![3,4,5-TRIMETHOXY-N-(2-(3-(PIPERAZIN-1-YLMETHYL)IMIDAZO[2,1-B]THIAZOL-6-YL)PHENYL)BENZAMIDE structure, CAS 925432-73-1](/structures/150000/124963_1_925432_73_1.png)
CAS Number925432-73-1
Synonyms3,4,5-Trimethoxy-N-{2-[3-(1-piperazinylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl}benzamide; 3,4,5-trimethoxy-N-{2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl}benzamide; 3,4,5-trimethoxy-N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)benzamide; SRT-1460
Molecular FormulaC26H29O4N5S1
Molecular Weight507.61
Purity96+%
Density1.4±0.1 g/cm3
EINECS0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 925432-73-1 |
| Catalog No. | 2A-0124963 |
| Chinese Name | 3,4,5-三甲氧基-N-(2-(3-(哌嗪-1-基甲基)咪唑并[2,1-B]噻唑-6-基)苯基)苯甲酰胺 |
| Synonyms | 3,4,5-Trimethoxy-N-{2-[3-(1-piperazinylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl}benzamide; 3,4,5-trimethoxy-N-{2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl}benzamide; 3,4,5-trimethoxy-N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)benzamide; SRT-1460 |
| Molecular Formula | C26H29O4N5S1 |
| Molecular Weight | 507.61 |
| Purity | 96+ |
| Density | 1.4±0.1 g/cm3 |
| Storage Condition | 2-8°C, dry, sealed |
| Application | SRT 1460 is a potent Sirtuin-1 (SIRT1) agonist with an EC1.5 value of 2.9 μM. SRT 1460 is highly selective for SIRT1 compared to SIRT2 and SIRT3 (EC1.5>300 μM) and is more potent than resveratrol and |
| EINECS | 0 |
| HTC | 2934100090 |
| UN(IATA) | 0 |
| PubChem ID | 48412535 |
| MDL Number | MFCD19053214 |
| SMILES | COc1cc(C(=O)Nc2ccccc2-c2cn3c(CN4CCNCC4)csc3n2)cc(OC)c1OC |
| InChI | InChI=1S/C26H29N5O4S/c1-33-22-12-17(13-23(34-2)24(22)35-3)25(32)28-20-7-5-4-6-19(20)21-15-31-18(16-36-26(31)29-21)14-30-10-8-27-9-11-30/h4-7,12-13,15-16,27H,8-11,14H2,1-3H3,(H,28,32) |
| InChI Key | SBEWVVLMFLTQFE-UHFFFAOYSA-N |
| Use of | SRT 1460, a potent Sirtuin-1 (SIRT1) activator with an EC1.5 value of 2.9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5 > 300 μM), and is more potent than Resveratrol and the closest sirtuin homologues[1]. Properties Biological Activity Chemical & Physical Properties Safety Info |
| Tax Rebate | 9.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
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