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Tandutinib structure, CAS 387867-13-2

Tandutinib

CAS Number387867-13-2

SynonymsMLN 518; Tandutinib; UNII:E1IO3ICJ9A; Unii-E1io3icj9a

Molecular FormulaC31H42N6O4

Molecular Weight562.70 (free base basis)

Purity≥98 (HPLC)%

Density1.2±0.1 g/cm3

Boiling Point769.5±60.0 °C at 760 mmHg

Melting Point177-178°C

Flash Point

Appearancepowder

EINECS

MSDSChineseEnglish

Symbol6.1

Signal WordWarning

Cat. No.: 2A-9012578 Purity: ≥98 (HPLC)%
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Quality Control of [ 387867-13-2 ] Purity: ≥98 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number387867-13-2
Catalog No.2A-9012578
Chinese Name坦度替尼
SynonymsMLN 518; Tandutinib; UNII:E1IO3ICJ9A; Unii-E1io3icj9a
Molecular FormulaC31H42N6O4
Molecular Weight562.70 (free base basis)
Purity≥98 (HPLC)
Density1.2±0.1 g/cm3
Boiling Point769.5±60.0 °C at 760 mmHg
Melting Point177-178°C
Appearancepowder
Storage ConditionRefrigerator
PackagingII
ApplicationTandutinib (MLN518, CT53518) is a FLT3 antagonist with an IC50 of 0.22 μM and also inhibits PDGFR and c-Kit.
HTC29154000
SMILESN5(CCCCC5)CCCOc1cc2ncnc(c2cc1OC)N3CCN(CC3)C(=O)Nc4ccc(cc4)OC(C)C
InChI1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38)
InChI KeyUXXQOJXBIDBUAC-UHFFFAOYSA-N
NACRES CodeNA.77
UNSPSC12352200
Hazard Symbols6.1
MSDSmsds/12578_1_387867_13_2.pdf
Use ofProperties Name Tandutinib(CT 53518) Synonym More Synonyms Tandutinib (MLN518) Biological Activity Related Catalog Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3 Research Areas >> Cancer References [1]. Kelly LM, et al. CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML). Cancer Cell, 2002, 1(5), 421-432. [2]. Griswold IJ, et al. Effects of MLN518, a dual FLT3 and KIT inhibitor, on normal and malignant hematopoiesis. Blood, 2004, 104(9), 2912-2918. [3]. Schittenhelm MM, et al. The FLT3 inhibitor tandutinib (formerly MLN518) has sequence-independent synergistic effects with cytarabine and daunorubicin. Cell Cycle, 2009, 8(16), 2621-2630. [4]. Salama Y, et al. The angiogenic factor Egfl7 alters thymogenesis by activating Flt3 signaling. Biochem Biophys Res Commun. 2017 Aug 19;490(2):209-216. Chemical & Physical Properties Molecular Formula C31H42N6O4 Exact Mass 562.326782 PSA 92.29000 Index of Refraction 1.611 InChIKey UXXQOJXBIDBUAC-UHFFFAOYSA-N Storage condition Refrigerator Safety Information Hazard Codes T,N,Xi,F Safety Phrases S23-S37-S45-S61-S36-S26-S16 WGK Germany 2 RTECS AF8575000 Packaging Group II Hazard Class 6.1 HS Code 29154000
Transport InfoProduct Name: Tandutinib (MLN518)
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