| Chemical & Physical Properties | |
|---|---|
| CAS Number | 886362-90-9 |
| Catalog No. | 2A-0126542 |
| Chinese Name | 3-[2-(3-乙氧基-3-羰基丙氧基)-乙氧基]-丙酸 |
| Synonyms | 3-[2-(3-ethoxy-3-oxopropoxy)ethoxy]propanoic acid |
| Molecular Formula | C10H18O6 |
| Molecular Weight | 234.25 |
| Purity | 96+ |
| Density | 1.145g/cm3 |
| Boiling Point | 370.8ºC at 760 mmHg |
| Storage Condition | room temperature, dry |
| Application | Acid-PEG2-ethyl propionate is a PROTAC linker and belongs to the PEG class. Can be used to synthesize PROTAC molecules. |
| EINECS | 0 |
| HTC | 2918990090 |
| UN(IATA) | 0 |
| PubChem ID | 90444215 |
| MDL Number | MFCD04115349 |
| SMILES | CCOC(=O)CCOCCOCCC(=O)O |
| InChI | InChI=1S/C10H18O6/c1-2-16-10(13)4-6-15-8-7-14-5-3-9(11)12/h2-8H2,1H3,(H,11,12) |
| InChI Key | KEGUKRRJONEXNN-UHFFFAOYSA-N |
| Use of | Acid-PEG2-ethyl propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Properties Name 3-(2-(3-Ethoxy-3-oxopropoxy)ethoxy)propanoic acid Synonym More Synonyms Acid-PEG2-ethyl propionate Biological Activity Description Acid-PEG2-ethyl propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Molecular Formula C10H18O6 Exact Mass 234.11000 PSA 82.06000 LogP 0.44750 Index of Refraction 1.452 InChIKey KEGUKRRJONEXNN-UHFFFAOYSA-N SMILES CCOC(=O)CCOCCOCCC(=O)O Safety Information Hazard Codes Xi HS Code 2918990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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