CAS Number57260-71-6
Synonymspiperazine-1-carboxylic acid tert-butyl ester; 1-Piperazinecarboxylic acid, 1,1-dimethylethyl ester; BOC-PIPERAZINE; 2-Methyl-2-propanyl 1-piperazinecarboxylate; 1-Boc piperzine; t-Butyl 1-piperazincarboxylate; tert-butyl piperazine-1-carboxylate; 1,1-Dimethylethyl 1-piperazinecarboxylate; 1-BOC-Piperazine; PIBOC; MFCD00075265; tert-butyl tetrahydropyrazine-1(2H)-carboxylate; N-BOC-PIPERAZINE; tert-butyl l-piperazinecarboxylate; 1-N-BOC-PIPERAZINE; RARECHEM AR PA 0026; BOC-PAZ; N-Boc-piperazine; tert-butyl piperazine-1-carboxylate; tert-Butyl 1-piperazinecarboxylate; N-Boc-piperazine; N Boc-Piperazine
Molecular FormulaC9H18N2O2
Molecular Weight186.25
Purity97%
Density1.0±0.1 g/cm3
Boiling Point258.0±15.0 °C at 760 mmHg
Melting Point43-47 °C (lit.)
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 57260-71-6 |
| Catalog No. | 2A-9001261 |
| Chinese Name | 1-Boc-哌嗪 |
| Synonyms | piperazine-1-carboxylic acid tert-butyl ester; 1-Piperazinecarboxylic acid, 1,1-dimethylethyl ester; BOC-PIPERAZINE; 2-Methyl-2-propanyl 1-piperazinecarboxylate; 1-Boc piperzine; t-Butyl 1-piperazincarboxylate; tert-butyl piperazine-1-carboxylate; 1,1-Dimethylethyl 1-piperazinecarboxylate; 1-BOC-Piperazine; PIBOC; MFCD00075265; tert-butyl tetrahydropyrazine-1(2H)-carboxylate; N-BOC-PIPERAZINE; tert-butyl l-piperazinecarboxylate; 1-N-BOC-PIPERAZINE; RARECHEM AR PA 0026; BOC-PAZ; N-Boc-piperazine; tert-butyl piperazine-1-carboxylate; tert-Butyl 1-piperazinecarboxylate; N-Boc-piperazine; N Boc-Piperazine |
| Molecular Formula | C9H18N2O2 |
| Molecular Weight | 186.25 |
| Purity | 97 |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 258.0±15.0 °C at 760 mmHg |
| Melting Point | 43-47 °C (lit.) |
| Appearance | solid |
| Water Solubility | Soluble in: methanol |
| Storage Condition | Keep the receptacle sealed, stored in a cool, dry |
| Application | N-Boc-piperazine is a PROTAC linker, belonging to the Alkyl/ether class. Can be used to synthesize PROTAC PD-1/PD-L1 degrader-1 (HY-131183). |
| HTC | 2933990090 |
| PubChem ID | 24861171 |
| MDL Number | MFCD00075265 |
| SMILES | CC(C)(C)OC(=O)N1CCNCC1 |
| InChI | 1S/C9H18N2O2/c1-9(2,3)13-8(12)11-6-4-10-5-7-11/h10H,4-7H2,1-3H3 |
| InChI Key | CWXPZXBSDSIRCS-UHFFFAOYSA-N |
| Beilstein/REAXYS | 879985 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | Transport |
| Risk Codes | S26 |
| Safety Description | R36/37/38 |
| MSDS | msds/1261_1_57260_71_6.pdf |
| Bioactivity | N-Boc-piperazine is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183)[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Target Alkyl/ether In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. Binbin Cheng, et al. Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1. Eur J Med Chem. 2020;199:112377. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 258.0±15.0 °C at 760 mmHg Melting Point 47-49ºC Molecular Formula C9H18N2O2 Molecular Weight 186.251 Flash Point 109.8±20.4 °C Exact Mass 186.136826 PSA 41.57000 LogP 0.55 Vapour Pressure 0.0±0.5 mmHg at 25°C Index of Refraction 1.467 InChIKey CWXPZXBSDSIRCS-UHFFFAOYSA-N SMILES CC(C)(C)OC(=O)N1CCNCC1 Storage condition Refrigerator |
| Use of | Properties Name 1-Boc-piperazine Synonym More Synonyms N-Boc-piperazine Biological Activity Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Alkyl/ether In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. Binbin Cheng, et al. Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1. Eur J Med Chem. 2020;199:112377. Chemical & Physical Properties Molecular Formula C9H18N2O2 Exact Mass 186.136826 PSA 41.57000 Index of Refraction 1.467 InChIKey CWXPZXBSDSIRCS-UHFFFAOYSA-N Storage condition Refrigerator |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 0.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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