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Spectinomycin HCL structure, CAS 21736-83-4

Spectinomycin HCL

CAS Number21736-83-4

SynonymsSPECTINOMYCIN DIHYDROCHLORIDE

Molecular FormulaC14H26Cl2N2O7

Molecular Weight405.28

Purity98%

Density1.43g/cm3

Boiling Point583.1ºC at 760 mmHg

Melting Point194ºC

Flash Point

Appearancepowder

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9012496 Purity: 98%
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Quality Control of [ 21736-83-4 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number21736-83-4
Catalog No.2A-9012496
Chinese Name盐酸大观霉素
SynonymsSPECTINOMYCIN DIHYDROCHLORIDE
Molecular FormulaC14H26Cl2N2O7
Molecular Weight405.28
Purity98
Density1.43g/cm3
Boiling Point583.1ºC at 760 mmHg
Melting Point194ºC
Appearancepowder
Water SolubilityH2O: 50 mg/mL, clear, faintly yellow
Storage Condition2-8°C
ApplicationSpectinomycin dihydrochloride is a parenteral antibiotic produced from Streptomyces spectacularis.
HTC3004909090
MDL NumberC14H26Cl2N2O7
SMILESCNC1C(O)C(NC)C2OC3(O)C(=O)CC(C)OC3OC2C1O.Cl.Cl
InChIInChI=1S/C14H24N2O7.2ClH/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;;/h5,7-13,15-16,18-20H,4H2,1-3H3;2*1H/t5-,7-,8+,9+,10+,11-,12-,13+,14+;;/m1../s1
InChI KeyFOGDPGQSHLLYIK-XYQGXRRISA-N
MSDSmsds/12496_1_21736_83_4.pdf
Use ofSpectinomycin Dihydrochloride is a new parenteral antibiotic prepared from Streptomyces spectabilis.Target: AntibacterialSpectinomycin is an antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea. Spectinomycin binds to the 30S subunit of the bacterial ribosome and interrupts protein synthesis. One form of resistance has emerged in the 16S ribosomal RNA in Pasteurella multocida [1]. It is given by injection to treat gonorrhea, especially in patients who are allergic to penicillins. A resistance-conferring gene for spectinomycin can also be used as a selection marker in bacteria for molecular cloning purposes. Furthermore, Spectinomycin is used as a selection agent for transformed plant cells that contain the selectable marker gene Spcr [2]. Properties Name spectinomycin dihydrochloride Synonym More Synonyms Spectinomycin dihydrochloride Biological Activity Description Spectinomycin Dihydrochloride is a new parenteral antibiotic prepared from Streptomyces spectabilis.Target: AntibacterialSpectinomycin is an antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea. Spectinomycin binds to the 30S subunit of the bacterial ribosome and interrupts protein synthesis. One form of resistance has emerged in the 16S ribosomal RNA in Pasteurella multocida [1]. It is given by injection to treat gonorrhea, especially in patients who are allergic to penicillins. A resistance-conferring gene for spectinomycin can also be used as a selection marker in bacteria for molecular cloning purposes. Furthermore, Spectinomycin is used as a selection agent for transformed plant cells that contain the selectable marker gene Spcr [2]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Natural Products >> Others Research Areas >> Infection References [1]. Kehrenberg, C. and S. Schwarz, Mutations in 16S rRNA and ribosomal protein S5 associated with high-level spectinomycin resistance in Pasteurella multocida. Antimicrob Agents Chemother, 2007. 51(6): p. 2244-6. [2]. http://www.toku-e.com/Upload/Products/PDS/20120518003891.pdf Chemical & Physical Properties Exact Mass 404.111694 PSA 129.51000 Index of Refraction 1.586 InChIKey FOGDPGQSHLLYIK-XYQGXRRISA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 4H-Pyrano(2,3-b)(1,4)benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis (methylamino)-, dihydrochloride, (2R-(2-alpha,4a-beta,5a-beta,6-beta,7-beta,8- beta,9-alpha,9a-alpha,10a-beta))- CAS REGISTRY NUMBER : 21736-83-4 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : WISWESSER LINE NOTATION : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,382,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,382,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,382,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,382,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,382,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,382,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,382,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,382,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5600 No. of Facilities: 28 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 525 (estimated) No. of Female Employees: 397 (estimated) Safety Information Hazard Codes Xn WGK Germany 2 RTECS WG7400000 HS Code 3004909090 Synthetic Route N,N-bis(benzylo... CAS#:56733-83-6 Spectinomycin d... CAS#:21736-83-4 Literature: Hanessian; Roy Canadian Journal of Chemistry, 1985 , vol. 63, # 1 p. 163 - 172 CAS#:96681-00-4 Spectinomycin d... CAS#:21736-83-4 Literature: Canadian Journal of Chemistry, , vol. 63, # 1 p. 163 - 172 dibenzyl ((1R,2... CAS#:96680-99-8 Spectinomycin d... CAS#:21736-83-4 Literature: Canadian Journal of Chemistry, , vol. 63, # 1 p. 163 - 172 Precursor & DownStream Precursor 2 CAS#:56733-83-6 N,N-bis(benzylo... CAS#:56733-82-5 N,N'-Bis-(carbo... DownStream 1 CAS#:1695-77-8 Spectinomycin
Transport InfoProduct Name: Spectinomycin Hydrochloride
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