]. Maj J, et al. Roxindole, a dopamine autoreceptor agonist with a potential antidepressant activity. II. Effects on the 5-hydroxytryptamine system. Pharmacopsychiatry. 1997;30(2):55-61. [4]. Bartoszyk GD, et al. Roxindole: psychopharmacological profile of a dopamine D2 autoreceptor agonist. J Pharmacol Exp Ther. 1996;276(1):41-48. Chemical & Physical Properties Molecular Formula C23H26N2O Exact Mass 346.20500 PSA 39.26000 LogP 4.92340 Index of Refraction 1.651 InChIKey HGEYJZMMUGWEOT-UHFFFAOYSA-N Safety Information HS Code 2933990090 Synthetic Route 5-methoxy-3-[3-... CAS#:143682-61-5 CAS#:112192-04-8 Literature: Lange, Jos H. M.; De Jong, Johannes C.; Sanders, Hans J.; Visser, Geb M.; Kruse, Chris G. Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 7 p. 1055 - 1056 4-(5-Methoxy-1H... CAS#:83696-90-6 CAS#:112192-04-8 Literature: Bottcher; Barnickel; Hausberg; Haase; Seyfried; Eiermann Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4020 - 4026 4-phenyl-1,2,3,... CAS#:43064-12-6 CAS#:112192-04-8 Literature: Bottcher; Barnickel; Hausberg; Haase; Seyfried; Eiermann Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4020 - 4026 Precursor & DownStream Precursor 4 CAS#:143682-61-5 5-methoxy-3-[3-... CAS#:83696-90-6 4-(5-Methoxy-1H... CAS#:43064-12-6 4-phenyl-1,2,3,... CAS#:1006-94-6 5-Methoxyindole DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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