CAS Number5630-53-5
SynonymsEINECS 227-069-1; 17-Hydroxy-7α-methyl-19-nor-17α-pregn-5(10)-en-20-yn-3-one; Tibolone; 7a-Methyl-5,10-norethindrone; 7a-Methyl-17a-ethynyl-17b-hydroxy-19-norandrost-5(10)-en-3-one; LIVIELLA; Org OD 14; (7α,17α)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one; 7a-Methyl-D5,10-norethindrone; Livial; 7a-Methyl-17a-ethynyl-17b-hydroxyestr-5(10)-en-3-one; MFCD00864178; (7a,17a)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one
Molecular FormulaC21H28O2
Molecular Weight312.45
Purity98%
Density1.1±0.1 g/cm3
Boiling Point447.4±45.0 °C at 760 mmHg
Melting Point165-169 °C
AppearanceWhite to off-white crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 5630-53-5 |
| Catalog No. | 2A-9012710 |
| Chinese Name | 替勃龙 |
| Synonyms | EINECS 227-069-1; 17-Hydroxy-7α-methyl-19-nor-17α-pregn-5(10)-en-20-yn-3-one; Tibolone; 7a-Methyl-5,10-norethindrone; 7a-Methyl-17a-ethynyl-17b-hydroxy-19-norandrost-5(10)-en-3-one; LIVIELLA; Org OD 14; (7α,17α)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one; 7a-Methyl-D5,10-norethindrone; Livial; 7a-Methyl-17a-ethynyl-17b-hydroxyestr-5(10)-en-3-one; MFCD00864178; (7a,17a)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one |
| Molecular Formula | C21H28O2 |
| Molecular Weight | 312.45 |
| Purity | 98 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 447.4±45.0 °C at 760 mmHg |
| Melting Point | 165-169 °C |
| Appearance | White to off-white crystalline powder |
| Storage Condition | Keep away from light, cool and dry place, sealed a |
| Application | Tibolone is a broad-spectrum gonadal steroid agonist with progestogenic, androgenic, and estrogenic activities. Tibolone can be used in the study of postmenopausal osteoporosis [1][2]. |
| SMILES | O[C@@]1([C@@]2([C@H]([C@H]3[C@H](CC2)C4=C(C[C@H]3C)CC(=O)CC4)CC1)C)C#C |
| InChI | 1S/C21H28O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,13,17-19,23H,5-12H2,2-3H3/t13-,17-,18+,19-,20+,21+/m1/s1 |
| InChI Key | WZDGZWOAQTVYBX-XOINTXKNSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/12710_1_5630_53_5.pdf |
| Bioactivity | Tibolone is a broad spectrum gonadal steroid agonist with progestagenic, androgenic, and estrogenic activities. Tibolone can be used for postmenopausal osteoporosis research[1][2]. Related Catalog Signaling Pathways >> Others >> Estrogen Receptor/ERR Signaling Pathways >> Others >> Progesterone Receptor Research Areas >> Endocrinology Signaling Pathways >> Others >> Androgen Receptor In Vivo Tibolone (1 mg/day; oral administration; for 12 weeks) treatment enhances the osseointegration process of intramedullary titanium implants in ovariectomized rats[1]. Animal Model: Female albino Wistar rats bearing ovariectomy[1] Dosage: 1 mg/day Administration: Oral administration; daily; for 12 weeks Result: Showed a significantly higher overall bone tissue and a higher body mass density. References [1]. Dragos Apostu, et al. Tibolone, alendronate, and simvastatin enhance implant osseointegration in a preclinical in vivo model. Clin Oral Implants Res. 2020 Jul;31(7):655-668. [2]. Marcos García-Juárez, et al. Tibolone induces lordosis behavior, but not concurrent or sequential inhibition, in Sprague Dawley rats. Neurosci Lett. 2021 Apr 24;755:135916. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 447.4±45.0 °C at 760 mmHg Melting Point 169 °C Molecular Formula C21H28O2 Molecular Weight 312.446 Flash Point 190.6±21.3 °C Exact Mass 312.208923 PSA 37.30000 LogP 4.03 Vapour Pressure 0.0±2.5 mmHg at 25°C Index of Refraction 1.570 InChIKey WZDGZWOAQTVYBX-XOINTXKNSA-N SMILES C#CC1(O)CCC2C3C(C)CC4=C(CCC(=O)C4)C3CCC21C Storage condition 2-8°C |
| Use of | Tibolone is a broad spectrum gonadal steroid agonist with progestagenic, androgenic, and estrogenic activities. Tibolone can be used for postmenopausal osteoporosis research[1][2]. Properties Articles54 Name tibolone Synonym More Synonyms Tibolone(Liviella)(Livial) Biological Activity Description Tibolone is a broad spectrum gonadal steroid agonist with progestagenic, androgenic, and estrogenic activities. Tibolone can be used for postmenopausal osteoporosis research[1][2]. Related Catalog Signaling Pathways >> Others >> Estrogen Receptor/ERR Signaling Pathways >> Others >> Progesterone Receptor Research Areas >> Endocrinology Signaling Pathways >> Others >> Androgen Receptor References [1]. Dragos Apostu, et al. Tibolone, alendronate, and simvastatin enhance implant osseointegration in a preclinical in vivo model. Clin Oral Implants Res. 2020 Jul;31(7):655-668. [2]. Marcos García-Juárez, et al. Tibolone induces lordosis behavior, but not concurrent or sequential inhibition, in Sprague Dawley rats. Neurosci Lett. 2021 Apr 24;755:135916. Chemical & Physical Properties Molecular Formula C21H28O2 Exact Mass 312.208923 PSA 37.30000 Index of Refraction 1.570 InChIKey WZDGZWOAQTVYBX-XOINTXKNSA-N |
| Transport Info | Product name: Tibolone (Liviella) (Livial) |
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